Category Archives: 22. Toxins

Statin Rage

Statin Rage

References: QJMPharmacotherapyPharmacotherapyTrans NeurodegenAm J MedATVBScientific AmericanGraveline,

You know statins are widely advertised as being good for your heart. And the literature supports that if we look at you as a “walking heart” with little more attached on the outside. Considering that the house of medicine makes the most money off you for heart disease, cardiologists hold a lot of sway over the health care system. Hence, when the heart doctors (aka medical “God”) say, “Thus spoketh….., thou shall take statins!” the house of medicine snaps to attention and does so. I’m not here to argue the whole case, just the case of cognitive damage as shown in “statin rage”. These are not innocuous drugs, and you are more than just a heart. Your brain might be important too. If you act like a jerk, your love relationships suffer and they might be more important to you than your arteries.
What does the literature say about cognitive effects? Quite a lot actually. What caught my attention was a plea from a client who has repeatedly felt terrible anger when exposed to statins. And he is a very high risk for heart disease, and “needs” his statin. Or does he? Is there another way? (Hint: YES!!)
I reviewed several studies. The first in Translational Neurodegeneration suggests there are two competing processes going on. They review all the studies of cognitive decline, and find design problems with all the studies: for example, most patients in some studies are on low dose statins whereas high dose is what makes the side effects, and most patients are actually on higher doses. But they end up concluded that there really are some folks who get pretty severe memory issues, and get better when the statin is stopped. They plead that we be aware of those effects and be brave enough to stop the statin if memory issues occur. Just stop!
In the QJM study, four patients were found with “manifestations of severe irritability” included homicidal impulses, threats to others, road rage, generation of fear in family members, and damage to property. All got better on stopping the statin, and worse again when it was restarted. Conclusion: be brave enough to stop!
There is more. Scientific American has a nice review on memory loss and statins. Duane Graveline, NASA astronaut, lost his memory for the duration of being on statins and wrote a book about it. You might want to read that book if it catches your eye.
www. What will work for me. Loss of memory, road rage. How much can you take? These effects may not be common, but they are indications that there is brain damage/effects of taking statins. And published studies in randomized fashion of cognitive ability again show damage, albeit not that commonly. One could ask, just how well do the people selling the drug report of effects that could damage their sales? Only you can answer that one. As for me, I’ll change my diet to avoid taking statins. There are other answers that are just as effective. For example, consider Gundry’s report at the American Heart meeting just a month ago. Hmmm. Cheaper, better, no side effects.

 

Pop Quiz

  1. Statins can damage your brain. T or F                                     Answer. True as shown by memory loss, cognitive decline, rage, and mood…….
  2. The only organ that matters in your body is your heart, and as long as you let your heart be the only organ that is talked about, statins are useful. T or F                 Answer: Ok, do you get the irony?
  3. Randomized studies, conducted by the folks selling a product, are likely to be absolutely clear about picking up pervasive, subtle shifts in cognitive ability?       Answer: Can you tell that I’m on a rant here? I’m deeply skeptical about the integrity of our pharmaceutical industry, considering their demonstrated history.
  4. Is there a role for statins?                                                                              Answer: I think there is. Someone who wants to keep eating donuts and ice cream, sugar and white flour, and has had a heart attack, likely needs to be on a statin. Those willing to eat differently and let their lab tests, including their cholesterol, be their guide, there are choices.
  5. How common is statin rage?                                                                 Answer: Rare. It’s there, but not common. Many other brain effects. It’s a “no brainer”. Gotta stop.

 

 

The Case Against Alcohol

 

The Case Against Alcohol

References: The LancetCNNCell Commun SignalScience,

This is no small study. Using 694 “data points” for alcohol consumption by populations and 592 prospective and retrospective studies on alcohol use from 195 countries, projections were made about the total and real risks of alcohol. This is an important study because it shifts the overall net balance of alcohol’s effect to negative from positive. They looked at 23 health outcomes against alcohol use and developed a new method of assessing what is the lowest risk point for consumption (aka, what can you get away with).
For decades, we have been saying that a drink a day was good for you. Maybe not for women, but generally ok. That changes now. The data is hard to deny, much as alcohol itself makes us want to say it is ok.

The details are as follows. For the age group of 15-49 which generally doesn’t die of diseases, alcohol is the leading cause of death when you take into account accidents, suicide, overdose and everything else (bar fights, drunk driving, domestic disputes). Women, ages 15-49 have a 3.8% chance of death from alcohol and men a 12.2% chance of death in that age range that can be attributed to alcohol. With that sort of granularity, reading the study gives you confidence that the authors did a pretty deep dive to get to these conclusions.

For older folks above age 50, the rise of cancer in relationship to alcohol consumption becomes the driving statistical engine to bring the net benefit to zero. Zero. There is no safe level. Young or old. No safe level.

Now, guess what the alcohol industry has frantically said in response….you got it. They quote the American Heart study saying a drink a day keeps the doctor away, etc. Even the vaunted Harvard Men’s Health Study had one drink a day as part of their formula for extra longevity. The problem with all those studies was looking at JUST one condition, like death from heart attack, instead of the whole spectrum.

