Fast Mimicking Diet 6: Implications for Coronary Artery Disease

Fast Mimicking Diet 6: Implications for Coronary Artery Disease

References: Whitehall StudyScienceBMJPublic Health NutrAnnals of Int MedBMJ,

Heart attacks are what we die from in America. Fifty percent of us will meet our maker via heart attack, both men and women. It is the penultimate sign of aging, and the last sign for 30% of those who present with sudden death as their first indication of heart disease. We have made huge strides in reducing morbidity and mortality from heart disease in the last 50 years. Longo’s estimate is that we would have roughly 3-4 times the effectiveness on reducing mortality if we focused on enhancing resilience and longevity with the Fast Mimicking genetic program.
Ok, I’m in. Give me the details as they exist now. Let’s start with historical perspective. We know from the Whitehall Study in England that heart disease declines in frequency until your blood glucose is 86. We define diabetes as 124. Hmm. That’s obviously an arbitrary definition made by a committee. The implication is that the lower your glucose is, the less heart disease you will have.

All right. Second concept. The Madison, Wisconsin Rhesus monkey study in which two groups of monkeys were compared with normal diet versus 30% reduction showed that 42% of the normal control diet developed diabetes versus none of the calorie restricted. And cardiovascular disease was reduced 50% in the calorie restricted diet.

What we don’t have is large studies looking specifically at the “Longevity Diet” for coronary artery disease. Instead, we have studies that are close, and probably close enough to be legitimate comparisons. For example, Sofi and Cesari show that adherence to a “Mediterranean Diet” has dramatic reductions in heart disease, Parkinsons, cancer, diabetes. And the closer you adhere to a “Mediterranean Diet” the less heart disease you have. The overlap of “Mediterranean” and Longevity diets is significant. Both are founded on high olive oil, legumes and unrefined cereals, low meat, eggs and cheese, What the Longevity adds is evidence based additions like Time Restricted Feeding with an 11-12 hour feeding window and a 12-13 hour fasting daily, lower animal protein intentionally and lower fruit use.

And the opposite argument is valuable too. If you eat more animal protein and less carbs, as in one arm of the Harvard Professional Health study, you show that mortality doubled from all causes and increased 40% with cardiovascular disease. If low carb but vegetable based, increased CV disease disappeared. Another study from Swedenof 43,396 women showed a 5% increase in cardiovascular disease for each 5 gram increase in protein intake concomitant with a 20 gram decrease of carbs.

Finally, we have Dean Ornish’s and Caldwell Esselstyn’s diets in which folks are kept on extremely low fat, vegan diets. Their patients also showed regression of coronary artery disease. Their limitation is that compliance requires intense discipline, and most folks can’t maintain it.

My conclusion: we have something real here. The challenge is to make it palatable and sustainable. Well, nuts and olive oils are tasty. Fish is pretty good too. Including these fits in the Mediterranean construct, but also matches the behavior of long lived populations like the Okinawans, Greeks of Ikaria, Italians of Calabria, Seventh Day Adventists of California.

WWW.What will work for me. Heart disease is the elephant in the room. It’s what we Americans get. And we get it in proportion to our obesity, and our blood sugar level. I’ve eaten low carb, high protein for two years and ended up with an A1c of 5.9. Low carb is a fine way to lose weight, in the short term. The longer term is now revealed with this new idea: episodic 5 day fasts combined with a low animal protein, high olive oil, high vegetable diet. I’ve switched my breakfast from two eggs to one egg with spinach made in coconut oil.

 

Pop Quiz

 

  1. Increasing animal protein by 5% will increase your risk of heart disease by?             Answer: 5%
  2. Animal protein turns on what “aging” pathway?                                               Answer: The mTOR pathway
  3. At what level of glucose does heart disease no longer occur?                        Answer: 86 (And we define diabetes as 124)
  4. Name key components of the Fast Mimicking Diet.                                        Answer: Daily 12 hour fasting, monthly-quarterly 5 day fasting, low animal protein, high vegetable, low sugar, low refined grains, no trans fat,
  5. The best research studies we have that show the benefit of the Longevity diet looks at what current eating pattern?                                                                                        Answer: The Mediterranean Diet, but we will give you credit for saying Ornish’s or Esselstyn’s too

 

 

Fast Mimicking Diet 5: Cancer and the Magic Shield

Fast Mimicking Diet 5: Cancer and the Magic Shield

References: CellBMC CancerCancer CellPLOS Biology,

Last week we learned about reversing diabetes. This might be the Holy Grail of modern medicine. The prevention and treatment of cancer might be just as important. Cancer frequency increases with age, essentially equating aging with more disease. How to prevent it?
The first key concept is to understand how cancer comes about. It takes a key mutation, or probably several mutations or changes in the DNA sequence of a cell, for the cancer cell to develop “oncogenes”, cancer favoring genes. Cancer cells stop obeying orders, which in fact makes them weaker and more vulnerable to damage from external toxins. This is why Vitamin C, ozone, and many chemotherapy drugs have a deterring effect. It’s as though cancer cells are race cars with the accelerator stuck to the floor: they can’t slow down.

Longo recognized that key characteristic of cancer cells, and the essential response of healthy yeast/worms/mice to the fast mimicking diet. When you deprive healthy cells of key nutrients for a fixed period of time, they recognize that they are in trouble. The “get the memo” and respond by hunkering down. Longo called it the “magic shield”. Cancer cells can’t do that. The cancer cell tries to keep growing, even with no nutrients around.

