Category Archives: 23. Muscle Health

Are You a Food Addict? Take the Susceptibity Test

FReferences: Bright Line EatingSusan P Thompson’s Susceptibility ScaleValidation of Yale Food Addiction Score in ChildrenPhilos Trans R SocWheat FactsCornAm J Physiology56 names of sugar,

There is a growing science of measuring addiction susceptibility in humans. Criteria for being an addict include developing tolerance to a substance, withdrawal when use is stopped, needing larger and larger doses, persistent desire coupled with the inability to stop using, spending increased time to access the substance, continuing use of the substance even though you know it causes harm and giving up social or recreational activities to use the substance. Sounds dour and threatening, doesn’t it? Could this be chocolate? Or just plain sugar? 
The body of research supporting human food addiction is actually getting more robust as we look at our obesity epidemic and ponder what is driving it. Animal models of addictive eating show that rats given access to sugar or highly processed foods exhibit the classic behavioral and biological signs of addiction (e.g., withdrawal, tolerance, dopaminergic downgrading). Hmmm… For example, get rats addicted to cocaine, then expose them to a choice of cocaine or sugar, and they go for the sugar instead of the cocaine. Hmmm….. 
More to the point, functional MRI scanning of active circuits in the human brain show pretty remarkable overlap between sugar, white flour, and heroin. 
And processed food appears to be at the forefront of this addictive behavior. What’s in processed food? 80% of American food has sugar or high fructose corn syrup added to it. Often it is given a different name hoping you are willing to let dehydrated cane juice, agave, or honey trick you into thinking it’s not sugar. Some foods even boast that they have no, underline NO high fructose corn syrup, and then have pure beet sugar instead. The difference between the two is subtle, at best.

What is processing? It’s actually very simple. Take a whole grain with the surface area of the grain, and grind it into talcum powder. We call that flour – whether it be from wheat, or corn, or rye, it’s still talcum powder. 10-100 fold increase in surface area, with the encasing protective fiber also gone. When you eat it, your enzymes can get to that greater surface area faster. A whole grain will have a glycemic index below 30% of pure glucose. A grain that has been broken in half, like steel cut oats, will have a glycemic index of 50% of glucose. Just cracking the grain in half increases the ability of your enzymes to access the glucose packed in that grain. But crush the grain flat and call it “Quick Oats” and you increase the surface area enough to increase the glycemic index to 70-80, depending on how finely you crush it. You put out insulin in an increasingly rapid fashion in response to the rapid glucose rise. Insulin blocks leptin in your brain stem, making you want to eat more. And there you have it. Any grain will do the same. Corn is just about the foundationof everything we eat because of its use in animal feed.

But wheat occupies a special place in addiction. Not only is it made into talcum powder but that talcum powder is put into about every package or processed food, be it pasta, gravy, bread, crackers, cookies, or any other form that leads to the 6 oz of wheat flourwe each eat every day. And wheat has wheat germ agglutinin (WGA) in it and that is a special devil. It is an insulin agonist/antagonist, leading to more insulin binding to fat cells, less to muscle cells and more leptin blocking, all of which engineer weight gain and more addictive consumption.

With all that hitting you when you eat processed foods, is it any wonder that you act like an addict? It’s almost amazing we all aren’t.

Do you want to take Susan Thompson’s quiz? This is the link. I’m not sure it’s the final word in understanding why we overeat, but it sure gives you some insight into why we all have so much trouble losing weight. She claims that about a third of us are not affected by addictive tendencies, about a third are modestly affected, and a third are rabidly vulnerable. That would be me. All of us can act with addictive tendencies, given constant exposure and reinforcement.