And the data is equally clear for alcohol and driving. No level is safe. No level.
Now, I’m curious about mechanism and what’s behind all this. I think the clue comes down the Longo’s research into longevity and resiliency. His research shows that alcohol turns off mTOR, the gene that builds protein and cells. Growth and development helps you reproduce and make babies, but inhibiting it helps you live longer. Yin and yang. Dietary restriction is hard on reproducing but great on living longer. Alcohol turns it off living longer. Bummer.

Is there a benefit to alcohol? Well, yes. When structured in cultural practices that use it to create community, enhance connection and love between humans, that’s good. It’s a pretty slippery slope. Seeking pleasure is a universal force. Comes with a price.

www.what will work for me. Lousy puritanical message. I heard so much of this in my conservative boarding school background. It’s wearingly tedious to admit that those rigid old Victorians were right. I’m no tea-totaller. But I’m cutting down. One drink, only when I go out with friends. Time to back peddle down to two drinks a week, not one a day. And only in the social context of having a meal with loved ones. And then not driving with my loved ones with alcohol. Grrrr.

 

Pop Quiz

  1. One drink a day will help you live longer. T or F Answer: Used to be called true, now called false.
  2. Why the change? Answer: When you take into account all the conditions like trauma, domestic violence, traffic accidents as well as everything else, you fine other causes of death that statistically contribute to higher death rates.
  3. What was the prior error? Answer: If you would focus only on heart attacks, well yes, there are a few less. Or just one age group.
  4. Is there blowback against this data? Answer: Hell doesn’t freeze easily. The alcohol industry is bigger than we are.
  5. What is a prudent person to do? Answer: Love and connection is what life should be about. Cherish your loved ones. Don’t drink and drive, but do create community, family, dinners together, connection, sacred spaces. Have some communion together. And maybe that much alcohol……..0.25 oz communion wine.

 

 

 

Inhalational Alzheimer’s

Inhalational Alzheimer’s

References: Bredesen Aging,

Inhalational means caused by breathing. How awful and how insidious! But that’s exactly what this article is about. The primary cause is mold biotoxins, though other toxins will carry out the same effect. Indoor pollution is worse than outdoor pollution and our homes are so airtight now, we often have levels of toxin in the air that far exceeds the level of mold toxins outdoors. The whole biotoxin pathway gets activated and sets in motion the illness now called CIRS (chronic inflammatory response syndrome). Now, only 25% of us have immune systems that are vulnerable to this risk (generally), and 2% of us are exquisitely sensitive. That can be determined by assessing your HLA genetic haplotype.

The diagnosis of Alzheimer’s to date has been a death sentence. As we age, more of us get it and for those of us who make it to 85, we have roughly a 50% chance of being a victim. Inhalational Alzheimer’s fits into Bredesen’s Type III Alzheimer’s that usually presents without family history, without obvious memory loss as its cardinal feature, but more likely with trouble word finding, calculating or executive functions after a period of intense stress, such as andropause, menopause, anesthesia for surgery or other major stresses and is so often accompanied by depression that it is not easily recognized for its cause. It is not uncommon to find abnormal zinc and copper ratios and low pregnenolone, cortisol and DHEA-s with it and imaging of the brain shows damage to other parts of the brain than just the hippocampus.

In this article, Bredesen gives a nod to Shoemaker’s protocol and relates the case histories of patients affected by this pattern of illness. What is most enthralling is that the folks get better! Better! Yes. Slowly. There is brain damage. It takes time and most of all takes being removed from the environment that got them in trouble in the first place with the inhaled mold spores. But it makes addressing and treating CIRS a critical element of any effort to reverse Alzheimer’s.

WWW.What will work for me. Well, I just bought a very expensive meter that can measure the number of particles in the air in my home and office. I’ve been running back and forth to see if its reliable. My home has 200-300,000 particles per cubic foot. My basement hits 450,000. I’m told some juicy basements will reach 4-5 million. When I hold the meter over my cool HEPA filter, it only reads 20,000. Every time I take a breath, I breathe in half those numbers, as I inhale in the range of half a cubic foot of air with a good breath. So, I called a HVAC guy to put in an industrial strength dehumidifier and bring in outside air for our AC and furnace. He said I should think about UV light air treatment too as that kills off all sorts of stuff too. Stay tuned.

Pop Quiz

 

  1. Indoor air is dirtier than outdoor air? T or F             Answer:  Sad, but true
  2. The most common biotoxin that damages humans is? Answer:  Various species of mold, not determined yet which is the primary culprit.
  3. How many of us are at risk? Answer:  25 % are genetically vulnerable, 2% exquisitely so.  But enough exposure can get almost anyone sick.  The fact that it’s not an obvious majority has allowed this condition to slip below the radar.
  4. Inhalational Alzheimer’s defines what? Answer:  Those people in Bredesen’s TYPE III Alzheimer’s called Cortical or Toxic that doesn’t have memory loss as its primary symptom.
  5. Every time you breathe, how many particles do you breathe in that could include mold biotoxins? Answer: You don’t know until you measure but a clean home will typically have 150,000 particles per cubic foot, and you breathe in a quarter to a half of that. That’s the fine dust we call dust bunnies under your bed or dresser, or on your computer screen.   You can measure your own home’s safety by ordering an ERMI (Environmental Relative Mold Index) test from www.mycometrics.com.  A score over 2 means your home is a problem.