In an experiment with mice, one of Longo’s graduate students gave mice chemotherapy and compared a group with normal daily diet versus some fed no food for two days prior to the chemo. The differences were striking. The fasting mice were dandy, the normally fed mice all got sick. In a week or two, 65% of the regular diet mice were dead. The same dramatic effects were found when micewith lung cancer were given chemo with or without fast mimicking: the fasting mice had 60-70% remission rates compared to much lower in the normally fed mice.
It appears there are two key dynamics going on with this cancer effect: the first is that the fasting weakens the cancer cells, making them more vulnerable. The second is that it renews and “revs” up the immune system, making it more aggressive against the cancer cells..

And the effects go beyond just making the immune system stronger. The use of potent steroids is a part of many chemo regimens with mixed blessings as the resulting elevation of glucose adds to toxicity. The FMD reduces glucosedramatically, suggesting that the use of steroids should be reconsidered.

Where are we with randomized clinical trials in cancer? Considering that there are several hundred types of cancer scattered all over, it takes a while to conduct studies on any one cancer with this strategy, so there are very few studies completed. The three or four that Longo refers to in his book make the strong argument for safety of the strategy, reduction of side effects, increased ability to complete chemo regimens. With that in hand, Longo suggest the following guidelines in his book. 1. If the oncologist agrees, the patient may fast or do the FMD for three days before chemo and 1-2 days after standard chemo drugs. 2. If fasting, make sure you don’t resume regular eating immediately following the chemo as the rebounding growth of liver cells at a time of lingering blood levels of chemo lead to liver toxicity. Weather it out with fasting at least 24 if not 48 hours after the chemo. And start slowly on vegan food, with lots of olive oil: rice, bread, pasta, vegetables and soups. Finally, try to return to normal body weight between cycles. If on any diabetes drug, please, please consult a knowledgeable physician first.

WWW. What will work for me. And just what do you want to do if you have high risk for cancer? Start by reading Longo’s book. If I had the BRCA gene, I would be doing this diet for the rest of my life. I do have diabetes genes in my genetic code, so I probably will be doing this the rest of my life, just like all of us should be. Your blood tests will tell you how often you should be doing it. In the meantime, I’ve now seen three people with dramatic success in just a few months with their diabetes getting better. Want to join that list?

Pop Quiz

 

  1. The Fast Mimicking Diet is called what by Longo?                                                Answer: The Magic Shield
  2. Cancer cells disobey orders and can’t do what?                                                   Answer: Take their foot off the accelerator and stop growing when there are no nutrients around.
  3. What happens to your immune system against cancer after you FMD?            Answer: Rev Rev.
  4. What’s the likelihood of your doing better if you do FMD while getting chemo? Answer: Fewer side effects and likelihood to get more chemo in you.
  5. Do we want you to lose weight via the FMD when you have cancer?                 Answer: NO! In between cycles we want you to gain it back.

 

Fast Mimicking Diet 4: Reversing Diabetes

Fast Mimicking Diet 4, Reversing Diabetes

References: Whitehall StudyCirculationAgingDiabetes CareCell,

This is a big deal. If you read no email this year but this one, you will be well served. The reversal of diabetes is so important, it is a game changer for all of medicine. Why? Two reasons.

The first is that it is so destructive, effecitively being the cornerstone for all our diseases of modern society. We have defined diabetes by committee and decided that it really wasn’t a disease until you got to a blood level of 124 or so, measured twice, or a Hemoglobin A1c of 6.2 or 6.4 (Remember: the A1c is the percent of hemoglobin molecules with a glucose stuck on them. Red cells live 100 days, about, which makes the A1c a nice surrogate marker for your average glucose over the last 100 days.. But that is looking at a disease you might think about treating. What would happen if you decided to consider what blood sugar results in optimal function? I would refer you to the Whitehall Study from England, It showed that for every point of glucose above 86, you have a 5% increased risk of heart disease. And there is wide acknowledgement now that we need to lower blood sugar, which modern medicine does by treating with drugs. That means an optimal blood sugar should be 86. Bredesen shows abundant evidence that a HgbA1c of 5.5 is what you want if you are anxious about Alzheimer’s.

The second is that everyone has it. There are all sorts of papers saying how many millions of people have it, but that is the DISEASE. If you want optimal function, the picture is much gloomier. The simplest explanation of how your body progresses to diabetes is as follows: your fat cells become insulin resistant in relationship to their size. As you get fatter, your fat cells get bigger. You don’t make ore. And your insulin receptors get further apart, So you become insulin resistant. You raise your insulin to keep that blood sugar in control, which you can only so for so long. After a while, you run out of the ability to keep raising your insulin level. It’s as though you were only given so much insulin in a lifetime. As long as you were only burning a tiny amount a day, you can live a very long time. But it has become pretty apparant that once we get overweight, we are burning up our insulin supply faster than we can maintain for a lifetime of 100 years. And that is what we see today in modern medicine. As we age, being a bit plump gradually turns into our blood sugar slowing rising, and your being put on one pill after another until you get to age 55 or so, and then you flunk out and get put on insulin. Your islets in your pancreas look shaggy with fewer healthier insulin producing cells. And then your kidneys fail and you get on dialysis, and then you flunk and get Alzheimer’s. Till now, the key to reversing diabetes has all been about losing weight, making fat cells smaller and getting the residual ability you have to make insulin in line with your reserve of insulin producing capacity. Imagine having an insulin level of 35 when you weight 190, but a level of 2 when you weight 132. That’s what we see clinically happening.