WWW: What will work for me. I took her quiz and scored an eight. Ha! That explains just why it is so easy for me to start with 8 chocolate chips, then return for 45 more, then finish off the bag. And that done only when there are no human witnesses. The dog, fortunately, doesn’t tell. And I know I won’t sleep well when I do it. And I’m fully aware it’s awful for me. But, but, but……

Pop Quiz

  1. What percent of humans are vulnerable to food addiction? Answer: All of us, given enough exposure though only about a third show a particular penchant for it.
  2. What are some of the features of addictive behavior? Answer: developing tolerance to a substance, withdrawal when use is stopped, needing larger and larger doses, persistent desire coupled with the inability to stop using, spending increased time to access the substance, continuing use of the substance even though you know it causes harm and giving up social or recreational activities to use the substance.
  3. What is the link with flour products to addiction? Answer: the more a grain is ground up, that easier it is to digest, and the faster blood sugar goes up. That results in greater insulin release, resulting in more leptin blockade and fat storage
  4. Explain to me what WGA is? Answer. Wheat germ agglutinin is a small protein in wheat germ that messes with your insulin receptors, pushing calories into fat but starving muscles. This results in disordered glucose management, and makes for your gaining weight and developing diabetes.
  5. Dehydrated cane juice is safe to use as it is a dryer form of sugar. T or F Answer: Please, please, please tell me that you didn’t fall for that. There are over 56 names for sugar. If you answered yes, click this link and learn the other names.

Mitochondrial Primer 5: Beta-hydroxybutyrate, The King of Ketones

References: Front Mol MedWikipediaPerfect KetoAm J PrimatologyPeer JBiochemical Journal,

When you burn fat (the stuff that’s in your belly and cellulite and second chin) you produce two ketones primarily. Ketones are what we make from fat burning as we break down stored energy and ship it around the body. The primary one is called beta-hydroxybutyrate, or BHB. The other is called acetoacetate (ACAC). ACAC is what you measure in your urine to show ketones but can be changed to BHB, and thereby not show up in urine. Hence, measuring urine for ketones is iffy and can have false negatives. BHB takes a blood test and is more reliable.
Now, what I find interesting is the enzyme that switches ACAC to BHB and thence into the electron transport chain is actually in the wall of mitochondria. Ketones are such an important part of normal metabolism that mitochondria have all the normal enzymes to incorporate ketones into our energy flow. Did you get that? Our body has all the tools to burn ketones, all the time. It is built in. Through all of human history, ketones were our main fuel source to fall back on in lean times.

What happened in our rich, 21st-century environment? We never, ever run on ketones. There are no lean times. We always run on carbs. We store up what and corn in giant silos, formulate them into delicious foods and provide them to ourselves three times a day in exquisitely flavored recipes. And our body has a default switch that has us burning and running on carbs preferentially. It’s the universal signal to turn on fat making, storage.
This is the key to weight gain and weight loss. Our natural tank of carbs is only 1500 calories. That’s it. Anything over that and we signal our hormones that we have too many carbs. That means it must be September or October when carbs ripen – at the end of the growing season. Our blood sugar rises. We turn on insulin. Insulin switches everything into storage mode. We make triglycerides in our liver and ship those extra fats all over our body in little lipid bundles called LDLs. LDLs then deliver that newly manufactured fat to storage warehouses called your butt, your chin, your muffin top.

Think this through teleologically. We had to be designed like this to survive in a world where carbs show up suddenly, just before the starvation season. We would then evolve a hormone to store those calories when they showed up in abundance. (That’s where insulin comes in.) And we would be favored to have sweet flavor in the middle of our tongue so that we seek carbs avidly, whenever we find them.
But most of the year, we should be running on ketones. Normally. When you are surviving through winter, you are meant to be burning your fat stores. That’s ketones. When you eat green vegetables (present from April till August), your colon turns spinach into ketones. Gorillas, eating 15 pounds of green leaves a day turn those into 70% ketones.
Now there is a whole raft of websites touting the increased performance of athletes on ketogenic diets, how to induce ketogenesis etc. But most importantly, we are proving that inducing ketosis turns on stem cells. It’s so important to run on ketones, Bredesen is insisting we all do it every day for 12 hours and every month for 5 days. Gundry has jumped on board. The tide is changing.

Ketones, otherwise known as Beta-hydroxybutyrate (BHB), are your main, proper food source. BHB rules. It’s the boss! And teaching your body, encouraging your body, forcing your body, manipulating, managing, teasing…..whatever you want to call it…..but do it. Get your body to run on ketones. That means, no grains, no sugar and lots and lots and lots of green vegetables.
WWW. What will work for me. I’m wrapping my head around this technology. I’ve done the Fast Mimicking Diet 8 times and found that it jump starts me into ketosis in three days. I’m going to try taking some Beta-hydroxybutyrate supplement the next time and see if it eases me into ketosis with a little less stress. What I do believe is that this is the pathway forward. Our bodies are aching for us to break our addictive habit of carbs. It just wasn’t meant to be so. The only time we were meant to gorge on carbs was at the end of the growing season when getting ready for winter. Brings a whole new meaning to Halloween candy. Doesn’t it? So, we ended up at the Pancake House for breakfast. I ordered the Eggs Benedict with spinach on the side. Didn’t eat the English muffin. Double spinach please, no potatoes.