Chelation Therapy for Coronary Artery Disease – the TACT Study

References: NIHJAMAAHA, EHP,

Imagine my surprise when a doctor calls me and asks me to do chelation on himself for coronary artery disease. He referenced the TACT study which I had not read. Now I have and here are the results. I’ll try and put it into the context of risks and what is going on.
Chelos is Greek for claw. Chelation is making a chemical claw around a substance that is otherwise inert, dangerous or insoluble. Lead meets the inert quality. Iron meets the dangerous criteria. Chelation has been used medically to reduce both of those substances when they are toxic. But there is conflicting evidence about iron levels and risk of coronary artery disease and recent trends of studies appear to be on the side of it NOT being a problem. This flies in the face of initial enthusiasm about iron reduction, like that generated by the Finish study showing an 88% reduction in risk by frequent blood donation. This study from Helsinki followed 2,862 males aged 42-60 for 9 years. Heart attack rates for blood donors was only 0.7%, compared to 12.5% for non-donors. It’s hard to get that sort of effect unless something real is going on. Now, they didn’t account for the frequency of saunas, which many Finns do (building codes in Finland require every new apartment and home to have a sauna built in it). One study from Finland showed that frequent saunas are as beneficial as exercise for reducing heart risk.
What does chelation do? It sucks bad things out of your body by enveloping the target chemical, making it water-soluble by that envelopment, and then excreting it. It’s not just iron that gets enveloped. It’s whatever happens to be around. Lead is one of those enemies. The evidence of lead and hypertension is very strong. The subsequent association with coronary artery disease isn’t quite as robust, but is also strong. Both lead and iron get chelated when exposed to the chelating chemical, typically EDTA. But so is cadmium, mercury, thallium, uranium and on and on. All of these metals are dangerous and to date, not having been studied much. We just don’t know data on multiple, combinations, and likely never will. Research questions tend to focus on one variable at a time.
How do you do chelation? Properly done, you take mineral supplements before and in-between treatments (a fortified vitamin pill). EDTA is given by IV over about 3 hours once a week. And get a reverse osmosis filter at home to keep the dangerous metals out of your water.
What does the TACT study show? Well, in diabetic men, who represent about 1/3 of the 1,708 men in the TACT study, EDTA chelation reduced the risk of subsequent heart attack by 52%, and fatal heart attack by 41%. Taking high dose vitamins and minerals along with the EDTA to rebuild up “good minerals” resulted in the greatest benefit. My read of heart disease risk is that abnormal blood sugar is anything over 86, which differs dramatically from medicine’s range of blood sugar being ok up till 124. But benefit did not accrue to men in the traditional range of diabetes.

WWW.What will work for me. What would I do if I had a heart attack? It is pretty reasonable to suggest that spending 9 months of weekly EDTA visits is worth it. Heart attacks kill. In fact, 50% of us are done in by them.  For now, I’m working on reducing my heart attack risk by getting my blood sugar lower so I turn off the engine that drives heart disease.

Pop Quiz

  1. Chelation does what to water-insoluble metals?                                Answer: encases them in a water-soluble “claw” and allows them to dissolve into blood, and be excreted in the urine.
  2. How much can chelation reduce the risk of a heart attack?             Answer: If you are diabetic, your chance of recurrent heart attack can be cut in half.
  3. Is it worth it?                                                                                             Answer: Let’s see. A simple heart attack with 5 days in the hospital and 6 months of rehab will likely run you around $ 75,000 with a 13% chance of death. Your answer.
  4. How do you do chelation?                                                                     Answer: It takes in IV treatment of about 3-4 hours once a week for about 9-12 months.
  5. Is the science robust for reduction of iron and reduction of heart attack risk? Answer: It appears to go back and forth. In younger years, iron deficiency is the most common nutritional deficiency in America. As we get older and keep absorbing iron, it flips.  The conflicting results may be because of that.

What’s So Dangerous About NightShades?

Deadly nightshade! Dramatic name and well served. It is a very poisonous plant growing in your backyard (at least in mine in Milwaukee). You should know what the berries look like and rid your yard of them before your pets or children chomp on them. Even Shakespeare was well versed about deadly nightshade, as it made Romeo and Juliet, Act IV, Scene 5. The root and vines are equally poisonous, if not more so. Hence, it shouldn’t be a big surprise if other members of the nightshade family are problematic for humans. Well, they are. If you put potato, tomato or eggplant leaves in your salad, you can then arrange for a timely visit to an ER where you will be treated for all sorts of hallucinations if not more ominous symptoms. No kidding. The alkaloids of nightshades kicked off the field of chemistry and anesthesiology, coming out of the traditional healers otherwise known as witches. That’s why your mother told you never to eat any potato that was green. Don’t eat the shoot either. In fact, cut out the eyes of the potato. Whew, pretty dramatic stuff, this nightshade family!
Is the whole nightshade family so awful? Can we not eat tomatoes, eggplant, potatoes, chilis? Please, please make an exception for chilis.
Is there any credible science about the dangers of nightshades? It’s not just the alkaloids that are problematic. They contain unique lectins that set off the immune system and your response to it. What are lectins? They are the proteins the mimic your own proteins in a fashion to poison you and keep you away from eating plants. All animals have evolved in ecosystems in which they became tolerant to the local lectins and indeed consumed with impunity. Humans evolved in Africa and came out of Africa just 90,000 years ago. The nightshades are all New World plants. We’ve hardly had evolutionary time to adapt to their toxins.