Here is where the Fast Mimicking Diet (FMD) comes in. What would you think if I told you that the FMD turns on the genes that literally wipe out old, dead, decaying tissue and starts rejuvenation of new insulin producing cells? Yes, produces new insulin cells. We have never seen anything quite like this before. This is like the holy grail of medicine, and it’s right there in front of our faces. The FMD turns on genes that support resiliency, getting rid of old garbage that’s in the way and turning on the growth of new stem cells. This is dieting for your genes sake. And all we are asking of you is 5 days a month until you have got yourself fixed.

WWW.What will work for me. I’ve been getting older and I have a family history of diabetes. To my alarm, this year my A1c ticked up from it’s usual 5.2-5.4. I’ve already done one cycle. I’m starting cycle number two. I just came back from a trip to see old friends I grew up with in India. I’m going to send them copies of Longo’s book. My advice to you is to not trust me, or your own doctor on this topic. Trust your own lab results. Watch your own response. The data is there. This diet will eventually become the “human diet”. We will all be on a variation of it. The good news, if you don’t have any risk factors, is that you only need to do it twice to three times a year, provided you exercise properly.

Pop Quiz

 

  1. Diabetes starts at a Hemoglobin A1c of 6.2. T or F                                         Answer: true, if you call it as the disease and use current medicine’s standards. Optimal is a whole different story. If you have worries about heart disease, Alzheimer’s. autoimmune disease.. or just want to age gracefully into your 90s, you want an optimal A1c: below 5.5
  2. You can lower your A1c by losing weight. How does that work?                    Answer: your fat cells get smaller and the residual insulin you have left become in line with the amount you need to control those fat cells.
  3. If I’m getting a little older and a little heftier, what is happening to my insulin producing cells in the islets in my pancreas?                                                                                 Answer: They are getting fewer and making less insulin.
  4. How many days do I have to do this diet thing?                                                Answer: 5. Four, as best we know, isn’t sufficient.
  5. What is an optimal blood sugar?                                                                         Answer: Your family doctor will tell you under 100 or so but won’t call you diabetic until you are 126, or if they are just checking your urine, you will be normal when you have a sugar below 180 because your kidneys can reabsorb anything below 180. (I kid you not, I talked to a person this week whose doctor was still checking urine for diabetes.)

 

Fast Mimicking Diet 3: The Fasting Part

Fast Mimicking Diet 3 The Fast Mimicking

References: Longo: The Longevity Diet, [Science], Science DirectCellCell Metabolism,

I like to eat. I get hungry. What is it about fasting that makes me do better? Let’s review. Valter Longo found that there were two processes in yeast (very primitive organism) and mice (sophisticated mammalian organism) that respond in the same way. RAS and TOR. Those are the two pathways that appear to accelerate aging. Sugar turns on RAS-PKA and extra protein turns on TOR-6SK Growth Hormone Pathway. If you can down regulate the RAS pathway, you increase the rate of clearing out old, dead, malfunctioning tissues and organelles. That’s called autophagy. TOR is an internal monitor of nutrient density and controller of cell growth. Can’t grow if you don’t have enough food. Dial TOR down and cells stop dividing and go into hunker down mode. Alter those two pathways and presto, chango, you have gotten to the root cause of aging in humans. That discovery, that these two pathways are fundamental to all life on this planet, starting with yeast and moving all the way up to humans, is Longo’s key contribution to modern understanding of aging.
Fasting turns both those pathways in the right direction. It takes about 24 hours to use up the glucose in your liver, stored as glycogen. The human body then switches to burning fat from stores in fat cells. The brain and body utilize ketone bodies in a process termed ketolysis, in which acetoacetic acid and 3-β-hydroxybutyrate are converted into acetoacetyl-CoA and then acetyl-CoA. In yeast, glucose, acetic acid and ethanol, but not glycerol which is also generated during fasting from the breakdown of fats, accelerate aging. Not glycerol. Did you get that? There is one carbon source that doesn’t turn on the nutrient recognition pathway. Glycerol is the 3 carbon fragment that holds fats together in tri-“glycerides”.

Fasting for 3 or more days in humans causes a 30% decrease in circulating insulin and glucose, as well as a reduced level of insulin-like growth factor 1 (IGF-1), the major growth factor in mammals, which together with insulin is associated with accelerated aging and cancer. Fasting for five days results in a 60% decrease in IGF-1and a 5-fold or higher increase in one of the main IGF-1-inhibiting proteins: IGFBP1. This effect on IGF-1is mostly due to protein restriction, and particularly to the restriction of essential amino acids, but is also supported by calorie restriction since the decrease in insulin levels during fasting promotes reduction in IGF-1. In humans, chronic fasting does not lead to a decrease in IGF-1 unless combined with protein restriction.
Did you get all that? It’s the protein restriction that matters. Five days appears to be the time period in which maximum reduction of cancer growth factors and insulin occurs. You can trick the system with some glycerol which doesn’t register as a sensed nutrient. And we have some markers of metabolism to show your success. 5 days. Reduced protein, animal in particular. Cut the calories down to low enough to turn on and maintain ketogenesis. Sounds like about 800 a day will work. The goal isn’t to lose weight but to turn on anti-aging genes.

WWW. What will work for me. Well, I’ve finished one cycle for myself and lost 6 pounds while doing it and another two pounds over the subsequent three weeks. Not bad. I’m going to do two more cycles and then repeat my own lab tests. Glycerol makes an interesting little sport drink. It’s slightly sweet and with a bit of flavor added from a tea, it’s not so bad. I’ve bought some hibiscus tea.

