Category Archives: 19. Autoimmune Disease

Fast Mimicking Diet 3: The Fasting Part

Fast Mimicking Diet 3 The Fast Mimicking

References: Longo: The Longevity Diet, [Science], Science DirectCellCell Metabolism,

I like to eat. I get hungry. What is it about fasting that makes me do better? Let’s review. Valter Longo found that there were two processes in yeast (very primitive organism) and mice (sophisticated mammalian organism) that respond in the same way. RAS and TOR. Those are the two pathways that appear to accelerate aging. Sugar turns on RAS-PKA and extra protein turns on TOR-6SK Growth Hormone Pathway. If you can down regulate the RAS pathway, you increase the rate of clearing out old, dead, malfunctioning tissues and organelles. That’s called autophagy. TOR is an internal monitor of nutrient density and controller of cell growth. Can’t grow if you don’t have enough food. Dial TOR down and cells stop dividing and go into hunker down mode. Alter those two pathways and presto, chango, you have gotten to the root cause of aging in humans. That discovery, that these two pathways are fundamental to all life on this planet, starting with yeast and moving all the way up to humans, is Longo’s key contribution to modern understanding of aging.
Fasting turns both those pathways in the right direction. It takes about 24 hours to use up the glucose in your liver, stored as glycogen. The human body then switches to burning fat from stores in fat cells. The brain and body utilize ketone bodies in a process termed ketolysis, in which acetoacetic acid and 3-β-hydroxybutyrate are converted into acetoacetyl-CoA and then acetyl-CoA. In yeast, glucose, acetic acid and ethanol, but not glycerol which is also generated during fasting from the breakdown of fats, accelerate aging. Not glycerol. Did you get that? There is one carbon source that doesn’t turn on the nutrient recognition pathway. Glycerol is the 3 carbon fragment that holds fats together in tri-“glycerides”.

Fasting for 3 or more days in humans causes a 30% decrease in circulating insulin and glucose, as well as a reduced level of insulin-like growth factor 1 (IGF-1), the major growth factor in mammals, which together with insulin is associated with accelerated aging and cancer. Fasting for five days results in a 60% decrease in IGF-1and a 5-fold or higher increase in one of the main IGF-1-inhibiting proteins: IGFBP1. This effect on IGF-1is mostly due to protein restriction, and particularly to the restriction of essential amino acids, but is also supported by calorie restriction since the decrease in insulin levels during fasting promotes reduction in IGF-1. In humans, chronic fasting does not lead to a decrease in IGF-1 unless combined with protein restriction.
Did you get all that? It’s the protein restriction that matters. Five days appears to be the time period in which maximum reduction of cancer growth factors and insulin occurs. You can trick the system with some glycerol which doesn’t register as a sensed nutrient. And we have some markers of metabolism to show your success. 5 days. Reduced protein, animal in particular. Cut the calories down to low enough to turn on and maintain ketogenesis. Sounds like about 800 a day will work. The goal isn’t to lose weight but to turn on anti-aging genes.

WWW. What will work for me. Well, I’ve finished one cycle for myself and lost 6 pounds while doing it and another two pounds over the subsequent three weeks. Not bad. I’m going to do two more cycles and then repeat my own lab tests. Glycerol makes an interesting little sport drink. It’s slightly sweet and with a bit of flavor added from a tea, it’s not so bad. I’ve bought some hibiscus tea.

Pop Quiz

 

  1. What nutrient can you consume that is slightly sweet and doesn’t trigger calorie sensing? Answer: Glycerol
  2. What amino acid turns on aging, and absence turns off aging? Answer: leucine in particular.
  3. Five day fasting results in a 60% decrease in what? Answer: IGF-1 or our Growth Hormone surrogate marker.
  4. Along with that, you get up to a 5 fold INCREASE in what IGF-1 inhibitor? Answer: IGFBP1.
  5. What lab tests might you want to know if you were getting success in your fasting methods? Answer: Glucose, insulin, IGF-1 and IGFBP-1

 

