Galectin 3 Amplifies and Perpetuates Inflammation
February 05, 2024Galectin 3 Perpetuates and Amplifies Inflammation
Ever heard of Galectin? It's a protein that turns on inflammation and is being found to play an outsized role in diabetes. It may be the key link to the level of inflammation that you feel in your joints. It was first discovered with respect to its ability to accentuate prostate cancer, if not all cancers some 20 years ago. It is an approved test for congestive heart failure.
With more research the means by which it accentuates and perpetuates inflammation is becoming more clear. It's not just in cancer or heart cells, galactin activity appears to show up in virtually all inflammatory processes. In that context, it appears to be an accelerant. As stated in the Cell reference, "Gal-3 contributes to the initiation and amplification of the acute inflammatory response by recruiting macrophages to injury sites and perpetuates a state of chronic inflammation through the activation of proinflammatory pathways."
This is where the story gets interesting. A young boy growing up in Israel on a kibbutz had his grandmother hand him one of the oranges she grew and told him, "This will heal all diseases." The prophecy turned out to be prescient! Sure enough, when Dr. Eliaz studied citrus pectin (the white stuff on the inside of the orange peel) he found if he chopped it up into small pieces so it would be absorbed into your blood, it became a remarkable inhibitor of prostate cancer.
It would have been enough if prostate cancer was inhibited. But on a monthly basis now we are seeing papers and studies in which modified citrus pectin helps diabetes, Alzheimer's, heart disease, chronic pain. I have personally seen a patient with prostate cancer live years past his expected demise taking only modified citrus pectin.
Inflammation is elusive. We don't quite understand just why it gets started. Everything from the gut biome to visceral fat is implicated, including the kitchen sink and your father's irritating uncle. This is a non-toxic, as natural a process as we can devise, inexpensive experiment we might all benefit from.
www.What will Work for me. Modified Citrus Pectin will lower your blood sugar. How, we aren't sure. But the lower your sugar, the longer you live. If you are one of the 60% of us who have modestly elevated fasting blood glucose, you might try the experiment. If you have any form of cancer, you might consider adding this to your regimen. Heart failure? Slam dunk. Heavy metal question? It's an impressive chelating agent. But what you might really try is 5 grams, three times a day for a month to see if your chronic pain gets better. Back pain? Hip pain? Give it a whirl. No toxicity. No prescription. You can buy it online. The only proviso is that the actually chopping-up process is some delicate chemistry and not everyone does it right. The raw, unprocessed orange peel sitting in the orange juice factory recycling pile doesn't do it. The good process is owned by the company Eco-Nugenics. It's on Amazon. Orange bottle.
References: Review Endo Meta Disorders, Jr Inflamm Research, LifeExtension, Cell,, Rev Cardiovasc Med., Journal Clin Oncology,
Pop Quiz
1. What is modified citrus pectin? Answer: The pectin molecule is cleaved into smaller molecules that penetrate the gut wall and successfully get into your blood. The whole molecule remains in your gut and has modest benefit as fiber.
2. What is galectin? Answer: It is a lectin that has pro-inflammatory qualities that help cancer cells metastasize, hearts stay inflamed, and diabetes remain out of control.
3. What does MCP do to galectin? Answer: It binds to it, inactivating it and consequently reducing the perpetuation of inflammation.
4. Does it lower blood glucose? Answer: This was the gimme question. (Yes!)
5. Any toxicity to MCP? Answer: Some GI issues but very rare serious toxicity.