Category Archives: 19. Autoimmune Disease

Low Histamine Diet

Low Histamine Diet

References: AJCNInter J of ImmunopathFactvfitness.comMarion Institute,

Ok, the source I started with was a bit odd. She knocked on our office door after we were closed and had the front lights turned off. She was a teacher with CIRS (Chronic Inflammatory Response Syndrome) who had been flying to California to see a CIRS doctor and wanted to know if we could pick up her care. When I asked her what she did that made the biggest difference, she said, “When I followed a histamine-free diet, I got better.” Histamine Free! What’s that?
Histamine is easily made in your body. It is a neurotransmitter used in your brain. It is widely present in your gut but most of it shows up in mast cells that set off allergic reactions. You block those reactions when you take an antihistamine. When you get hives, your immune system is blasting off, releasing histamine all over the place. Once it has been released, it is meant to be degraded promptly by degradation enzymes, notable Diamine Oxidase.
Here is this week’s study. If you take 14 folks who present to an allergy clinic but have negative skin testing for allergies, don’t have celiac disease but get better when placed on a low histamine diet and test them Diamine Oxidase deficiency, you find something very interesting. Those folks have a diamine oxidase activity of 7, whereas 34 normal folks without the symptoms have levels of 39. That’s a big difference. Diamine oxidase deficiency is a real entity. It’s a “condition” that leads you to being vulnerable to too much histamine.

Here is the rub. In CIRS, your innate immune system (the primitive, reactive, non-specific part) fires off constantly and without proper supervision and control by the adaptive system (precise, targeted, controlled). And it sets off histamine-like crazy. Some folks have all sorts of reactions to histamine with the least provocation. This is often matched with very high C4a, and you can see it by taking a blunt object to their backs and drawing a tic-tac-toe board – you make wheals from all the histamine release. That’s called dermatographism.
Where do you get histamine from in your diet? Fermented food is the most common source. Anything fermented. Wine, sauerkraut, eggplant, spinach, avocado, any old stale food out of the fridge, the list is very long. In fact, there is a risk of malnutrition if you take the list too seriously for too long. The goal is to cut back dramatically on any food that may be setting off symptoms and then sit tight for a few weeks. Fresh food, prepared at home with minimum spices and eaten immediately is the first step to cure. For example, fish you catch and eat promptly is ok but once it’s in the grocery store, the tiny bit of spoilage involved in shipping, packaging, and selling is enough to generate sufficient histamine to get you sick. Normal folks with enough DO activity can tolerate it. It has to be a journey of self-discovery.

What is the most common clinical symptom? Gastrointestinal distress is probably the biggest problem. Cramps and diarrhea 15 minutes after eating leftovers out of the fridge would be a pretty common clue. Reflux, urinary frequency, itching, hives, nausea and vomiting and just about everything else coming on after eating all point to the syndrome. Symptoms are so diverse, it’s easy to not consider because no two people are quite alike.

We don’t have a test for it, yet. The Diamine Oxidase test isn’t commercially available. But you can draw on your back. C4a is hard to get an accurate result but worth the try.

WWW.what will work for me. I’m trying to eat fresh vegetables as much as possible anyways. But fermented foods have many fine qualities to them. The probiotic effect of fermentation is profound and in most circumstances beneficial. And what’s not to like about promptly prepared free meat. I must say, when I was fishing last month, the fresh fish was wonderful. But I don’t have CIRS.

 

Pop Quiz

 

  1. Where does histamine come from?                                             Answer: Fermented and stale foods and some particular foods like alcohol, soy, chickpeas, peanuts, cashews…..
  2. Where is histamine concentrated in your body?                       Answer: in MAST cells in your gut and skin.
  3. Eating high histamine foods will do what?                                  Answer: Frequently set off all sorts of gut issues like cramping and diarrhea, hives, asthma….all histamine chemical effects
  4. What’s the histame free diet? Answer: Simple:                          Avoiding those foods, discovered by eating freshly made foods not on the list, and seeing how you react.
  5. What’s the cure?                                                                              Answer: Go upstream to the cause. It’s frequently CIRS brought on by mold sensitivity in a person with a vulnerable HLA type. Fix the mold and clean them up with Cholestyramine and you are on the way.

 

 

The Alkaline Diet IS the Keto Diet of Choice

The Alkaline Diet IS the Keto Diet of Choice

References: Pure WowDr AxeBook of DanielSaddleback ChurchU of BCJournal of Nutrition,

There has been a recent flurry of articles in the media about the alkaline diet with a few “expert dieticians” poo-pooing it and suggesting you should just follow the Mediterranean diet instead. What’s the confusion for? Let me straighten this out for your so that you get the gist of it.