Pop Quiz

  1. The human primary fuel is?                                             Answer:  Beta-hydroxybutyrate. The ketone you make from burning fat, your colon digesting green vegetables, the ketone you make from digesting coconut oil, olive oil, avocado oil……
  2. Exposed to carbs, your body will switch to what fuel? Answer: Glucose. Instantly. The microsecond you put out insulin. Three french fries will do it.
  3. Running on insulin instantly is incredibly important. Why? Answer: Because through most of human history, carbs were rare, and present just before the lean, starvation system. Remember, pears and apples ripen in October; right now. So sugar is on our tongues as our preferred taste so we gorge, turn on insulin, store calories and then…survive through winter.
  4. How big is your carb fuel tank?                                                   Answer. 1500 calories, called glycogen. Fill up that tank with…….one plate of pasta, rice, flour.
  5. And what happens to green vegetables?                                 Answer. Your colon bacteria break them down into beta-hydroxybutyrate. The King (or Queen) of Ketones. BHB rules. You’ll have BHB anytime you fast 12 hours or more. You will have a blood level of 3 and more if you do the fast mimicking diet for 3+ days. The Fast Mimicking Diet: best way yet to get you in ketosis.

Mitochondrial Primer 4: Role of CoQ10

References: Mitochondria and Future of MedicineMortenson JACC Heart FailureLangsjoen Biofactors,

You should know what CoQ10 is by now. It is in every mitochondrion, in every cell in your body. Ubiquitous. It sits between Complexes 1,2 and 3 and passes on electrons, thereby playing a critical role in the electron transport chain. About 2% of electrons escape the electron transport chain, and CoQ10 soaks those escaped little electrons up before they can cause damage. You make lots of it when you are young. You make much less when you are older. It was discovered in 1957 and in 1972 the level of its deficiency was linked to congestive heart failure. Many cardiologists got interested in it and it became a widely used supplement, particularly with statins and muscle pain.

Initial studies of it were not exactly positive, perhaps because lab measurements were not as precise or available as they are today, thereby leading to inconsistent doses. But the Mortenson JACC study showed that 100 mg three times a day compared to conventional drug therapy alone reduced CV mortality by 42%, and all-cause mortality by 44%. That caught people’s attention.
Dr Sinatra has been one of its most prominent advocates and claims that the threshold of effectiveness is 2.5 ug/ml, and that one will not see much clinical benefit below that. He laughs off older studies that do not mention or measure blood levels. I personally see most folks with levels of .7 and 1.2 with very few above 1.5. Hmmm. As we age, we are all deficient.
The other controversy about CoQ10 is whether one should take the common cheap form, ubiquinone, or the fancy expensive stuff, ubiquinol. They do switch back and forth in the body quite easily, but the -ol form is a more potent anti-oxidant. The manufacturer claims that the expensive form is worth it and backs it up with a very small study of 7 people who had failed with the -one. In that study, the average ejection fraction went from 22% to 39%, and their average New York Heart Association CHF class dropped from IV to II. Very impressive. A very small study, not blinded so open to lots of problems.

The number two reason to visit a doctor is “fatigue”. If your mitochondria are weakened by low protection secondary to low CoQ10, one will have decreased heart pumping which will mean decreased delivery of blood to muscles. In muscles, the same low CoQ10 level will result in reduced muscle ability. We call that fatigue.

www.What will work for me. What I think is going on is that most folks never get to the threshold of effective therapy. With random dosing of CoQ10 from variable sources, I suspect some folks just aren’t getting enough, and some folks are getting knockoff CoQ10 that isn’t even the real drug. With the ability to measure its level, we can now really check. A starting dose should be 100 mg 3 times a day. And then ask your doctor to check the level. You are looking for a level of 2.5. Nothing less will do. If less, double your dose. Check again.