Lectin Lesson 4: What Elephants Having Heart Attacks Teaches Us About Cancer

References: Steven Gundry’s The Plant Paradox, CirculationScience Direct,Front Oncol., Glycobiology,

Ok, caught your attention? Elephants having heart attacks? Yes, it’s true. Now, when elephants live in their natural habitat that has sufficient tree and brush forage, they never get a heart attack. In the last couple of hundred years they have lost habitat and been driven to eating grasses. Elephants don’t eat grass when they have natural leaf habitat – they eat leaves. When they eat grass they develop coronary disease, just like us. Why does that happen?
We share an odd and uncommon sugar with elephants. It is called Neu5ac. I’ll call it N-A. It’s a member of the sialic acid family of sugars. We share it with shellfish, chickens and elephants. When we diverged from chimps 8 million years ago, we started making Neu5ac (N-A). Chimps make Neu5gc (N-G). As do every other mammal including the ones we eat like cows, goats, sheep, pigs. This sugar, N-A) is like a signal in our gut cells and our arteries. And grain based lectins bind avidly to it. WGA, the lectin in the wheat germ, binds avidly to it. Avidly. But grain lectins don’t bind to N-G.
Here’s where the link happens. When we eat red meat containing Neu5gc – N-G, your immune system recognizes it as foreign and makes antibodies to it. Those antibodies then turn around and attack your own Neu5ac (N-A) receptors. You get antibodies on your blood vessel walls. You call in white cells. Coronary artery disease is off and running. When elephants eat grasses, they get the same cross reactivity. Something about having grass (wheat) based lectins that attach to Neu5ac and eating the Neu5gc form of the sugars makes for that autoimmune attack.
Now, swing over to cancer. Human cancers have a lot of the Neu5gc protein in them. They put it on their surface as a means of hiding from our immune system. Wait a minute! We don’t make it. Human cells cannot make Neu5gc. Right, we don’t. Then how does the cancer get it? From our eating it in red meat. That may be the link between our eating excessive red meat, and having more cancer. The more red meat you eat, the more N-G you get to supply cancer cells with camouflage. Did you notice that chicken and shell fish don’t have N-G. They have N-A, just like humans and elephants. When you eat chicken and shell fish, you have less risk of heart disease and cancer.

The mechanism that is driving both of these phenomenon is the presence of these sialic acid sugars called Neu5ac versus Neu5gc. Their subtle name difference is the whole universe of immune recognition. That simple little alteration is all it takes for your immune system to go the wrong direction and start a process that leads to the slippery slope of coronary artery disease, or cancer.

WWW. What will work for me. This is a smoking gun. It tells us the clear mechanism by which this elegant, delicate signaling system shifts our immune reaction against either ourselves or against our own immune vessels. Or cancer. It’s simple. We get B12 from red meat. We have to have it. A tiny bit. I mean tiny bit. Seems like we need to start thinking about how we can change the balance of calories. If ketogenic eating is important for our brains, then it has to be with healthy fats, not meat. And it all comes down to those magnificent gentle animals, elephants.

Pop Quiz

 

  1. Elephants were designed to eat grasses? T or F                                               Answer: False Leaves
  2. When elephants eat grasses they develop what illness in common with humans?           Answer: Coronary artery disease
  3. The key link in the immune response is a lectin binding sugar called?                             Answer: Neu5ac – a member of the sialic acid family of sugars
  4. The principal damaging lectin in wheat, WGA binds to which of the two sialic acids – Neu5gc or Neu5ac?                                                                                                                                Answer: N-A not N-G
  5. Human cancer cells get their camouflage from?                                        Answer:     Red meat Neu5ga.

 

 

Lectin Lesson 2: How Lectins Cause Damage with Inflammation

References: American Heart Sci Meetings,Jr, ImmunologyResearchgateWikipediaAthersclerosis,

Just what is going on with lectins? What’s the big deal? Do they really cause trouble?