First of all, the alkaline diet isn’t anything new. The Book of Daniel in the Bible talks about it with the first recorded RCT (Randomized, Placebo-Controlled) experiment in history. That was from 3,000 years ago. Daniel and his fellow observant Jews ate vegetables, (alkaline) and the members of Nebuchadnezzar’s court ate meat. Daniel’s crowd did better. Even got published in a reputable journal that is still read avidly (Bible). And as best I can tell, is still helping people lose weight.
What is the Daniel Diet? Or the Alkaline Diet? Vegetables. Vegetables are filled with potassium and magnesium salts which participate in making your urine pH positive, or greater than seven, which is neutral. Your blood doesn’t change its pH in any measurable fashion, but just that tiny amount enough to switch buffers. You have a complex system of buffers in your blood that helps balance your pH very precisely and exquisitely. You breathe every breath as part of that balance, so it is virtually impossible to measure the changes on a second by second basis in your blood. But you can see it in blood samples of folks eating an alkaline diet. Their red cells are coated with alkaline salts and flow separately from one another. I’ve seen it with my own eyes. And your kidneys just pump out the acid or alkali as fast as they can. In meat/animal based America, everyone’s urinary pH is quite low, around 5.5 We have kidney stones, osteoporosis, vascular disease, cancer all as possible resulting outcomes. Very very few of us eat an alkaline diet. The guy who invented, Robert Young, got way ahead of the curve and ended up in prison for practicing medicine without a license. That doesn’t mean he wasn’t right, just not licensed.

Why is this so valuable? For most of mammalian/hominid history, we were vegans and our kidneys (which control your acid-base flow, and eliminate acid or base) were designed to rid you of alkaline salts, most notably potassium or magnesium. That’s because we ate massive amounts of alkaline foods. All hominids except humans eat mostly raw plants. Gorillas eat 15 pounds of leaves a day. Orangutans, 20 pounds of green leaves (except in fruit season). Their urine is alkaline. Your kidneys can still excrete massive amounts of potassium and sodium. But not acid. With acid, we struggle a little. Humans living a hunter-gatherer lifestyle today (Hazda in Africa) still eat mostly alkaline foods. They know some 250 edible plants in the forest, which they eat. But our brains require more calories to support their energy needs, and animals became more important. About 5 million years ago, we started adding animal to our diet. We like animal. We thrived with more of it.
But animal-based foods have more sulfur salts in them, which are acid. The more animal we eat, the more acid we become. That includes cheese, milk, eggs, fish, and yes, meat. Cheese is the most acid of all because it also has lots of salt added to it. And grains are also acidic, altho a little less so.
All that acid has to flow through you, in your blood. Your blood pH can’t change and doesn’t. But your buffers do. The balance of buffers is read with exquisite sensitivity by your bone cells and every membrane in your body. You start giving up calcium carbonate to balance the buffers, which is the slippery slope of beginning osteoporosis.
What about fat? Fat is neutral. Neither acid or base. Just pH neutral. It has some baggage though. Saturated fat, when from animals, comes with animal protein, which is acidic. Unsaturated fat, from seeds, is high in omega six fats which start inflammation.
And here is the kicker. Remember, gorillas digest green leaves into short chain fatty acids. So do we. A diet rich in green vegetables is a high-fat diet. Then add olive oil and you are even better off. A green salad diet smothered with olive oil is an alkaline, healthy, Daniel diet. Get that? A vegetable-based diet is a keto diet, provided you avoid the roots and the grains. Eating spinach is actually getting fat. Keto redux. You lose weight. You have less cancer. You have less heart disease. You have fewer autoimmune diseases. Your body can heal.
That leaves you with an alkaline diet rich in leafy, green vegetables with lots of safe fats as the diet of choice. The alkaline diet is the purest form of the keto diet. The only question is whether you can be so pure. Ah, there is the rub!

www.What Will Work for me. I’m shifting my animal proportions to more vegetable. Instead of two eggs for breakfast, one egg in spinach. For lunch on the plane, I took an avocado, cut in half at home. Made a great lunch. And I’m fascinated by the Fast Mimicking diet. It’s vegan with nut oils. It’s a keto diet too. In time, we will let Robert Young out of prison and say sorry. (There’s a lot of Robert Young’s work that is pure quackery, but the alkaline part is not.)

 

Pop Quiz

  1. A diet of mostly vegetables, olive oil and a tiny bit of fish is currently called? Answer: The Mediterranean Diet (whatever that is, as all the countries around the Mediterranean have different cuisines, except for their abundant use of olive oil and vegetables)
  2. To be on an alkaline diet, you have to do what? Answer: Eat enough vegetables and little enough meat and cheese to shift your urinary pH to something greater than 7. Very hard to do. Almost no meat.
  3. How does your body balance acid flowing through the system to be excreted by your kidneys? Answer: by a system of buffers, by giving up a tiny bit of Calcium Carbonate from your bones, and by breathing a little more deeply.
  4. The first advocate for the alkaline diet has been elevated to hero status in the annals of medicine. T or F Answer: Are you kidding, he is in prison for reaching way beyond the core truth of his alkaline diet idea.
  5. What is the most recent evidence-based diet, beyond the Mediterranean Diet, that is taking the literature by storm? Answer: The Fast Mimicking Diet that adds fasting to the mix

 

 

 

What’s So Dangerous About NightShades?