Pop Quiz

 

  1. What nutrient can you consume that is slightly sweet and doesn’t trigger calorie sensing? Answer: Glycerol
  2. What amino acid turns on aging, and absence turns off aging? Answer: leucine in particular.
  3. Five day fasting results in a 60% decrease in what? Answer: IGF-1 or our Growth Hormone surrogate marker.
  4. Along with that, you get up to a 5 fold INCREASE in what IGF-1 inhibitor? Answer: IGFBP1.
  5. What lab tests might you want to know if you were getting success in your fasting methods? Answer: Glucose, insulin, IGF-1 and IGFBP-1

 

Fast Mimicking Diet 2: The Human Method Simplified

Fast Mimicking Diet 2 The Human Method

References: Longo: The Longevity Diet, ScienceGut,

Last week we heard about yeast being used to explore what genes are needed to make the right environment for longevity. Valter Longo’s hypotheses was that those same genes exist in mammals, humans included. If he could make the same changes in longevity by diet and its effect on genes in mice that he made in yeast, he would have a huge scientific win. He started looking at mice and their genetic code. Mice live about two years and start getting cancer around a year and a half. That makes a useful model.
What did he find? The exact same thing. Two key ideas. Extra sugar activate the PKA gene. That causes trouble. Mice with lower PKA activity, live longer. That simple. And extra protein activates the growth hormone receptor and TOR-6SK and increases the level of insulin and insulin like growth factor. Certain amino acids appear to be more potent at activating the TOR-6SK complex, like leucine. which then accelerates aging. That’s it. The foundation of aging down to two simple key processes. Too much sugar, and too much protein. That duo is the foundation of what Longo called his “basic juvenology research”, one of his Five Pillars of Proof.
The story is all about the nuance of glucose and protein.

Our body runs on glucose. It is our preferred food for our brain, if present. The story is all about how it is delivered and what happens to our bodies if we get too much, too fast. When you get low glycemic carbs from vegetables, your blood sugar rises very slowly and you hardly get an insulin response. (For example, it takes 19 cups of asparagus to make 50 grams of glucose). If you have a diet of broccoli, spinach and green beans, you hardly get any insulin spike at all. A substantial portion of those vegetables make it to your colon where the biome in your colon changes those coarse fiber rich foods to short chain fatty acids, just like in gorillas (See this column from 2 weeks ago). Just like with gorillas, a high fiber diet actually results in substantial increase in fatty acids, or fat. Adhering to a Mediterranean Diet appears to make this possible, all due to the activity of the biome in your gut.
A high protein diet changes your gut biome and increases many markers of cardiovascular disease,TMAO (trimethylamine oxide). So we have seen these changes from other lines of research as well.

We are even beginning to understand the incredible complexity of our gut biome. Our colon is there to take high fiber foods and digest them for us, releasing short chain fatty acids, turning low glycemic vegetables into short chain fatty acids. Bacteroidetes are more abundant in the stool samples of those eating a mostly plant based diet, while Firmicutes were more abundant in those who eat a more animal products diet. From those major families, the specific bacteria Prevotella and Lachnospira were more common in vegetarians and vegans while Streptococcus is more common among the omnivores with higher meat intake.

Can we take this to humans with specific guidelines? Well yes. This is what Longo has come up with. Protein should be about 0.31-0.36 grams per pound per day, of which about 40 grams for women weighing 130 and 60 grams for men weighing 200. Once you hit age 65, you likely need a little more protein, but not that much. Just a little.

Your diet should be rich in healthy fats like olive oil, fish and coconut oil, walnuts and almonds. These fats essentially do the same process of helping you get more calories from fat, like the gorilla. Trans fats and saturated fats are to be avoided. And there should be plenty of Healthy Carbs – the type that make it to your colon and turn into fat. They generally have a glycemic index under 20, or 45 max which would include beans (if you aren’t lectin sensitive). The carbs that get digested in your small bowel and make sugar spikes look like ground flours of any kind, sugar in particular, high fructose corn syrup in double particular, fruit juices or too much modern fruit (modern apples are nowhere near the original Himalayan apple – ditto for pears, bananas, on and on that we have altered in the last 100 years to be much richer in sugar). Most grains are just too rich in carbs to be too good for you, unless you have changed them to be resistant, usually by cooking and then cooling. Same with potatoes. The original potato from Peru was a fine food with a GI of 40. Now it’s a glycemic index of 80-95, unless you boil it and cool it making it resistant. (Is this enough to confuse you a little?)
Finally, cut your meals down to 2 and a snack. Try to fit all your food into 11-12 hours of eating and not for 3 hours before bedtime. Breakfast is NOT the meal to skip as there is plenty of evidence that that habit correlates with many illnesses.

Ok? Next week, we will discuss how to FAST and do it right so that you kick start your genes into being supercharged. It’s cool, and it works.
WWW. What will work for me. This is evidence based and I get it. I’m so fascinated that I drew my own lab tests and started doing it full bore, as much as can be done living in a modern 8-5 work world. It’s the fasting part that has my attention. I’ve completed my first 5 day session and intend to do it again. It wasn’t so hard. More next week.

Pop Quiz

 

  1. Animal protein appears to shorten longevity? T or F                           Answer: True
  2. We need animal protein to support our healthy brain? T or F          Answer: Again true. Conundrum? Yup. We get B12 only from animal sources. But nature doesn’t care much about you once you have made your babies and passed on your genes.
  3. A high carb diet is bad for you. T or F                                                    Answer: All in the details. High in low glycemic green vegetables, it’s very good for you and is actually a high fat diet.
  4. The über enemy of nutrition is?                                                           Answer: Sugar, fructose in particular when it gets above the 6% found in fruit.
  5. How much protein can I have a day?                                                   Answer: 0.31-0.16 grams per pound when under 65 A little more after. But not much.