To understand those questions, you have to understand the complement system in your body. This is not about saying a nice thing to you about your hair, or your necklace, this is about your basic lizard brain immune system, your innate immune system. Your innate immune system is the first to respond to threats with non-specific responses. If you think of a series of dominoes, each of which knocks over two more, the innate immune system is the means by which your body kicks back immediately against external threats and makes immediate reactions that happens quickly in response to “invasion”. A cascade of chemicals create tags to place on the invader to tell a white cell to eat that particular invader, (Opsonization is the fancy term) or punches a hole in the wall of the invader with donut shaped proteins so the invader leaks its guts out. You can imagine, this has to be carefully controlled as if it balloons out of control, you get the shaft and your own cells get damaged. The adaptive system, layer two of your immune response, takes longer to gear up and make specific antibodies shaped precisely to attack the invader, or specific white cells armed with bar code readers to find and destroy the invader. Doing all that takes time. In the short term, the complement system is it.
There are several pathways into the complement system. The classical pathway, the alternative pathway and the LECTIN PATHWAY. Did you get that? The lectin pathway is one of the ways you set off your innate immune system. To understand this pathway you have to be able to read the following sentences without pausing: This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) to microbial surface oligosaccharides and acetylated residues, respectively. Upon binding to target molecules, MBL, CL-K1, and ficolins form complexes with MBL-associated serine proteases 1 and 2 (MASP-1 and MASP-2), which cleave C4 and C2 forming the C3 convertase (C4b2a). If you drill down into that, it simplifies to the sugar mannose that is part of many plant lectins, and your complement system watching for that sugar signature to fire off a response. Ficolins are protein lectins that come in patterns of five at a time, and also set of the lectin pathway.
Here is the rub. There is now evidence that a low lectin diet will decrease endothelial dysfunction (code word for the first step in coronary artery disease).

What’s the final implied conclusion? This is a new way to look at heart disease. Lectins play a roll is setting off inflammation. That’s a given. Lectins in the human diet have increased dramatically in the last 200 years as our foods from all over the world have become part of a new diet that never had those foods before. And in the 21st century, we have added all sorts of chemicals to our environment that allow our gut to “leak”: NSAIDs like ibuprofen and naproxen, steroids, antibiotics, PPIs. And we have genetically modified many of our foods to create grains resistant to insects by intentionally inserting more lectins into the genome of plants that we then eat. We have tilted the playing field. The slope is in the wrong direction to maintain health.
WWW. What will work for me. I am eager to learn this stuff. I was at a small plate restaurant this weekend and intentionally chose a low lectin dinner: grilled Brussel’s sprouts and calamari. I slept better last night. Hmmm. Don’t know if that’s linked. One meal does not a heart attack prevent, but Gundry has shown that a low lectin diet will reduce damaged blood vessels “endothelial dysfunction” in just a few months. I’ve been off ibuprofen now for two weeks. Never again.

Pop Quiz

 

  1. The Complement System is the method of English Manners and Polite Behavior. T or F Answer: well, yes, true, but not here. In your immune system, it’s your kick boxer – the first line of defense against invasion. Not polite
  2. Lectins set off the complement system. T or F                               Answer: True. There are 3 pathways to set it off and one of them specifically is started with lectins.
  3. Many lectins have a simple sugar on them that is an ID of trouble. What is it?          Answer:   Mannose
  4. You can reduce endothelial dysfunction with a low lectin diet? (What’s that?  It’s part of what we simplify to call high blood pressure, but is a bigger picture of damaged blood vessel lining.)                                        Answer:  Today’s takeaway
  5. We have had an increase in lectins in our diet in the last 100 years?                            Answer: Not only an increase by new foods, but intentionally added to many foods by genetic engineering, feeding lectins to our animals, and then the coup de grace of adding leaky gut from modern chemicals.

 

Lectin Lesson 1: What Are Lectins?