Pop Quiz

  1. What is the role of CoQ10 in the mitochondria?                      Answer: two roles. 1) Passing on electrons between complexes in the electron transport chain, and 2) catching loose ones that get away from the electron transport chain.
  2. What happens to CoQ10 levels as we age?                               Answer: Drop precipitously.
  3. How much will a heart’s ability to pump increase if you get a level above 2.5?            Answer: Mortenson’s study showed over 40% reduction in mortality and a very small study of the reduced form showed a 22-39% increase in cardiac output.
  4. What blood level of CoQ10 do you want for yourself?             Answer: 2.5 and above
  5. And what is the dose you need to get that?                               Answer: Start with 100 mg 3 times a day. Then test and then double the dose.

Mitochondria Primer 1

References: Mitochondria and the Future of Medicine,

You need to know what mitochondria are. Why, because they decide when you live or die. They are at the nexus of your brain being healthy. They provide your energy. So what are they? Energy factories. They are tiny organelles inside each and every cell that make your energy molecule called ATP.

They probably result from the fusion of two bacteria two billion years ago. One took up residence in the other, and was able to stay because it helped the other. It had learned how to burn energy from fat in what we now call “the electron transport chain”. In that chain, the new resident was able to extract the latent energy in fat by shifting the electrons across membranes and grabbing the resulting energy in the form of a molecule called ATP. ATP has three phosphate groups lined up that can carry the energy around for use elsewhere. The boost of energy production was from 2 ATP per glucose to 38, 19 fold! A regular human cell can only make 2 ATP per glucose without its mitochondria. We could never have evolved such delicate, magnificent cells if we hadn’t first gotten a reliable source of energy. That partnership of those first two cells was the beginning of complex life on earth. Each mitochondria today has about 10,000 electron chain complexes in it, processing our fuel needs one ATP molecule at a time. The proteins in the chain are lined up in a precise complex allowing energetic electrons shed their energy to be captured by the transport chain and then attached to ADP molecules with two phosphates, remaking ATP with three phosphates.

Over the millennia, the new resident gradually lost most of its own DNA, depending on its host to provide most of its genes, except for the very critical few that it needed to decide when to make more energy, or when to make less. “When to hold em, when to fold em”. And it hung on to 10 sets of those 37 genes (compared to 22,000 proteins in humans) in each mitochondrion.

The human cell is incredibly complex and very energy dependent. We would not be what we are without our little power plants chugging away. You are 10% mitochondria by weight. A human egg has 100,000 of them, lying dormant until fertilized when the 100 mitochondria from a sperm get knocked off. Hence, all your mitochondria come from your mother. We can trace your maternal lineage through your mitochondria, not your paternal. Muscle cells of athletes have 300-400 while us couch potatoes have only 150-200. (Getting in shape builds more mitochondria – of course!) Heart cells have 5,000, as does the brain. But the retina is probably the champ at 7,000 per cell. Vision is hard work. And aging eyes get mitochondrial diseases we call macular degeneration.

Is that enough for one week? Reread this letter. Learn it. We all need to know how to manage and care for our mitochondria.

www.what will work for me. I’m trying to bring the concept of mitochondria into my practice. We all should know about them and how to care for them. When I treated my father’s mitochondrial disease called congestive heart failure, his ejection fraction improved dramatically by about 30% and lived 5 years longer than his projected lifespan. Considering that 50% of us have some congestive failure when we die, and that is a mitochondrial disease, should be enough to convince all of us that the care of our mitochondria is important. Hence, this series. Part 2 and 3 still coming.

Pop Quiz

  1. How much a boost to energy supply did mitochondria provide?                   Answer: 19 fold
  2. You can track your genes for your family most accurately through what modality?    Answer: Not Ancestry.com,,,,,your mitochondria. You can read all about “Mitochondrial Eve” to see how we figured out that humans came out of Africa about 90,000 years ago, having started somewhere in Ethiopia.
  3. What cell has the most mitochondria of all?                                                  Answer: the female ova, otherwise the retina.
  4. If your heart can’t make enough energy to pump blood, what clinical disease do we call that? Answer: Congestive heart failure. which 50% of us have when we die. Makes sense. You die when your heart poops out. Your heart poops out when its mitochondria can’t supply the energy you need.
  5. What happens in your muscle cells of your leg when you walk every day at least two miles? Answer: Build more mitochondria: aka, getting in shape.