 

Fast Mimicking Diet 1: Starting With Yeast

Fast Mimicking Diet 1: Starting with Yeast

References: Fabrizio Science 2001Science Translational MedJBCPNASGenetics,

You’ve heard of fasting and how it encourages the body to live longer. Well, sort of. The problem is, you like to eat. And eating is critical to keeping you alive. Let’s turn it around a little and come at it from a different way. Can we make the argument that we can identify the process by which changing patterns of food, including low calorie periods of time, turn on “good genes” and what are those “good genes”?
Turns out no one had looked at aging from that point of view prior to Valter Longo. He set out on his career with the premise that the way to explore healthy aging should be to identify and encourage the genetic processes by which we can build resiliency and healthy aging. He started with yeast because they live just a few days and all 6000 of their genes are known. It’s easy to make mutations and delete a gene and see what happens. Here is what he found.
In yeast, if you take away all nutrients from them except water, they live twice as long. Hmmm. If you add back nutrients, one at a time, the only one that accelerates aging… the ONLY one, is sugar. It activates two genes called RAS and PKA and inactivates enzymes and factors tha protect against oxidation. Boom, there he was. He found a key pathway in the gene signaling pathway that caused aging. And when he came out with it, as the basis of his PhD thesis, it was so new and so far ahead, no one would believe how a lowly graduate student could come up with such a significant finding, and he was ignored and avoided. He teamed up with folks looking at more complicated organisms, worms, and found much the same but to jump from yeast to humans was too big a paradigm shift for folks to believe, and thereby publish his data. It took 6 years for him to get published in Science, and another eight years to get a study on humans showing how down regulating the human growth hormone gene helped humans live longer Sci Trans Med would be published.
He discovered that dwarf yeast and mice lived 2-6 times longer, so he sought out populations of dwarf humans in Ecuador, the Laron Syndrome folks, who are tiny dwarfs that smoke, drink, eat fried food and don’t get any diseases of aging like diabetes and heart disease. Studying that population found that their defect in their growth hormone gene forced their body to go into constant regeneration mode. Studies of their brains showed that their brains were much younger in function than the rest of their bodies. That was the key. Regeneration mode. What on earth was going on? He suddenly found his ideas being accepted. Even the Pope wanted in, and he took some of his Laron buddies off to Rome to review his finding.

Starting with that research, Longo noted that aging is the risk factor that is common to all disease. The older you get, the higher your chances of getting……..you name it, cancer, diabetes, heart disease, Alzheimer’s. Hence, start with that problem. Reduce the aging pathway and those diseases will take care of themselves. That’s why the Laron stayed “healthy”, despite all their bad habits. So, can we duplicate that by changing the way we eat? Yup.
What is the simplified version that we can understand? Easy. There are two pathways that appear to accelerate aging. The Sugar pathwy turns on RAS-PKA and extra protein turns on TOR-6SK Growth Hormone Pathway. If you can down regulate the RAS-PKA pathway, you get autophagy – you gobble up old dead stuff and get rid of it. TOR-6SK is a critical monitor of nutrient density and controller of cell growth. Dial TOR down and cells stop dividing and go into hunker down mode. Alter those two pathways and presto, change, you have gotten to the root cause of aging in humans. That discovery, that these two pathways are fundamental to all life on this planet, starting with yeast and moving all the way up to humans, is Longo’s key contribution to modern understanding of aging.

How can you alter those two? Next week.

www.What will work for me. I’m enthralled with the beauty of creation. From yeast up to humans, we can follow the same biological processes down at the cellular level, and then follow them up through all biology. The Laron People have a terrible mutation in that they end up being only 3-4 feet tall, and then live to 90 with no diseases. And all of this is connected to how we eat. Next week.

Pop Quiz

 

  1. If you feed yeast one food, they die much faster. What is it?                    Answer: sugar
  2. The one process that makes years live twice as long is?                            Answer: feed them nothing but water.
  3. Who are those people in Ecuador that live to be 90 with no diseases, despite eating fried food and smoking like chimneys?                                                                  Answer: The Laron who have a defect in growth home production – and end up 4 feet tall.
  4. What two pathways do we share with yeast, and mice, and worms, and snakes, and monkeys and everything in between?                                                            Answer: TOR and RAS
  5. What do TOR and RAS do (BONUS POINTS)?                                                 Answer: RAS measures nutrients and turns of housecleaning when there aren’t any. TOR measures nutrient density and turns on “hunker-down” mode when there is little.

Lectin Lesson 5: Resistant Starch is a High Fat Diet – Ask the Gorillas!


References: Steven Gundry’s Plant Paradox, Journal NutritionJ. Internal MedNature,

Once upon a time our diet was very similar to gorillas. Say some 10 million years ago, and prior. We ate leaves, in Africa. Only 8 million years ago did we diverge from chimpanzees and only 2 million years ago did our brains start getting bigger in response to eating meat. We had learned to run long distance, which made us the most successful hunter in Africa. But our guts were still used to eating leaves, and designed to do so.