Deadly nightshade! Dramatic name and well served. It is a very poisonous plant growing in your backyard (at least in mine in Milwaukee). You should know what the berries look like and rid your yard of them before your pets or children chomp on them. Even Shakespeare was well versed about deadly nightshade, as it made Romeo and Juliet, Act IV, Scene 5. The root and vines are equally poisonous, if not more so. Hence, it shouldn’t be a big surprise if other members of the nightshade family are problematic for humans. Well, they are. If you put potato, tomato or eggplant leaves in your salad, you can then arrange for a timely visit to an ER where you will be treated for all sorts of hallucinations if not more ominous symptoms. No kidding. The alkaloids of nightshades kicked off the field of chemistry and anesthesiology, coming out of the traditional healers otherwise known as witches. That’s why your mother told you never to eat any potato that was green. Don’t eat the shoot either. In fact, cut out the eyes of the potato. Whew, pretty dramatic stuff, this nightshade family!
Is the whole nightshade family so awful? Can we not eat tomatoes, eggplant, potatoes, chilis? Please, please make an exception for chilis.
Is there any credible science about the dangers of nightshades? It’s not just the alkaloids that are problematic. They contain unique lectins that set off the immune system and your response to it. What are lectins? They are the proteins the mimic your own proteins in a fashion to poison you and keep you away from eating plants. All animals have evolved in ecosystems in which they became tolerant to the local lectins and indeed consumed with impunity. Humans evolved in Africa and came out of Africa just 90,000 years ago. The nightshades are all New World plants. We’ve hardly had evolutionary time to adapt to their toxins.

How important is it for you to be careful about eating them? That’s the rub. Here we enter into the world of functional medicine and away from the world of evidence-based research. We have many, many practitioners who will tell you they have seen amazing things happen when their clients avoid nightshades. Particularly in the field of autoimmune disease, there is lots of anecdotal evidence that the field of nightshade chemistry is one filled with danger. Then why haven’t we seen objective science?
Answer. We haven’t gotten there yet. There are thousands of different lectins and the day has not yet come that modern medicine would endorse research into that field. It’s still too arcane and appears to work only in small subsets of folks. For example, autoimmune diseases. There appears to be some credible evidence from anecdotal reports that anyone with any sort of autoimmune illness should make their best effort to be off nightshades.

We see that same effect with a more prominent lectin source, wheat. By adding 14 plus 14 new chromosomes from two distinct separate grasses to wheat, we tripled the chromosomes and lectins in wheat resulting in many folks being wheat intolerant. Modern medicine looks at the specific immune disease called celiac disease, present in only 1 of 138 people, and dismisses it outright. You don’t have to look far to find someone who feels much better when they avoid wheat.
What’s a conscientious health seeking person to do about nightshades? Oh heck, have a tomato. Enjoy some eggplant. As long as you don’t have any autoimmune disease. But if you come to me with osteoporosis, or arthritis or coronary artery disease…..don’t say you weren’t warned. Those disease get better when you avoid them. And who doesn’t have them?
www.What will work for me. I’m off potatoes, soy and wheat. But I sure like tomatoes, eggplant and chilis. I weed my fence line of deadly nightshade. I don’t think I have any autoimmune illness. Yet. I’m waiting for more research. It’s pretty thin right now. But I’ve been frankly stunned in my functional medicine practice by the people with autoimmune diseases who have gotten better by avoiding them. Some in just a month. I’ve got a few dedicated folks trying out a lectin free diet with severe coronary artery disease. I’m hopeful.

Pop Quiz

  1. Nightshade plants contain some pretty serious poisons? T or F                  Answer: Even Juliet will tell you yes.
  2. You can safely eat a green potato. T or F                                                         Answer: Please, please, please don’t try.
  3. There is some pretty good proof that lectins are harmful? T or F               Answer: all depends on how you define proof. If you are waiting for a randomized, placebo-controlled trial, you don’t have any proof. If you talk to your neighbor who avoids wheat, just try telling them there is no proof. You will lose a friend and credibility.
  4. Humans are tolerant to what plant-based foods?                                          Answer: Quite a few. Many nuts (not including cashews and peanuts), almost all leafy greens, , olives, avacados……ready Gundry’s book: The Plant Paradox
  5. I free great when I eat a huge green salad with green peppers and tomatoes. Is that so bad? I like the lycopine in the tomatoes for my health.                                         Answer: Come back when you have your first bone density showing osteoporosis. We’ll talk. But until then, I’ll hide behind the concept of conjecture.

Simple Bicarb May Help Autoimmune Diseases

Simple Bicarb May Help Autoimmune Diseases

References: J. Immunology,

Fascinating! When you drink simple bicarb (Yes, Arm and Hammer cheap stuff) you send several messages in your body we didn’t know about. The first is to make more acid the next time around to help digest the next meal. And the second is for mesothelial cells on the spleen to signal to all the immune cells inside the spleen to chill out. “Don’t make an immune response.”
What are mesothelial cells? They are the lining of your guts, your abdominal cavity. Every organ is lined with them on the outside. We thought they were there primarily so that the organs can slide over each other with no friction. That feature allows you to move without things being caught up inside. But the surface of mesothelial cells have an interesting feature. They have tiny little fingers called microvilli that signal messages internally to the organ beneath about invasion or intrusion. Mount an immune response, or not!

Here is what this study found. Drinking bicarb for a couple of weeks changed the internal splenic macrophages from a population of mostly M1 macrophages (turn on inflammation) to M2 macrophages (Turn off inflammation). Considering that the spleen is the main repository for immune cells waiting for dispatch, that effect is pretty meaningful. What is unique is that the message is transmitted through the wall of the stomach, via these mesothelial cells, into the wall of the spleen via its mesothelial cells with a result of lowered inflammatory response. Macrophages are typically known for gobbling up garbage from old, dead, dysfunctional tissue and they are some of the first to arrive on the scene in inflammation to clean up the “battlefield” of dead and dying tissue. Autoimmune diseases are thought to be a whole scene of dysfunctional, overreactive inflammation and activation of macrophages. Turning them off is a key thing.