Lectin Lesson #3: How Lectins Make you Fat

Reference: Gundry’s The Plant ParadoxAm Jr Physiology,

Did you know that humans lost height and brain case size in the 1000 year transition from hunter gatherer to wheat grower. Gundry quotes this in his book as what has been discovered at archeological sites from those time periods. Civilization had its costs? All so that we could have kings and cities and armies and compete with your neighbors more effectively. Hmm. And we started domesticating pigs and cows, sheep and goats….so we didn’t have to go hunting. Here is Grundry’s conjecture. Wheat and lentils are amazing grains. When you eat them, you gain weight faster and more efficiently to that you can make it through winter more efficiently. Civilization liked wheat, because by putting calories on into storage, those who ate it lasted longer.
Now, extend that to today and see if it’s any different. What do we feed cows before we slaughter them for market – corn and beans? Wild pigs are lean animals. Domesticated pigs have lots of fat (we call if bacon) when fed corn and beans. Those foods make animals fat too. So Gundry’s hypothesis is that humans didn’t choose wheat and lentils to grow because they could be stored, but because you put weight on the most effectively with them. That’s his Plant Paradox. The very plants (wheat and beans) that allowed our ancestors to develop civilization and store calories for the winter were the same plants that hastened our demise from metabolic diseases. Now, that was hidden for the last 9,000 years because we died of measles and tuberculosis and cholera by age 30 anyways, and didn’t see the degenerative effect of inflammation caused by these grains. Grains became the means to civilization not because they could be stored, but because they were the most efficient means to put on weight and make it through winter. They promote more calories into fat deposit than any other food. And then, isn’t it curious that milk from black cows, so called A-1 milk, has lectin qualities to it too in its BMC-7 fragment, and promotes weight gain.
Ok, I get the historical conjecture but is there a coherent biological explanation for how this works? Yes, indeed. It goes as follows. Two key processes are going on.

First, the disruptive effect of the lectin in wheat called WGA. Wheat germ agglutinin. It looks a lot like insulin. Acts like insulin. That’s what lectins are, proteins that mimic mammalian proteins and cause damage by disruption. WGA mimics insulin, badly. Insulin attaches to a cell for a tiny amount of time, then lets go. WGA doesn’t let go. On a fat cell, the message is to take up glucose, forever and ever. That fat cell gets fatter. On a muscle cell, however, the message is to block insulin effect so muscle are starved. Again, WGA doesn’t let go so the real hormone that should be on the receptor can’t dock on its receptor and tell the muscle cell to take up glucose and run with it. Same effect on nerve cells: WGA clamps on and doesn’t let go. Nerve cells are starving. But they send out the message to the organism: “Eat more.”
Even more disturbing isrecent evidence has emerged that lectins can climb up the vagus nerve from the gut to the brain, damaging the substantia nigra, the seat of Parkinson’s disease. Indeed, cut the vagus nerve and the risk of PD drops 40%.
The final argument to support Gundry’s hypothesis might be called the Common Soil Hypothesis – that the mechanisms of metabolism and inflammation are curiously linked. You got fat because your body is at war with itself. And it goes as follows. The lectins set off your “Tiny Little Radars”, your Toll Like Proteins, that reside in your blood vessels and fat cells. They set off cytokines (your body’s fire alarms) calling for white cells to respond to clean up the invading bacteria. Except there are no bacteria. It’s just lectins. But the white cells show up. And your body shifts into war mode. Energy goes to the troops, the white cells. The stay-at-home folks, (Gundry calls them civilians but you think of them as muscle and brain cells) go on war rations and get less. Hence, you become insulin and leptin resistant not because you are overweight, but because your body is inflamed from all the fake lectin signals setting off fire alarms about invading bacteria. Your body is at war, thinking you have been invaded by bacteria, and you are all pumped up and ready to defend. Except that there is nothing to defect. The home folks starve. Fat cells get bigger.