What happens on eating leaves? Leaves are very dense, high fiber foods. Gorillas eat about 16 pounds a day, in today’s gorilla. The gorilla can’t digest those leaves, but their gut biome can. The bacteria in their gut break down the leaves and convert the cell walls of those plants into tiny, short chain fatty acids. Net effect, the gorilla’s diet becomes 70% fat, ideal food for brain and nerve cells. What looks like a high fiber, low fat diet turns into a high fat diet when the gut biome is properly nourished and contributes like it was designed to.
Now, let’s make a pivot and see if we can find anyone on this planet who eats a high fiber, high fat diet. We end up with a unique society in remote New Guinea called the Kitavans. A Swedish Researcher, Lindeberg, did a studyon the Kitavans who eat virtually no western food, 70% carb, and 20% fat and have absolutely no obesity, no heart disease, no diabetes and live into their 90s, while smoking. Imagine that!
How do they do that? They eat a ton of resistant starches in the form of taro, coconut, fruit and fish. We find much the same from Tokolau, another remote Polynesian Island with no western food: just mostly coconuts and fish.

The key is that idea of resistant starches. These are “carbs” that don’t act like most carbs. They don’t get digested in the small bowel. In the process of cooking their molecular shape is changed.  They are passed on through to the lower gut where they are ideal foods for your gut bacteria. Your colonic biome goes nuts with happiness and digests them down into short chain fatty acids, turning what looks like carbs into fat. This is the same hat trickthe gorilla does in their gut. Not only that, with all that food, the bacteria make a thick coat of mucus in your gut and you make a much more effective barrier to absorbing those dangerous lectins and LPSs fats that turn on inflammation – so you make a better natural barrier. Resistant starches reverse the damage of red meat. Now, many resistant starch foods are high lectin foods: boiled and cooled potatoes, rice – cooked and cooled, beans and oats. Gundry acknowledges this and advises you eat green bananas. Not ripe ones where the carbs are sweet and absorbed, but green where they are still resistant.

Turn on the lens of resistant starches and suddenly long lived societies around the world come into focus. They all have the same features in common. Their diets show high fiber diets of resistant starches, which their colonic biome turns into short chain fatty acids. Their brains get high fat intake. On Okinawa, the fiber is in the form of yams. Sardinians and Cretans eat high fat in the form of olive oil. Seventh Day Adventists are vegetarian, but eat about 60% fat from olives and peanuts. The Mediterranean diet goes straight for the olive oil, making an approximate high fat diet. We know your brain does better eating fat. It has to be the right fat. And having your colon make it for you appears to be the right concept. Thank you, gorillas.

WWW.What will work for me. Gundry is turning our dietary concepts on its head. But data is data. The Kitavans make for a unique example. Ditto from Tokolau Island(70% of diet from coconut). There is rice being developed on Okinawa that is particularly resistant. I’m curious if I can find it. I’m not taking up smoking. But will I eat a bit of rice now? Yes, if it has been cooked and then cooled down. Raw banana, well, I’ll try one.

 

Pop Quiz

  1. Gorillas eat a high fat diet? T or F                                                    Answer: False, they eat a resistant starch diet that is turned into high fat in their gut
  2. We can find examples of high fat diets all around the world. Name some.
    Answer: Sardinians, Tokolau, Crete, Loma Linda Adventists.
  3. Resistant Starches do what?                                                            Answer: Get through your small bowel undigested and give ideal food to your colonic biome where they make small fatty acids, ideal brain food.
  4. Folks eating high carb diets are in trouble for diabetes? T or F        Answer: Stupid question because there is no nuance. Eat a pizza and the high glycemic wheat crust and fatty cheese and meat will instantly turn on weight gain. Eat a high carb diet of taro root and raw bananas, and you get no weight gain.
  5. If you smoke, you can get away with it? T or F                                     Answer: True, if you move to Kitava and eat raw bananas and taro root. Otherwise you just die sooner.

 

 

 

Lectin Lesson 4: What Elephants Having Heart Attacks Teaches Us About Cancer

References: Steven Gundry’s The Plant Paradox, CirculationScience Direct,Front Oncol., Glycobiology,

Ok, caught your attention? Elephants having heart attacks? Yes, it’s true. Now, when elephants live in their natural habitat that has sufficient tree and brush forage, they never get a heart attack. In the last couple of hundred years they have lost habitat and been driven to eating grasses. Elephants don’t eat grass when they have natural leaf habitat – they eat leaves. When they eat grass they develop coronary disease, just like us. Why does that happen?
We share an odd and uncommon sugar with elephants. It is called Neu5ac. I’ll call it N-A. It’s a member of the sialic acid family of sugars. We share it with shellfish, chickens and elephants. When we diverged from chimps 8 million years ago, we started making Neu5ac (N-A). Chimps make Neu5gc (N-G). As do every other mammal including the ones we eat like cows, goats, sheep, pigs. This sugar, N-A) is like a signal in our gut cells and our arteries. And grain based lectins bind avidly to it. WGA, the lectin in the wheat germ, binds avidly to it. Avidly. But grain lectins don’t bind to N-G.
Here’s where the link happens. When we eat red meat containing Neu5gc – N-G, your immune system recognizes it as foreign and makes antibodies to it. Those antibodies then turn around and attack your own Neu5ac (N-A) receptors. You get antibodies on your blood vessel walls. You call in white cells. Coronary artery disease is off and running. When elephants eat grasses, they get the same cross reactivity. Something about having grass (wheat) based lectins that attach to Neu5ac and eating the Neu5gc form of the sugars makes for that autoimmune attack.
Now, swing over to cancer. Human cancers have a lot of the Neu5gc protein in them. They put it on their surface as a means of hiding from our immune system. Wait a minute! We don’t make it. Human cells cannot make Neu5gc. Right, we don’t. Then how does the cancer get it? From our eating it in red meat. That may be the link between our eating excessive red meat, and having more cancer. The more red meat you eat, the more N-G you get to supply cancer cells with camouflage. Did you notice that chicken and shell fish don’t have N-G. They have N-A, just like humans and elephants. When you eat chicken and shell fish, you have less risk of heart disease and cancer.