It’s not just macrophages but also Treg cells that get altered with bicarb. Treg cells are supposed to be regulators of immune response and help dial it down. This dialing down is helpful at controlling weird autoimmune reactivity too. And this also occurs because of the messages from those mesothelial cells putting out acetylcholine, acting almost like nerve cells even though they are lining cells of organs. Strange cross over reactivity.

Where does alkaline predilection come from? Through most of human history, we were vegans, starting to eat meat just a few million years ago when our brains started getting bigger and needed animal energy to power them. Animal protein has lots of sulfur in it making for a biological ash of acid when all is digested and done. Plant sourced food ends up making alkali with all the magnesium and potassium salts. Most of our biological processes evolved in an alkaline environment. The range and intricacy of our immune function is all founded on an alkaline milieux. Animal food, hence acid, is new. You can measure this in yourself. Eat a diet of pure green vegetables for a week and measure your urinary pH. It will be above 7. Have some cheese and steak and watch your urine pH plummet to 5.5. Every drug store carries pH sticks you can measure on your own.  Ten servings of vegetables is about 1 tsp of bicarb.  Simple

WWW.what will work for me. Considering how much of the Longevity Diet by Longo is based on vegetables, we may find that part of its power comes from shifting the immune response from inflammatory, to anti-inflammatory. Here is a clue that we are probably all better served with more vegetables. Their alkaline salts help you out. So, I ordered doubled vegetables for dinner last night instead of a potato. Then the blooming onion hors d’oeuvres did me in. I’m not sure it really counts as a vegetable.

 

Pop Quiz

  1. Your internal organs are lined by what type of cells?                         Answer: Mesothelial cells
  2. Mesothelial cells are lined by what cellular feature?                          Answer: Tiny fingers called “microvilli”.
  3. This article says these cells do what?                                                    Answer:  The communicate across organs and down regulate inflammatory immune response
  4. What class of diseases is this particularly useful?                               Answer:  Autoimmune in which there appears to be unregulated inflammation.
  5. You can get the same effect of a tsp of bicarb by eating what type of food?                 Answer:  LOTS of vegetables, green in particular.  Roots won’t do it as well, if at all.

Fast Mimicking Diet 3: The Fasting Part

Fast Mimicking Diet 3 The Fast Mimicking

References: Longo: The Longevity Diet, [Science], Science DirectCellCell Metabolism,

I like to eat. I get hungry. What is it about fasting that makes me do better? Let’s review. Valter Longo found that there were two processes in yeast (very primitive organism) and mice (sophisticated mammalian organism) that respond in the same way. RAS and TOR. Those are the two pathways that appear to accelerate aging. Sugar turns on RAS-PKA and extra protein turns on TOR-6SK Growth Hormone Pathway. If you can down regulate the RAS pathway, you increase the rate of clearing out old, dead, malfunctioning tissues and organelles. That’s called autophagy. TOR is an internal monitor of nutrient density and controller of cell growth. Can’t grow if you don’t have enough food. Dial TOR down and cells stop dividing and go into hunker down mode. Alter those two pathways and presto, chango, you have gotten to the root cause of aging in humans. That discovery, that these two pathways are fundamental to all life on this planet, starting with yeast and moving all the way up to humans, is Longo’s key contribution to modern understanding of aging.
Fasting turns both those pathways in the right direction. It takes about 24 hours to use up the glucose in your liver, stored as glycogen. The human body then switches to burning fat from stores in fat cells. The brain and body utilize ketone bodies in a process termed ketolysis, in which acetoacetic acid and 3-β-hydroxybutyrate are converted into acetoacetyl-CoA and then acetyl-CoA. In yeast, glucose, acetic acid and ethanol, but not glycerol which is also generated during fasting from the breakdown of fats, accelerate aging. Not glycerol. Did you get that? There is one carbon source that doesn’t turn on the nutrient recognition pathway. Glycerol is the 3 carbon fragment that holds fats together in tri-“glycerides”.

Fasting for 3 or more days in humans causes a 30% decrease in circulating insulin and glucose, as well as a reduced level of insulin-like growth factor 1 (IGF-1), the major growth factor in mammals, which together with insulin is associated with accelerated aging and cancer. Fasting for five days results in a 60% decrease in IGF-1and a 5-fold or higher increase in one of the main IGF-1-inhibiting proteins: IGFBP1. This effect on IGF-1is mostly due to protein restriction, and particularly to the restriction of essential amino acids, but is also supported by calorie restriction since the decrease in insulin levels during fasting promotes reduction in IGF-1. In humans, chronic fasting does not lead to a decrease in IGF-1 unless combined with protein restriction.
Did you get all that? It’s the protein restriction that matters. Five days appears to be the time period in which maximum reduction of cancer growth factors and insulin occurs. You can trick the system with some glycerol which doesn’t register as a sensed nutrient. And we have some markers of metabolism to show your success. 5 days. Reduced protein, animal in particular. Cut the calories down to low enough to turn on and maintain ketogenesis. Sounds like about 800 a day will work. The goal isn’t to lose weight but to turn on anti-aging genes.