How important is it for you to be careful about eating them? That’s the rub. Here we enter into the world of functional medicine and away from the world of evidence-based research. We have many, many practitioners who will tell you they have seen amazing things happen when their clients avoid nightshades. Particularly in the field of autoimmune disease, there is lots of anecdotal evidence that the field of nightshade chemistry is one filled with danger. Then why haven’t we seen objective science?
Answer. We haven’t gotten there yet. There are thousands of different lectins and the day has not yet come that modern medicine would endorse research into that field. It’s still too arcane and appears to work only in small subsets of folks. For example, autoimmune diseases. There appears to be some credible evidence from anecdotal reports that anyone with any sort of autoimmune illness should make their best effort to be off nightshades.

We see that same effect with a more prominent lectin source, wheat. By adding 14 plus 14 new chromosomes from two distinct separate grasses to wheat, we tripled the chromosomes and lectins in wheat resulting in many folks being wheat intolerant. Modern medicine looks at the specific immune disease called celiac disease, present in only 1 of 138 people, and dismisses it outright. You don’t have to look far to find someone who feels much better when they avoid wheat.
What’s a conscientious health seeking person to do about nightshades? Oh heck, have a tomato. Enjoy some eggplant. As long as you don’t have any autoimmune disease. But if you come to me with osteoporosis, or arthritis or coronary artery disease…..don’t say you weren’t warned. Those disease get better when you avoid them. And who doesn’t have them?
www.What will work for me. I’m off potatoes, soy and wheat. But I sure like tomatoes, eggplant and chilis. I weed my fence line of deadly nightshade. I don’t think I have any autoimmune illness. Yet. I’m waiting for more research. It’s pretty thin right now. But I’ve been frankly stunned in my functional medicine practice by the people with autoimmune diseases who have gotten better by avoiding them. Some in just a month. I’ve got a few dedicated folks trying out a lectin free diet with severe coronary artery disease. I’m hopeful.

Pop Quiz

  1. Nightshade plants contain some pretty serious poisons? T or F                  Answer: Even Juliet will tell you yes.
  2. You can safely eat a green potato. T or F                                                         Answer: Please, please, please don’t try.
  3. There is some pretty good proof that lectins are harmful? T or F               Answer: all depends on how you define proof. If you are waiting for a randomized, placebo-controlled trial, you don’t have any proof. If you talk to your neighbor who avoids wheat, just try telling them there is no proof. You will lose a friend and credibility.
  4. Humans are tolerant to what plant-based foods?                                          Answer: Quite a few. Many nuts (not including cashews and peanuts), almost all leafy greens, , olives, avacados……ready Gundry’s book: The Plant Paradox
  5. I free great when I eat a huge green salad with green peppers and tomatoes. Is that so bad? I like the lycopine in the tomatoes for my health.                                         Answer: Come back when you have your first bone density showing osteoporosis. We’ll talk. But until then, I’ll hide behind the concept of conjecture.

Lectin Lesson #3: How Lectins Make you Fat

Reference: Gundry’s The Plant ParadoxAm Jr Physiology,

Did you know that humans lost height and brain case size in the 1000 year transition from hunter gatherer to wheat grower. Gundry quotes this in his book as what has been discovered at archeological sites from those time periods. Civilization had its costs? All so that we could have kings and cities and armies and compete with your neighbors more effectively. Hmm. And we started domesticating pigs and cows, sheep and goats….so we didn’t have to go hunting. Here is Grundry’s conjecture. Wheat and lentils are amazing grains. When you eat them, you gain weight faster and more efficiently to that you can make it through winter more efficiently. Civilization liked wheat, because by putting calories on into storage, those who ate it lasted longer.
Now, extend that to today and see if it’s any different. What do we feed cows before we slaughter them for market – corn and beans? Wild pigs are lean animals. Domesticated pigs have lots of fat (we call if bacon) when fed corn and beans. Those foods make animals fat too. So Gundry’s hypothesis is that humans didn’t choose wheat and lentils to grow because they could be stored, but because you put weight on the most effectively with them. That’s his Plant Paradox. The very plants (wheat and beans) that allowed our ancestors to develop civilization and store calories for the winter were the same plants that hastened our demise from metabolic diseases. Now, that was hidden for the last 9,000 years because we died of measles and tuberculosis and cholera by age 30 anyways, and didn’t see the degenerative effect of inflammation caused by these grains. Grains became the means to civilization not because they could be stored, but because they were the most efficient means to put on weight and make it through winter. They promote more calories into fat deposit than any other food. And then, isn’t it curious that milk from black cows, so called A-1 milk, has lectin qualities to it too in its BMC-7 fragment, and promotes weight gain.
Ok, I get the historical conjecture but is there a coherent biological explanation for how this works? Yes, indeed. It goes as follows. Two key processes are going on.