Get it? Stop the war, send the troops home. Weight loss follows automatically. Stop eating lectins. That includes A-1 milk and cheese, nightshade plants, wheat and beans and most of all, genetically modified foods with their genetically inserted extra lectins.

www.What will work for me. This is a paradigm shift type of thinking, but it makes perfect sense. I get it. I just have to figure out how to implement it. And wheat is lurking behind every food in America. And every meat product was raised on lectin foods: corn and soybeans so the lectins in those foods are still there for me to absorb. I have to live with this a while. But I can shift a little. Less beans, less wheat. One step at a time.

Pop Quiz

  1. You are leptin resistant and fat because you eat like a pig? T or F                      Answer: That’s backwards, unless you take eating like a pig to mean you are eating corn and beans, lectin foods. The proper answer is that leptin resistance and fatness comes from the natural shifts your body makes to counter the fake messages caused by eating lectin containing foods. You eat secondarily because your brain cells and muscles are starving, ironically.
  2. Lectins set off inflammation because they activate TLRs? What are TLRs?
    Answer: Toll Like Receptors or “Tiny Little Radars” in Gundry’s clever nomenclature – your natural bar code readers watching what’s in your blood to sort our friend from foe.
  3. You can make great bacon with wild boar? T or F                                                  Answer: Patently false. To make bacon on pigs, you have to feed them corn and beans.
  4. To make bacon on you, the best foods to do that with are?                             Answer: Same as with pigs. Corn, wheat and beans
  5. Ipso facto, to lose weight you need to ?                                                                Answer: create the environment whereby you “stop the war”, turn off inflammation, rid yourself of lectins, eat what nature intended you to eat.

 

 

LifeSpan versus HealthSpan

LifeSpan Versus Healthspan

References:  WEForum 2017Compreh Physiology 2012,  Med Sci-Fi Sport Exercise,

We are living longer. But are we living better? In the 20th century, we doubled our life expectancy with the miracle of antibiotics, clean surgical technique, X-rays, immunizations and clean water.  Babies being born today in advanced societies have a 50:50 chance of living to be 100. But living longer isn’t necessarily better. There have been some disturbing trends lately. Obesity has managed to reverse the climb to longer lifespan in some societies, namely the USA.

As we live longer, we have more choices about lifestyle, making research into factors affecting confoundingly complex. It becomes impossible to do “randomized, placebo controlled” studies over decades without limiting free choice and spending more money than could be allocated. This article, from the World Economic Forum this year, offers insight into the laboratory of fitness, namely masters athletes. I have a dozen or so men and women older than 60 in my practice who would qualify as exceptionally fit. And I see their lab results and their vitality. They are aging differently than those of us who are less active.

Sedentary behavior is being increasingly recognized as the driver of many of our modern conditions. Part of this discernment comes from the recognition that athletes, (high end performers) have a disproportionately share of good health. They don’t get in trouble. They still die, but their time of end-of-life disability is markedly compressed, compared to the majority of the sedentary population. They become a unique research cohort, one that we couldn’t duplicate with “randomized research”. In effect, what happens with athletes is that they reach their peak in their 30s, like all of us, but then don’t show much decline until close to the very end. The rest of us show inexorable, linear decline. “Patch, patch patch, after 40!,” we say.

At every age in life, starting exercise of any kind has benefit. And the risk of complications from exercise is far lower than the risk of remaining sedentary. The real risk is sitting. Considering computer games at home, TV, computers at work and cell phones in-between, we are mesmerized by electronic distractions that leave us sedentary. In fact, research in 2009 of 17,000 Canadians of all ages showed a dose relationship of sedentary behavior to all cause mortality, regardless of levels of exercise. That means 30 minutes in the gym does you no good if you are sitting the rest of the day. Bother.

The Author cites four strategies with references on each: 1) Move More (Just get started and move more), 2) Move Slow, (Aim for 10,000 steps a day) 3) Move Fast (Add some high intensity something, even for just 10 minutes) and 4) Move Heavy (Add some weights). Read those hyperlinks. It’s the best of our knowledge.

WWW.What will work for me. Sedentary behavior is the new smoking. If you want to live better, longer, you have to do it. Build it in every day. A day without exercise is as bad as a day of smoking.