WWW. What will work for me. Well, I’ve finished one cycle for myself and lost 6 pounds while doing it and another two pounds over the subsequent three weeks. Not bad. I’m going to do two more cycles and then repeat my own lab tests. Glycerol makes an interesting little sport drink. It’s slightly sweet and with a bit of flavor added from a tea, it’s not so bad. I’ve bought some hibiscus tea.

Pop Quiz

 

  1. What nutrient can you consume that is slightly sweet and doesn’t trigger calorie sensing? Answer: Glycerol
  2. What amino acid turns on aging, and absence turns off aging? Answer: leucine in particular.
  3. Five day fasting results in a 60% decrease in what? Answer: IGF-1 or our Growth Hormone surrogate marker.
  4. Along with that, you get up to a 5 fold INCREASE in what IGF-1 inhibitor? Answer: IGFBP1.
  5. What lab tests might you want to know if you were getting success in your fasting methods? Answer: Glucose, insulin, IGF-1 and IGFBP-1

 

Lectin Lesson 4: What Elephants Having Heart Attacks Teaches Us About Cancer

References: Steven Gundry’s The Plant Paradox, CirculationScience Direct,Front Oncol., Glycobiology,

Ok, caught your attention? Elephants having heart attacks? Yes, it’s true. Now, when elephants live in their natural habitat that has sufficient tree and brush forage, they never get a heart attack. In the last couple of hundred years they have lost habitat and been driven to eating grasses. Elephants don’t eat grass when they have natural leaf habitat – they eat leaves. When they eat grass they develop coronary disease, just like us. Why does that happen?
We share an odd and uncommon sugar with elephants. It is called Neu5ac. I’ll call it N-A. It’s a member of the sialic acid family of sugars. We share it with shellfish, chickens and elephants. When we diverged from chimps 8 million years ago, we started making Neu5ac (N-A). Chimps make Neu5gc (N-G). As do every other mammal including the ones we eat like cows, goats, sheep, pigs. This sugar, N-A) is like a signal in our gut cells and our arteries. And grain based lectins bind avidly to it. WGA, the lectin in the wheat germ, binds avidly to it. Avidly. But grain lectins don’t bind to N-G.
Here’s where the link happens. When we eat red meat containing Neu5gc – N-G, your immune system recognizes it as foreign and makes antibodies to it. Those antibodies then turn around and attack your own Neu5ac (N-A) receptors. You get antibodies on your blood vessel walls. You call in white cells. Coronary artery disease is off and running. When elephants eat grasses, they get the same cross reactivity. Something about having grass (wheat) based lectins that attach to Neu5ac and eating the Neu5gc form of the sugars makes for that autoimmune attack.
Now, swing over to cancer. Human cancers have a lot of the Neu5gc protein in them. They put it on their surface as a means of hiding from our immune system. Wait a minute! We don’t make it. Human cells cannot make Neu5gc. Right, we don’t. Then how does the cancer get it? From our eating it in red meat. That may be the link between our eating excessive red meat, and having more cancer. The more red meat you eat, the more N-G you get to supply cancer cells with camouflage. Did you notice that chicken and shell fish don’t have N-G. They have N-A, just like humans and elephants. When you eat chicken and shell fish, you have less risk of heart disease and cancer.

The mechanism that is driving both of these phenomenon is the presence of these sialic acid sugars called Neu5ac versus Neu5gc. Their subtle name difference is the whole universe of immune recognition. That simple little alteration is all it takes for your immune system to go the wrong direction and start a process that leads to the slippery slope of coronary artery disease, or cancer.

WWW. What will work for me. This is a smoking gun. It tells us the clear mechanism by which this elegant, delicate signaling system shifts our immune reaction against either ourselves or against our own immune vessels. Or cancer. It’s simple. We get B12 from red meat. We have to have it. A tiny bit. I mean tiny bit. Seems like we need to start thinking about how we can change the balance of calories. If ketogenic eating is important for our brains, then it has to be with healthy fats, not meat. And it all comes down to those magnificent gentle animals, elephants.

Pop Quiz

 

  1. Elephants were designed to eat grasses? T or F                                               Answer: False Leaves
  2. When elephants eat grasses they develop what illness in common with humans?           Answer: Coronary artery disease
  3. The key link in the immune response is a lectin binding sugar called?                             Answer: Neu5ac – a member of the sialic acid family of sugars
  4. The principal damaging lectin in wheat, WGA binds to which of the two sialic acids – Neu5gc or Neu5ac?                                                                                                                                Answer: N-A not N-G
  5. Human cancer cells get their camouflage from?                                        Answer:     Red meat Neu5ga.

 

 

Lectin Lesson 2: How Lectins Cause Damage with Inflammation

References: American Heart Sci Meetings,Jr, ImmunologyResearchgateWikipediaAthersclerosis,

Just what is going on with lectins? What’s the big deal? Do they really cause trouble?