First, the disruptive effect of the lectin in wheat called WGA. Wheat germ agglutinin. It looks a lot like insulin. Acts like insulin. That’s what lectins are, proteins that mimic mammalian proteins and cause damage by disruption. WGA mimics insulin, badly. Insulin attaches to a cell for a tiny amount of time, then lets go. WGA doesn’t let go. On a fat cell, the message is to take up glucose, forever and ever. That fat cell gets fatter. On a muscle cell, however, the message is to block insulin effect so muscle are starved. Again, WGA doesn’t let go so the real hormone that should be on the receptor can’t dock on its receptor and tell the muscle cell to take up glucose and run with it. Same effect on nerve cells: WGA clamps on and doesn’t let go. Nerve cells are starving. But they send out the message to the organism: “Eat more.”
Even more disturbing isrecent evidence has emerged that lectins can climb up the vagus nerve from the gut to the brain, damaging the substantia nigra, the seat of Parkinson’s disease. Indeed, cut the vagus nerve and the risk of PD drops 40%.
The final argument to support Gundry’s hypothesis might be called the Common Soil Hypothesis – that the mechanisms of metabolism and inflammation are curiously linked. You got fat because your body is at war with itself. And it goes as follows. The lectins set off your “Tiny Little Radars”, your Toll Like Proteins, that reside in your blood vessels and fat cells. They set off cytokines (your body’s fire alarms) calling for white cells to respond to clean up the invading bacteria. Except there are no bacteria. It’s just lectins. But the white cells show up. And your body shifts into war mode. Energy goes to the troops, the white cells. The stay-at-home folks, (Gundry calls them civilians but you think of them as muscle and brain cells) go on war rations and get less. Hence, you become insulin and leptin resistant not because you are overweight, but because your body is inflamed from all the fake lectin signals setting off fire alarms about invading bacteria. Your body is at war, thinking you have been invaded by bacteria, and you are all pumped up and ready to defend. Except that there is nothing to defect. The home folks starve. Fat cells get bigger.

Get it? Stop the war, send the troops home. Weight loss follows automatically. Stop eating lectins. That includes A-1 milk and cheese, nightshade plants, wheat and beans and most of all, genetically modified foods with their genetically inserted extra lectins.

www.What will work for me. This is a paradigm shift type of thinking, but it makes perfect sense. I get it. I just have to figure out how to implement it. And wheat is lurking behind every food in America. And every meat product was raised on lectin foods: corn and soybeans so the lectins in those foods are still there for me to absorb. I have to live with this a while. But I can shift a little. Less beans, less wheat. One step at a time.

Pop Quiz

  1. You are leptin resistant and fat because you eat like a pig? T or F                      Answer: That’s backwards, unless you take eating like a pig to mean you are eating corn and beans, lectin foods. The proper answer is that leptin resistance and fatness comes from the natural shifts your body makes to counter the fake messages caused by eating lectin containing foods. You eat secondarily because your brain cells and muscles are starving, ironically.
  2. Lectins set off inflammation because they activate TLRs? What are TLRs?
    Answer: Toll Like Receptors or “Tiny Little Radars” in Gundry’s clever nomenclature – your natural bar code readers watching what’s in your blood to sort our friend from foe.
  3. You can make great bacon with wild boar? T or F                                                  Answer: Patently false. To make bacon on pigs, you have to feed them corn and beans.
  4. To make bacon on you, the best foods to do that with are?                             Answer: Same as with pigs. Corn, wheat and beans
  5. Ipso facto, to lose weight you need to ?                                                                Answer: create the environment whereby you “stop the war”, turn off inflammation, rid yourself of lectins, eat what nature intended you to eat.

 

 

Birth Control Pills Cause Breast Cancer

 