Pop Quiz

1. Our grand-kids are likely to live to be 90+. T or F Answer: False if they are sedentary, but true if they get the exercise bug and take care of their diet.
2. Our society is becoming more active. T or F Answer: Mixed picture. But as a general rule, false. Bless those who make the answer slightly true.
3. 30 minutes at the gym has beneficial effects? T or F Answer: Sure, it helps. Its benefit may be completely erased by an 8 hour day of sitting.
4. There is a dose relationship between exercise and good health. T or F Bingo
5. Getting sweaty isn’t necessary. T or F Answer: False, if you want optimal results. Getting sweaty 3-4 times a week is much better for you.

 

Lipotropic Shots: Fact or Fiction?

Lipotropic Shots: Fact or Fiction

References:  Priority HealthEmpower PharmacyHepatologyAmer Jr Clin NutrBlood Review,

Ever heard of lipotropic injections? I hadn’t, until a few months ago. When a client came to me and asked if I would give them to her, because her doctor in Arizona was using them and she could lose weight with them, I paid attention. When I was asked a second time, I sat up and started reading.

The literature goes back to the 1930s when fatty liver started raising its head as a problem. Charles Best was researching how to help the liver recover from fatty liver. It was his initial research that sparked interest, and discovered many of the agents that worked. Today as many as 50% of Americans over age 60 have fatty liver without even knowing it. It slows down our energy flow, our ridding of toxins, our efficient burning of fat.

We see it as being overweight, and wanting to lose weight. Well, who doesn’t want to do that? What do the shots do? They combine the compounds that have been found to increase your liver’s efficiency of metabolism. The benefits are considered to be the preservation of muscle, the burning of fat, the enhancement of energy and the improvement in liver function. The ingredients include methionine, choline and inositol, along with all the B vitamins and l-carnitine. The ingredients work because together, they have a synergistic effect. And many aren’t well absorbed from the gut. Hence, a shot. Many folks include betaine as an oral supplement along with the shots to enhance it even better. That is well absorbed orally.

From what we now know of mitochondrial function, this is exactly the process of helping the mitochondria access and burn energy more efficiently. In fatty liver, our liver is all clogged up with little fat globules, inhibiting the liver factory from working efficiently. With the ingredients of the lipotropic injections, your liver’s mitochondria start clearing the liver of backed up fat and your peripheral mitochondria to be able to burn more of it.

Suddenly, my lights turned on. All the literature I read shows that lipotropic injections improve the methionine cycle, and help lower homocysteine. So, now I get it. I’ve been trying to help folks lower homocysteine to improve risk of Alzheimer’s disease. Many of us have homocysteines hovering in the 10-12 range, some even higher. For every point over 7 of homocysteine, your risk of AD goes up some 16%. The narrative we use with Alzheimer’s is that we want your brain to learn to run on ketones, or fat. To do that, we need to cut carbs and increase the efficiency of our methionine, homocysteine cycle.

Son of a gun, the Lipotropic Shots do that! Coming at it from a different way.
So, maybe they are fact. The fiction part of me suspects that this is a bit of marketing hooey. Can’t you get all this from food? What does it take a shot to get it into you ?

WWW. What will work for me. I’ve ordered all the ingredients for my office and I’m going to run an experiment for myself. I’m looking for some hard nosed skeptics, who want to lose weight and who are willing to give themselves a shot every week/day. If you are willing to do this, I will set up a regiment of shots for you for cost. I want to take the first 5 people who give the office a jingle and are willing to give feedback. I want your weight before and after 12 weeks of shots. You have to keep exercising, cutting carbs and eating sensibly. Let’s see if this old fashioned idea still has legs.

Pop Quiz
1. Lipotropic shots have ingredients that reduce your ability to burn fat and help you burn carbs? T or F False. Go back and read the column. It appears that lipotropic shots increase the ability of your cells to turn all energy, and preserve muscle.

2. Lipotropic shots got their name from research in the 1930s aimed at reducing fatty liver? T o F True

3. Today, we understand that lowering homocysteine has some overlapping effects, as both processes are aimed at enhancing the methionine, homocysteine cycle, that helps your body get rid of toxins and burn energy more effectively? T or F True

4. Can’t you get all this stuff from food? Apparently not.

5. Is this just a marketing gimmick? Let’s try and find out.