To understand those questions, you have to understand the complement system in your body. This is not about saying a nice thing to you about your hair, or your necklace, this is about your basic lizard brain immune system, your innate immune system. Your innate immune system is the first to respond to threats with non-specific responses. If you think of a series of dominoes, each of which knocks over two more, the innate immune system is the means by which your body kicks back immediately against external threats and makes immediate reactions that happens quickly in response to “invasion”. A cascade of chemicals create tags to place on the invader to tell a white cell to eat that particular invader, (Opsonization is the fancy term) or punches a hole in the wall of the invader with donut shaped proteins so the invader leaks its guts out. You can imagine, this has to be carefully controlled as if it balloons out of control, you get the shaft and your own cells get damaged. The adaptive system, layer two of your immune response, takes longer to gear up and make specific antibodies shaped precisely to attack the invader, or specific white cells armed with bar code readers to find and destroy the invader. Doing all that takes time. In the short term, the complement system is it.
There are several pathways into the complement system. The classical pathway, the alternative pathway and the LECTIN PATHWAY. Did you get that? The lectin pathway is one of the ways you set off your innate immune system. To understand this pathway you have to be able to read the following sentences without pausing: This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) to microbial surface oligosaccharides and acetylated residues, respectively. Upon binding to target molecules, MBL, CL-K1, and ficolins form complexes with MBL-associated serine proteases 1 and 2 (MASP-1 and MASP-2), which cleave C4 and C2 forming the C3 convertase (C4b2a). If you drill down into that, it simplifies to the sugar mannose that is part of many plant lectins, and your complement system watching for that sugar signature to fire off a response. Ficolins are protein lectins that come in patterns of five at a time, and also set of the lectin pathway.
Here is the rub. There is now evidence that a low lectin diet will decrease endothelial dysfunction (code word for the first step in coronary artery disease).

What’s the final implied conclusion? This is a new way to look at heart disease. Lectins play a roll is setting off inflammation. That’s a given. Lectins in the human diet have increased dramatically in the last 200 years as our foods from all over the world have become part of a new diet that never had those foods before. And in the 21st century, we have added all sorts of chemicals to our environment that allow our gut to “leak”: NSAIDs like ibuprofen and naproxen, steroids, antibiotics, PPIs. And we have genetically modified many of our foods to create grains resistant to insects by intentionally inserting more lectins into the genome of plants that we then eat. We have tilted the playing field. The slope is in the wrong direction to maintain health.
WWW. What will work for me. I am eager to learn this stuff. I was at a small plate restaurant this weekend and intentionally chose a low lectin dinner: grilled Brussel’s sprouts and calamari. I slept better last night. Hmmm. Don’t know if that’s linked. One meal does not a heart attack prevent, but Gundry has shown that a low lectin diet will reduce damaged blood vessels “endothelial dysfunction” in just a few months. I’ve been off ibuprofen now for two weeks. Never again.

Pop Quiz

 

  1. The Complement System is the method of English Manners and Polite Behavior. T or F Answer: well, yes, true, but not here. In your immune system, it’s your kick boxer – the first line of defense against invasion. Not polite
  2. Lectins set off the complement system. T or F                               Answer: True. There are 3 pathways to set it off and one of them specifically is started with lectins.
  3. Many lectins have a simple sugar on them that is an ID of trouble. What is it?          Answer:   Mannose
  4. You can reduce endothelial dysfunction with a low lectin diet? (What’s that?  It’s part of what we simplify to call high blood pressure, but is a bigger picture of damaged blood vessel lining.)                                        Answer:  Today’s takeaway
  5. We have had an increase in lectins in our diet in the last 100 years?                            Answer: Not only an increase by new foods, but intentionally added to many foods by genetic engineering, feeding lectins to our animals, and then the coup de grace of adding leaky gut from modern chemicals.

 

Lectin Lesson 1: What Are Lectins?

References: Int Jr of Plant ChemJr Cereal SciNutrients,

Ever had someone tell you that they are allergic to wheat? You scoff and say they don’t have celiac disease. And they don’t. They are sensitive to LECTINS. And lots of people are. If you feel your tummy upset when you eat bread or wheat, read on. This is for you. Actually, this is for all of us.
What are lectins? Plants make them to deter animals and insects from eating the plant. They are poisons. They are plants main way to protecting themselves. And plants have been very clever in figuring out how to do that over millennia. They have devised may lectins that look very close to the normal proteins inside of animals, but not quite the same. You see, if you make a close copy that messes up the animal by making fake signals, you make it feel sick when it eats you. So it stops eating you.
What did we do with wheat? In the 1950s, Borlag crossed old fashioned wheat with two grasses to make wheat go from the 14 chromosomes of old fashioned natural wheat to the 42 chromosomes of modern wheat. All the lectins in grasses got carried along into the new wheat. Now mind you, lectins are at very tiny levels. They aren’t the main show like carbs, or protein, or fat. They are like hormones, active at extremely low doses. This is how they have gotten by below the redar up till now. This is why you haven’t heard about them.

But lectins work exactly at that level. They act at very tiny doses like trace hormones. In your body you have millions of TLRs, Toll Receptor Proteins that are basically bar code readers. They are lining your blood vessels looking for invading bacteria and viruses and poisons. When their bar code gets matched with an invading protein, they stimulate the making of chemical signals to call in help. Those signals are called cytokines and your body makes a whole mist of the cytokines. There are dozens, if not hundreds of cytokines that all rise in a chorus of response to make an integrated immune reaction to the invader.