The mechanism that is driving both of these phenomenon is the presence of these sialic acid sugars called Neu5ac versus Neu5gc. Their subtle name difference is the whole universe of immune recognition. That simple little alteration is all it takes for your immune system to go the wrong direction and start a process that leads to the slippery slope of coronary artery disease, or cancer.

WWW. What will work for me. This is a smoking gun. It tells us the clear mechanism by which this elegant, delicate signaling system shifts our immune reaction against either ourselves or against our own immune vessels. Or cancer. It’s simple. We get B12 from red meat. We have to have it. A tiny bit. I mean tiny bit. Seems like we need to start thinking about how we can change the balance of calories. If ketogenic eating is important for our brains, then it has to be with healthy fats, not meat. And it all comes down to those magnificent gentle animals, elephants.

Pop Quiz

 

  1. Elephants were designed to eat grasses? T or F                                               Answer: False Leaves
  2. When elephants eat grasses they develop what illness in common with humans?           Answer: Coronary artery disease
  3. The key link in the immune response is a lectin binding sugar called?                             Answer: Neu5ac – a member of the sialic acid family of sugars
  4. The principal damaging lectin in wheat, WGA binds to which of the two sialic acids – Neu5gc or Neu5ac?                                                                                                                                Answer: N-A not N-G
  5. Human cancer cells get their camouflage from?                                        Answer:     Red meat Neu5ga.

 

 

Lectin Lesson #3: How Lectins Make you Fat

Reference: Gundry’s The Plant ParadoxAm Jr Physiology,

Did you know that humans lost height and brain case size in the 1000 year transition from hunter gatherer to wheat grower. Gundry quotes this in his book as what has been discovered at archeological sites from those time periods. Civilization had its costs? All so that we could have kings and cities and armies and compete with your neighbors more effectively. Hmm. And we started domesticating pigs and cows, sheep and goats….so we didn’t have to go hunting. Here is Grundry’s conjecture. Wheat and lentils are amazing grains. When you eat them, you gain weight faster and more efficiently to that you can make it through winter more efficiently. Civilization liked wheat, because by putting calories on into storage, those who ate it lasted longer.
Now, extend that to today and see if it’s any different. What do we feed cows before we slaughter them for market – corn and beans? Wild pigs are lean animals. Domesticated pigs have lots of fat (we call if bacon) when fed corn and beans. Those foods make animals fat too. So Gundry’s hypothesis is that humans didn’t choose wheat and lentils to grow because they could be stored, but because you put weight on the most effectively with them. That’s his Plant Paradox. The very plants (wheat and beans) that allowed our ancestors to develop civilization and store calories for the winter were the same plants that hastened our demise from metabolic diseases. Now, that was hidden for the last 9,000 years because we died of measles and tuberculosis and cholera by age 30 anyways, and didn’t see the degenerative effect of inflammation caused by these grains. Grains became the means to civilization not because they could be stored, but because they were the most efficient means to put on weight and make it through winter. They promote more calories into fat deposit than any other food. And then, isn’t it curious that milk from black cows, so called A-1 milk, has lectin qualities to it too in its BMC-7 fragment, and promotes weight gain.
Ok, I get the historical conjecture but is there a coherent biological explanation for how this works? Yes, indeed. It goes as follows. Two key processes are going on.

First, the disruptive effect of the lectin in wheat called WGA. Wheat germ agglutinin. It looks a lot like insulin. Acts like insulin. That’s what lectins are, proteins that mimic mammalian proteins and cause damage by disruption. WGA mimics insulin, badly. Insulin attaches to a cell for a tiny amount of time, then lets go. WGA doesn’t let go. On a fat cell, the message is to take up glucose, forever and ever. That fat cell gets fatter. On a muscle cell, however, the message is to block insulin effect so muscle are starved. Again, WGA doesn’t let go so the real hormone that should be on the receptor can’t dock on its receptor and tell the muscle cell to take up glucose and run with it. Same effect on nerve cells: WGA clamps on and doesn’t let go. Nerve cells are starving. But they send out the message to the organism: “Eat more.”
Even more disturbing isrecent evidence has emerged that lectins can climb up the vagus nerve from the gut to the brain, damaging the substantia nigra, the seat of Parkinson’s disease. Indeed, cut the vagus nerve and the risk of PD drops 40%.
The final argument to support Gundry’s hypothesis might be called the Common Soil Hypothesis – that the mechanisms of metabolism and inflammation are curiously linked. You got fat because your body is at war with itself. And it goes as follows. The lectins set off your “Tiny Little Radars”, your Toll Like Proteins, that reside in your blood vessels and fat cells. They set off cytokines (your body’s fire alarms) calling for white cells to respond to clean up the invading bacteria. Except there are no bacteria. It’s just lectins. But the white cells show up. And your body shifts into war mode. Energy goes to the troops, the white cells. The stay-at-home folks, (Gundry calls them civilians but you think of them as muscle and brain cells) go on war rations and get less. Hence, you become insulin and leptin resistant not because you are overweight, but because your body is inflamed from all the fake lectin signals setting off fire alarms about invading bacteria. Your body is at war, thinking you have been invaded by bacteria, and you are all pumped up and ready to defend. Except that there is nothing to defect. The home folks starve. Fat cells get bigger.