Birth Control Pills Cause Cancer

References: NEJM Dec 2017New York Times,

That’s it! They do. Birth control pills increase your risk of breast cancer. The issue should be, how much risk are you willing to take for the benefit of birth control. Pregnancy is not a benign condition either. It has risks. Labor and delivery used to be just about the most common cause of death in women, until we got modern medicine, ultrasounds, sterile technique, etc
What’s the data? The study followed 1.6 million Danish women for over 10 years. Their results showed that for every 100,000 women, birth control use increased risk by 13 women a year, from 55 to 68. Over 40 years, that would be 520 extra cases per 100,000 women. That’s 0.5% lifetime risk. Or, a 20% risk increase over baseline. In percent terms it doesn’t sound huge, and indeed, it isn’t compared to other risks. The study was not able to take into account confounding variable like weight, exercise, other disease, breast feeding, alcohol consumption, etc etc. What about IUD’s with tiny amounts of progestins in them? Nope. Still a problem.
What they also found was that lower doses in modern birth control pills still are risky and the use of “low dose estrogen” really doesn’t add much. And, the progestins (Manufactured artificial progesterone) may actually be the main culprit. If you look at the moleculeprogesterone, and compare it to the molecule medroxyprogesterone, you can quickly see that they aren’t the same thing. They have enough overlap in function to fulfill their duty of hormonal manipulation, but then confuse the body by not setting off the normal biological signaling that the proper molecule provides. The mid cycle surge of LH and FSH is suppressed by lowered free hormones, secondary to elevated Sex Hormone Binding Globulin. You don’t ovulate. Presto.
Are other methods of birth control any safer? You have to go through all the complex math of failure rate and risk of pregnancy, and consequences of pregnancy to come to your own decision. At the end of the day, birth control pills and the IUD are extremely effective at preventing pregnancy, but they do have some risk to them. Ok,, you are informed. (And we didn’t go into the risk reduction of ovarian cancer etc that birth control may help – whole other topic.)
Now, can you soften the risk. You bet. When you do get pregnant, consider breast feeding as your “anti-cancer”, “baby’s brain health”, strategy. For every 6 months of breast feeding, your future risk of breast cancer drops some 15-16 percent – with studies rangingfrom 20% to 60% lifetime risk reduction by getting in the habit and sticking with it.

And then there is iodine, 1 mg a day, Vitamin D to a level of 50, exercise, weight control, Vitamin K2, avoid xenoestrogens (BPA) and eat lots of organic vegetables, and you can keep dropping the risk further.

www.What will work for me. This is one of the most common questions I get asked. How safe are birth control pills. It’s a yin and yang. Life has risks and choices. Driving to my office has risks. Texting on the way is dangerous. What I do tell my clients is please, please take a 6 month sabbatical from birth control every 5 years. And if you don’t want any more children, male or female tubes can be clipped.

 

Pop Quiz

  1. Birth control pills cause breast cancer by how much?                                          Answer: 13 extra cases per 100,000 women per year – or .5% higher
  2. What is the risk of pregnancy?                                                Answer: in advanced nations with good prenatal health care, 12/100,000 maternal deaths from pregnancy is what WHO provides.   This low rate occurs where  we do not have a targeted strategy for all pregnant women, it’s higher that other parts of the world where risks are up to 200+/100,000 deaths per year from pregnancy
  3. What is the most effective method to lower my risk of breast cancer?                    Answer: breast feed for at least 6 months with every pregnancy. Try for a year.
  4. What other strategies can I do go lower my breast cancer risk?                               Answer: stay slender, exercise, avoid sugar, iodine 1 mg a day, Vitamin D, K2….
  5. Is the IUD any safer?                                                                                                          Answer: No.

 

 

 

Biotoxin XV: VIP – The Magic Bullet


 Biotoxin XV: VIP The Final Magic Bullet

References: Surviving MoldBiotoxin JourneyInternal Medicine Review,

100%. Did you catch that? Everyone with mold illness, following the 11 step program Shoemaker has put together, will find relief. Well, almost everyone. Some folks who have been sick for years have deeply imbedded patterns and may need to be on VIP for a long time, but nevertheless, Shoemaker has found that his program returns (almost) everyone back to much higher levels of functioning, if not complete cure. The limitations are more on getting to a completely clean environment free from biotoxin after a life time of training their immune system to be “sicker, quicker”. Remember, it’s not quantity that sets off the innate immune system, it’s just the first domino that sets off the storm.
Well, explain what VIP does. What is it first of all. Vasoactive Intestinal Peptide was discovered as being active in the gut, hence its name. But its most profound effects are more likely in the brain.

The sequence of events is as follows. You live in a moldy home, or work in a moldy workplace. The ceiling has black spots below the AC unit upstairs. You breathe in the mycotoxins. (They are TINY: if botulism toxin weighs 150,000 daltons, T-2 toxin weight 466). They set off the “cloud” of cytokines of your innate immune system: the fire alarm. The cytokines attach themselves to the Leptin Receptor in your brain which is the gateway to secrete MSH, VIP and ADP. First, you stop making MSH. With a mucked up VIP receptor, your whole POMC system goes down. You stop making beta-endorphin and you start to hurt all over. Your energy tanks. You gain weight. You are tired.
VIP dropping shortly follows. About 98% of folks with chronic fatigue syndrome have low VIP. It is a regulatory neuropeptide that acts in the hypothalamic suprachiasmatic nucleus. Does that sound like a mouthful? It appears to have a profound effect on Cyclic AMP which is a second tier messenger. But other than that loosy-goosey explanation, we haven’t a clue how it really works. And it just doesn’t work if you skip any steps in the 11 step program. But if you have done the other 11 steps, it becomes a secret super weapon. It works in minutes.

The sorts of things you can measure are almost immediate improvement in the pulmonary artery pressure. That means blood is flowing much faster, immediately. Breathing is easier. “Asthma” suddenly feels ok. That means energy perks up, right away. In two hours your fizz is back. In two days you feel like you were never sick. For those folks with joint stiffness, 10 minutes and you are feeling more limber. This is a real magic wand.