That immune response is meant to make an animal avoid that plant. The animal and plant, living in the same ecosystem get used to each other. They learn to tolerate, and accommodate each other. The animal’s gut bacteria develop a tolerance and acceptance of the plants lectin poisons, and start making a healthy immune reaction that is good, when done in tiny doses.

That all happens when animals live in the same ecosystem and eat the same food for millions of years. Humans did that up till about a million years ago. Then we learned to cook. Cooking inactivates a lot of lectins, so humans could add many more foods to their diet. All was well and good, as long as we humans were living in Africa and the Mediterranean, where we had reliable, accommodated foods. But then the thunderbolt happened. We learned to grow wheat and lentils in the Levant. 10,000 years ago, we learned agriculture. This allowed us to make cities and armies and increase our population. We didn’t have to go hunting game and could have farms and armies and kings. But we were eating a new food our guts weren’t really used to. The lectins really weren’t all that good for us. Over the next 1000 years, we lost a foot in height, a decade in longevity, 15% off the size of our brain but eating lectin rich foods instead of wild game. But the bargain with the devil was already done, civilization had begun. What would come next?
Read next week.
WWW.What will work for me. We all need to learn about lectins and their subtle but incredibly perverse effect. This applies to me and you. The scope of lectins is really the story of all our modern diseases. This is the underpinnings of inflammation, the engine that drives our common modern illnesses. Read on. We need to know this.

 

Pop Quiz

  1. What are lectins?                        Answer: trace substances, usually proteins made by plants that function to deter insects and animals from eating the plant.
  2. Plants and the animals that eat them get used to each other over million of years. T or F Answer: True. So humans come out of Africa and have gut bacteria that are familiar with African plants.
  3. How do lectins do their function?                                   Answer: they have often evolved to look quite similar to proteins inside the animal: close but not quite so they make dysfunctional actions that make the animal sick.
  4. Lectins are detected in animals by their “what” system?                        Answer: TRP or Toll Receptor Proteins lining all blood vessels.
  5. When humans started eating wheat and lentils in the Fertile Crescent 10,000 years ago, what happened.                                                              Answer: Civilization got started in cities and settlements, but humans also got shorter with smaller brains.   Wheat and lentils both contained new lentils previously unknown to humans. 10,000 years is not enough time to evolve new defenses to new lectins.

 

Biotoxin XIV: Fixing TGF-beta 1

 

Biotoxin XIV: Fixing TGF-Beta1

References: Shoemaker ProtocolScienceWikipediaSci Rep 2017,

We are almost at the end of our Biotoxin Treatment Pathway. Fixing TGF-beta 1 is next to last. If your level is over 2380, you need to fix it. And fix it you can. What is it that TGF-beta 1 does? It’s a member of superfamily of cytokines in that it has myriad functions. It plays a key roll in cellular differentiation, proliferation, and finally apoptosis. Many cells secrete it and respond to it, so our understanding of it is just getting started. We do see it act badly in Marfan’s syndrome where folks are super stretchy and bendy and have a “wingspan” greater than their height. They often die from burst aortic aneurysms, caused by too much TGF-beta 1. In fact, someone whose wingspan is greater than their height is very likely to have an elevated TGFb1. Hmmm. Might you measure yours? If you have an autoimmune disease, know your wingspan, and your TGFb1, as fixing your mold illness may revert your BT illness. Cool, huh!
Levels of 5000 and below usually aren’t too sick but over 10,000 and you are almost certain to have some identifiable effect. Lung, joint, brain are common victims. For example, in the brain we know that glial cells put out Glial Fibrillatory Acidic Protein, that inhibits cell growth and axonal connections. In lungs we suspect that at many as 50% of adults developing new asthma are doing so from biotoxin illness with ‘TGF-beta 1 playing a leading roll.

TGF beta 1 drives the development of imbalance between T-regulatory CD4+CD25++ cells and TH-17 cells. This might be at the heart of autoimmunity. T-regulatory cells help prevent autoimmunity – the body attacking itself. In some with biotoxin illness, T-regulatory cells are improperly changed into pathogenic effector T-cells by TH-17 cells. The next effect is an endless positive feedback look driving more TGF beta 1. We can now measure CD4+CD25++ and CD4+CD25++127lo/- cells as one method of getting to the heart of this imbalance. Can you imagine if this works out to have a major impact on ALL autoimmune disease. That would be so amazing!

How do you fix it? Actually, it’s easy….well, sort of. Cozaar, or Losartan, yes – a high blood pressure mediation lowers TGFbeta 1. If it is above 2380, and particularly if T-regulatory CD4+CD25++ combo cell levels are less than 18, you need to be on Losartan. 25 mg twice a day will do most adults, but if blood pressure doesn’t drop too much, 50 mg a day will push it even faster. For how long? Until you are better. Not years, weeks. Maybe months. Provided you are out of the biotoxin environment and not being reignited with new inflammation. For those whose blood pressure is too low, VIP spray also works. (Next week).

What is it that Losartan does? Remember, you asked: here goes: “EXP3179, but not losartan and EXP3174, dose-dependently inhibited (P<0.05) phorbol myristate acetate and insulin-stimulated NADPH oxidase activity. EXP3179 also inhibited phorbol myristate acetate-induced NADPH oxidase in endothelial cells. In addition, EXP3179 inhibited (P<0.05) both phorbol myristate acetate-stimulated p47phox translocation from cytosol to membranes and protein kinase C activity.” Did you get that? I didn’t either till I read it three times. Remember, EXP3179 does it, not Losartan. But it does lower TGF-beta 1. Aren’t you relieved! Stupid little high blood pressure medicine, works wonders on TGFb1.