Get it? Stop the war, send the troops home. Weight loss follows automatically. Stop eating lectins. That includes A-1 milk and cheese, nightshade plants, wheat and beans and most of all, genetically modified foods with their genetically inserted extra lectins.

www.What will work for me. This is a paradigm shift type of thinking, but it makes perfect sense. I get it. I just have to figure out how to implement it. And wheat is lurking behind every food in America. And every meat product was raised on lectin foods: corn and soybeans so the lectins in those foods are still there for me to absorb. I have to live with this a while. But I can shift a little. Less beans, less wheat. One step at a time.

Pop Quiz

  1. You are leptin resistant and fat because you eat like a pig? T or F                      Answer: That’s backwards, unless you take eating like a pig to mean you are eating corn and beans, lectin foods. The proper answer is that leptin resistance and fatness comes from the natural shifts your body makes to counter the fake messages caused by eating lectin containing foods. You eat secondarily because your brain cells and muscles are starving, ironically.
  2. Lectins set off inflammation because they activate TLRs? What are TLRs?
    Answer: Toll Like Receptors or “Tiny Little Radars” in Gundry’s clever nomenclature – your natural bar code readers watching what’s in your blood to sort our friend from foe.
  3. You can make great bacon with wild boar? T or F                                                  Answer: Patently false. To make bacon on pigs, you have to feed them corn and beans.
  4. To make bacon on you, the best foods to do that with are?                             Answer: Same as with pigs. Corn, wheat and beans
  5. Ipso facto, to lose weight you need to ?                                                                Answer: create the environment whereby you “stop the war”, turn off inflammation, rid yourself of lectins, eat what nature intended you to eat.

 

 

Lectin Lesson 2: How Lectins Cause Damage with Inflammation

References: American Heart Sci Meetings,Jr, ImmunologyResearchgateWikipediaAthersclerosis,

Just what is going on with lectins? What’s the big deal? Do they really cause trouble?

To understand those questions, you have to understand the complement system in your body. This is not about saying a nice thing to you about your hair, or your necklace, this is about your basic lizard brain immune system, your innate immune system. Your innate immune system is the first to respond to threats with non-specific responses. If you think of a series of dominoes, each of which knocks over two more, the innate immune system is the means by which your body kicks back immediately against external threats and makes immediate reactions that happens quickly in response to “invasion”. A cascade of chemicals create tags to place on the invader to tell a white cell to eat that particular invader, (Opsonization is the fancy term) or punches a hole in the wall of the invader with donut shaped proteins so the invader leaks its guts out. You can imagine, this has to be carefully controlled as if it balloons out of control, you get the shaft and your own cells get damaged. The adaptive system, layer two of your immune response, takes longer to gear up and make specific antibodies shaped precisely to attack the invader, or specific white cells armed with bar code readers to find and destroy the invader. Doing all that takes time. In the short term, the complement system is it.
There are several pathways into the complement system. The classical pathway, the alternative pathway and the LECTIN PATHWAY. Did you get that? The lectin pathway is one of the ways you set off your innate immune system. To understand this pathway you have to be able to read the following sentences without pausing: This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) to microbial surface oligosaccharides and acetylated residues, respectively. Upon binding to target molecules, MBL, CL-K1, and ficolins form complexes with MBL-associated serine proteases 1 and 2 (MASP-1 and MASP-2), which cleave C4 and C2 forming the C3 convertase (C4b2a). If you drill down into that, it simplifies to the sugar mannose that is part of many plant lectins, and your complement system watching for that sugar signature to fire off a response. Ficolins are protein lectins that come in patterns of five at a time, and also set of the lectin pathway.
Here is the rub. There is now evidence that a low lectin diet will decrease endothelial dysfunction (code word for the first step in coronary artery disease).

What’s the final implied conclusion? This is a new way to look at heart disease. Lectins play a roll is setting off inflammation. That’s a given. Lectins in the human diet have increased dramatically in the last 200 years as our foods from all over the world have become part of a new diet that never had those foods before. And in the 21st century, we have added all sorts of chemicals to our environment that allow our gut to “leak”: NSAIDs like ibuprofen and naproxen, steroids, antibiotics, PPIs. And we have genetically modified many of our foods to create grains resistant to insects by intentionally inserting more lectins into the genome of plants that we then eat. We have tilted the playing field. The slope is in the wrong direction to maintain health.
WWW. What will work for me. I am eager to learn this stuff. I was at a small plate restaurant this weekend and intentionally chose a low lectin dinner: grilled Brussel’s sprouts and calamari. I slept better last night. Hmmm. Don’t know if that’s linked. One meal does not a heart attack prevent, but Gundry has shown that a low lectin diet will reduce damaged blood vessels “endothelial dysfunction” in just a few months. I’ve been off ibuprofen now for two weeks. Never again.

Pop Quiz

 

  1. The Complement System is the method of English Manners and Polite Behavior. T or F Answer: well, yes, true, but not here. In your immune system, it’s your kick boxer – the first line of defense against invasion. Not polite
  2. Lectins set off the complement system. T or F                               Answer: True. There are 3 pathways to set it off and one of them specifically is started with lectins.
  3. Many lectins have a simple sugar on them that is an ID of trouble. What is it?          Answer:   Mannose
  4. You can reduce endothelial dysfunction with a low lectin diet? (What’s that?  It’s part of what we simplify to call high blood pressure, but is a bigger picture of damaged blood vessel lining.)                                        Answer:  Today’s takeaway
  5. We have had an increase in lectins in our diet in the last 100 years?                            Answer: Not only an increase by new foods, but intentionally added to many foods by genetic engineering, feeding lectins to our animals, and then the coup de grace of adding leaky gut from modern chemicals.