The protocol is to take it as a nose spray 4 times a day for 30 days; then twice a day for 30 days; then daily for 30 days; then off 30 for days.

Unless: you have any of the following: ERMI > 2 at home/work/school, your VCS (Visual Contrast test) still positive, still have MARCoNS in your nose, MMP9, PAI-1, leptin still high, Untreated C3a, C4a, TGF beta-1 still hanging around.

This is really cool. We have a final step that fixes things that is measurable, repeatable, explainable. I have met one person who flunked VIP, albeit they did feel a little better.

www.what will work for me. I’m eager to get experience of using it. Again, it will be a new modality in this town so getting a pharmacy to make it right might be a challenge. Getting insurance to pay for it. Well, dream on. But there are work-arounds for all those things. In the meantime, I’m still working on my own basement. My ERMI was 4 and I’m determined to get it down. When I see someone with a -6 ERMI, I’m jealous. They lived on the 16th floor of a pristine, new condo building. Lucky devils.

 

Pop Quiz

 

  1. Where was VIP discovered?                                                       Answer: as a regulatory peptide in the gut, hence the name, Vasoactive Intestinal Peptide.
  2. Where else does it work?                                                           Answer: very definitely in the brain – in the suprachiasmatic nucleus, to be exact – and many others.
  3. What does it do?                                                                          Answer: We haven’t a clue. It has effects on a secondary messenger inside cells called c-AMP but other than that, we are clueless. It just fixes everything like a magic wand.
  4. What makes it not work?                                                            Answer: anything in the previous 11 steps that weren’t fixed first. Still living in a toxic environment with an ERMI score over 2, still having MARCONs in the nose, still having elevated cytokines, etc etc.
  5. How quickly does it work?                                                           Answer: Minutes. And can be tapered over 3-6 months to off, provided the person doesn’t go back into their dangerous place.

 

Biotoxin XIV: Fixing TGF-beta 1

 

Biotoxin XIV: Fixing TGF-Beta1

References: Shoemaker ProtocolScienceWikipediaSci Rep 2017,

We are almost at the end of our Biotoxin Treatment Pathway. Fixing TGF-beta 1 is next to last. If your level is over 2380, you need to fix it. And fix it you can. What is it that TGF-beta 1 does? It’s a member of superfamily of cytokines in that it has myriad functions. It plays a key roll in cellular differentiation, proliferation, and finally apoptosis. Many cells secrete it and respond to it, so our understanding of it is just getting started. We do see it act badly in Marfan’s syndrome where folks are super stretchy and bendy and have a “wingspan” greater than their height. They often die from burst aortic aneurysms, caused by too much TGF-beta 1. In fact, someone whose wingspan is greater than their height is very likely to have an elevated TGFb1. Hmmm. Might you measure yours? If you have an autoimmune disease, know your wingspan, and your TGFb1, as fixing your mold illness may revert your BT illness. Cool, huh!
Levels of 5000 and below usually aren’t too sick but over 10,000 and you are almost certain to have some identifiable effect. Lung, joint, brain are common victims. For example, in the brain we know that glial cells put out Glial Fibrillatory Acidic Protein, that inhibits cell growth and axonal connections. In lungs we suspect that at many as 50% of adults developing new asthma are doing so from biotoxin illness with ‘TGF-beta 1 playing a leading roll.

TGF beta 1 drives the development of imbalance between T-regulatory CD4+CD25++ cells and TH-17 cells. This might be at the heart of autoimmunity. T-regulatory cells help prevent autoimmunity – the body attacking itself. In some with biotoxin illness, T-regulatory cells are improperly changed into pathogenic effector T-cells by TH-17 cells. The next effect is an endless positive feedback look driving more TGF beta 1. We can now measure CD4+CD25++ and CD4+CD25++127lo/- cells as one method of getting to the heart of this imbalance. Can you imagine if this works out to have a major impact on ALL autoimmune disease. That would be so amazing!

How do you fix it? Actually, it’s easy….well, sort of. Cozaar, or Losartan, yes – a high blood pressure mediation lowers TGFbeta 1. If it is above 2380, and particularly if T-regulatory CD4+CD25++ combo cell levels are less than 18, you need to be on Losartan. 25 mg twice a day will do most adults, but if blood pressure doesn’t drop too much, 50 mg a day will push it even faster. For how long? Until you are better. Not years, weeks. Maybe months. Provided you are out of the biotoxin environment and not being reignited with new inflammation. For those whose blood pressure is too low, VIP spray also works. (Next week).

What is it that Losartan does? Remember, you asked: here goes: “EXP3179, but not losartan and EXP3174, dose-dependently inhibited (P<0.05) phorbol myristate acetate and insulin-stimulated NADPH oxidase activity. EXP3179 also inhibited phorbol myristate acetate-induced NADPH oxidase in endothelial cells. In addition, EXP3179 inhibited (P<0.05) both phorbol myristate acetate-stimulated p47phox translocation from cytosol to membranes and protein kinase C activity.” Did you get that? I didn’t either till I read it three times. Remember, EXP3179 does it, not Losartan. But it does lower TGF-beta 1. Aren’t you relieved! Stupid little high blood pressure medicine, works wonders on TGFb1.