WWW.What will work for me. I’m seeing tons of folks with CIRS and mold illness with TGFb1 over 10,000. My highest has been 28,000 something and that person answered 29 symptoms on Shoemaker’s symptom list. Mostly they said their brain just didn’t work. Can you imagine the wonder I feel to see folks getting better from a mystery illness that heretofore went not only unrecognized, but blamed on the victim?  It’s like a Christmas present.

 

Pop Quiz:

1.     TGFb1 is ….?                                                                    Answer: a peptide cytokine that has regulatory properties for cell growth and differential, and eventually cell death. It plays a key role in facilitating autoimmune disease.

2.     It needs treatment to lower it when…?                       Answer If you feel sick and have levels over 2380,

3.     The best way to lower it is with a drug called…..?     Answer: Losartan

4.     How long do you have to treat for?                             Answer: until better with normal TGFb1, which might be a couple of weeks or months. Or VIP

5.     If you are “double jointed” and can bend your fingers back to your wrist or scratch the middle of our back easily, you might first want to measure what?                   Answer: Your wingspan, then your TGFb1.

 

 

 

Birth Method, Gut Bacteria and Health Outcomes

Birth Method and Health Outcomes via the Gut

Reference: JAMA Pediatrics Jan 2016

When a baby is born naturally, it usually is facing downwards. That makes it easiest to flex and turn its head through the vaginal canal. Now, recalling the 20 or so babies I’ve delivered in my career, I do recall that most of them squeeze out a bit of stool from mom’s rectum just before delivery. Pretty quickly, the babies face then emerges and the baby takes a deep breath and yells. We wipe the blood and stool and messy vaginal juices off their face and hand them over to mom.

What just happened? Mom just did one of her more important actions. She passed on her bacterial biome to the baby to populate its intestinal tract. The vaginal bacterial are heavily weighted to lactobacillus that digest milk just fine. And the 30,000 different species in mom’s intestinal biome get gifted to baby. They all get a healthy start. Now that we know that our colonic biome is critically linked to many health outcomes. This is a good thing. Guess what happens when you get delivered via a sterile C-section. You got it! Your gut gets a whole different start. Then, guess what good things breast feeding does for your gut biome! You got it. Dramatically better diversity and balance of bacteria when vaginally delivered versus c-section delivered.

That’s what Dr. And her team discovered following 102 deliveries of which. 70 were natural vaginal deliveries and 32 Were c- sections. Then 70 women exclusively breastfed,   26 Women breast fed and supplemented with some formula and 6 exclusively bottle fed. At 6 weeks the babies had their colonic biome evaluated.

And this is where it gets really interesting. Being delivered vaginally results in 6 bacterial families having statistically different abundance. This constituted a greater change in abundance and distribution of bacterial families than breast feeding versus formula feeding. In that, there was difference enough.   Pure breastfeeding showed a different population of bacteria in the babies colonic biome than formula feeding. Interestingly enough, adding some formula in made if as though you were only formula feeding, losing the benefit of breast feeding.

Cesarean delivery has been associated with an increased risk for obesity, asthma, celiac disease, and type 1 diabetes mellitus. That is at least 3 autoimmune illnesses that have a connection to type of birth. Don’t you find that intriguing? It suggests that the cross talk between the bacteria in your colon and your immune system is far more complex, and more beneficial than we have understood to date. Our colon is emphatically not just an organ dedicated to conserving water, but rather a complicated, mutually beneficial arrangement with implications we have yet to fully understand.

The implication is pretty clear to me. If you are forced by circumstance to have a C-section for your baby’s delivery, you might be well served to make sure your baby gets a taste of your vaginal bacteria, and some of your stool. And then, breastfed, exclusively.   This study is in progress, and its results should be coming soon. How about a cotton swab?   We already know that kids who grow up on farms with early exposure to animal dander and poop have fewer allergies. Perhaps it’s all by the same route. More diversity.

www.What Will Work for me.   I’m getting a lot more casual about the dirt in my environment. I’m trying to still wash my hands and my fruit/vegetables, just to get off all the pesticides and viruses I picked up off the door nob. But the mud from my yard….may be just what I need. What I want to learn is how to interpret the variety of bacteria when I test it, and I haven’t found a good source to help me sort that out. That is still a work in progress.

 

Pop Quiz

 

  1. You get beneficial bacteria from your mother’s stool at the moment of birth. T or F

True, get over it.

  1. Vaginal delivery results in a very different bacterial biome from c-section delivery. T or F

True

  1. C-section babies get their bacteria from the nurses in the delivery suite, their husbands, the doctor and the nurses assistant, instead of from mom. T or F

True

  1. Breast feeding exclusively appears to provide added benefit for colonic diversity and abundance, a benefit lost with modest formula supplementation.   T or F

Again True

  1. In the future, it may be standard of care to swab a mother’s vagina and rectum to pass on bacteria to a baby at birth, if the baby was born by c-section.

May be. Makes perfect sense. And time is of the essence.