WWW.What will work for me. I’m seeing tons of folks with CIRS and mold illness with TGFb1 over 10,000. My highest has been 28,000 something and that person answered 29 symptoms on Shoemaker’s symptom list. Mostly they said their brain just didn’t work. Can you imagine the wonder I feel to see folks getting better from a mystery illness that heretofore went not only unrecognized, but blamed on the victim?  It’s like a Christmas present.

 

Pop Quiz:

1.     TGFb1 is ….?                                                                    Answer: a peptide cytokine that has regulatory properties for cell growth and differential, and eventually cell death. It plays a key role in facilitating autoimmune disease.

2.     It needs treatment to lower it when…?                       Answer If you feel sick and have levels over 2380,

3.     The best way to lower it is with a drug called…..?     Answer: Losartan

4.     How long do you have to treat for?                             Answer: until better with normal TGFb1, which might be a couple of weeks or months. Or VIP

5.     If you are “double jointed” and can bend your fingers back to your wrist or scratch the middle of our back easily, you might first want to measure what?                   Answer: Your wingspan, then your TGFb1.

 

 

 

Biotoxin XII: Cleaning up C3a

References: Surviving Mold, Mold Warriors, p 396Jr of Immunology,

Ever heard of C3a? Bet you hadn’t. Ever heard of statins? Sure. That’s where statins work. And C3a is the heart of biotoxin illness. It is the nexus of the complement system. The complement system is the cascade of inflammation that fires off when your body sees and recognizes an outside invader. We have made the analogy of biotoxin setting off the 911 alarm system in your community with sirens blaring everywhere. C3a is the volume of the siren.

You can look at a diagram of the C3a activation system. and you see that the production of C3a is the first summary action. And uniquely, it plays in role in starting the inflammatory process, and then in modulating and reigning it in. Shoemaker has discovered that C3a is like the gift that keeps on giving in mold illness. When folks get sick, it’s C3a and C4a that go up right away. In Lyme disease, C3a is a unique marker for early Lyme and can skyrocket with two days of infected Lyme bite. The same happens with acute mold exposure. C3a rises as soon as within 4 hours of exposure to mold. In folks with the genetic HLA biotype for susceptibility to Lyme, the C3a doesn’t go back to normal with the proper antibiotics. In folks with a normal HLA genotype, their C3a goes back to normal. That explains the Lyme riddle of why some folks never get better with continued antibiotic.

What’s going on in mold with high C3a? The complement system continues to be activated. Low grade inflammation of the innate (lizard) system keeps happening and the involved person keeps feeling ill. What ever organ appears to be affected continues to be affected. For those with plaque developing in their brain, they keep developing plaque. For those getting asthma, they keep getting worse. For those getting coronary artery disease, they keep getting worse. C3a is the attack dog of the innate immune system, and it continues to rot you out from the inside.

Now, along comes a unique cure. Guess what lowers C3a and puts it to bed? Guess what resolves the inflammation and cures C3a, provided the mold exposure is gone? A high dose statin. For a month. Yes. A statin. Imagine, is this why statins work? You can search the internet and see lots of odd links, but Shoemaker has seen the clinical evidence of coronary artery disease and “cholesterol” normalizing with C3a normalizing. Now, you need to start CoQ10 at least a week before you start the statin, and push whatever statin you use to its upper limit, and then watch the C3a fall. And with the MMP9 coming down, and the PAI-1 coming to normal mean the illness was cured.

Can you imagine the scope of biotoxin illness if everyone developing coronary artery disease had their HLA typing and their C3a measured. This topic might have broader implications than anyone has imagined yes.

WWW.What will work for me. Well. Measuring C3a is turning out to be quite a challenge. I haven’t figured it out yet in Milwaukee. None of my labs have done it right, so we are in that stage of trying to navigate this journey. Once we can get the wheels greased for the lab evaluation, I have lots of folks pent up waiting to get better. But they only get better when their mold illness is fixed, and that starts with their homes and their workplaces. I got Sporocidin today and the sprayer is coming. I want my basement to smell pristine when I’m done. Sporocidin is the cleaning agent you want to use if you have a “moldy” smelling basement.

 

Pop Quiz

1.      C3a is the common instigating cytokine in the innate immune system? T or F                  Answer: That is about as accurate as you can be

2.      C3a both activates and modulates the innate immune response. T or F                           Answer. Again. Just about right.

3.     In acute mold illness, C3a rises very rapidly? T or F                                                                Answer: Bingo, you can prove it with reexposure.

4.      In Lyme Disease with the dreaded Lyme HLA phenotype, you get better in just two weeks. T or F       Answer: This was my dummy question. If you got this wrong, you didn’t read the column and skipped to the pop quiz. False.

5.     And you can cure high C3a, and in fact MUST cure high C3a, with what?                           Answer: High dose statins for a month, after meticulous removal from exposure.