References: Int Jr of Plant ChemJr Cereal SciNutrients,

Ever had someone tell you that they are allergic to wheat? You scoff and say they don’t have celiac disease. And they don’t. They are sensitive to LECTINS. And lots of people are. If you feel your tummy upset when you eat bread or wheat, read on. This is for you. Actually, this is for all of us.
What are lectins? Plants make them to deter animals and insects from eating the plant. They are poisons. They are plants main way to protecting themselves. And plants have been very clever in figuring out how to do that over millennia. They have devised may lectins that look very close to the normal proteins inside of animals, but not quite the same. You see, if you make a close copy that messes up the animal by making fake signals, you make it feel sick when it eats you. So it stops eating you.
What did we do with wheat? In the 1950s, Borlag crossed old fashioned wheat with two grasses to make wheat go from the 14 chromosomes of old fashioned natural wheat to the 42 chromosomes of modern wheat. All the lectins in grasses got carried along into the new wheat. Now mind you, lectins are at very tiny levels. They aren’t the main show like carbs, or protein, or fat. They are like hormones, active at extremely low doses. This is how they have gotten by below the redar up till now. This is why you haven’t heard about them.

But lectins work exactly at that level. They act at very tiny doses like trace hormones. In your body you have millions of TLRs, Toll Receptor Proteins that are basically bar code readers. They are lining your blood vessels looking for invading bacteria and viruses and poisons. When their bar code gets matched with an invading protein, they stimulate the making of chemical signals to call in help. Those signals are called cytokines and your body makes a whole mist of the cytokines. There are dozens, if not hundreds of cytokines that all rise in a chorus of response to make an integrated immune reaction to the invader.

That immune response is meant to make an animal avoid that plant. The animal and plant, living in the same ecosystem get used to each other. They learn to tolerate, and accommodate each other. The animal’s gut bacteria develop a tolerance and acceptance of the plants lectin poisons, and start making a healthy immune reaction that is good, when done in tiny doses.

That all happens when animals live in the same ecosystem and eat the same food for millions of years. Humans did that up till about a million years ago. Then we learned to cook. Cooking inactivates a lot of lectins, so humans could add many more foods to their diet. All was well and good, as long as we humans were living in Africa and the Mediterranean, where we had reliable, accommodated foods. But then the thunderbolt happened. We learned to grow wheat and lentils in the Levant. 10,000 years ago, we learned agriculture. This allowed us to make cities and armies and increase our population. We didn’t have to go hunting game and could have farms and armies and kings. But we were eating a new food our guts weren’t really used to. The lectins really weren’t all that good for us. Over the next 1000 years, we lost a foot in height, a decade in longevity, 15% off the size of our brain but eating lectin rich foods instead of wild game. But the bargain with the devil was already done, civilization had begun. What would come next?
Read next week.
WWW.What will work for me. We all need to learn about lectins and their subtle but incredibly perverse effect. This applies to me and you. The scope of lectins is really the story of all our modern diseases. This is the underpinnings of inflammation, the engine that drives our common modern illnesses. Read on. We need to know this.

 

Pop Quiz

  1. What are lectins?                        Answer: trace substances, usually proteins made by plants that function to deter insects and animals from eating the plant.
  2. Plants and the animals that eat them get used to each other over million of years. T or F Answer: True. So humans come out of Africa and have gut bacteria that are familiar with African plants.
  3. How do lectins do their function?                                   Answer: they have often evolved to look quite similar to proteins inside the animal: close but not quite so they make dysfunctional actions that make the animal sick.
  4. Lectins are detected in animals by their “what” system?                        Answer: TRP or Toll Receptor Proteins lining all blood vessels.
  5. When humans started eating wheat and lentils in the Fertile Crescent 10,000 years ago, what happened.                                                              Answer: Civilization got started in cities and settlements, but humans also got shorter with smaller brains.   Wheat and lentils both contained new lentils previously unknown to humans. 10,000 years is not enough time to evolve new defenses to new lectins.

 

Biotoxin XIV: Fixing TGF-beta 1

 

Biotoxin XIV: Fixing TGF-Beta1

References: Shoemaker ProtocolScienceWikipediaSci Rep 2017,

We are almost at the end of our Biotoxin Treatment Pathway. Fixing TGF-beta 1 is next to last. If your level is over 2380, you need to fix it. And fix it you can. What is it that TGF-beta 1 does? It’s a member of superfamily of cytokines in that it has myriad functions. It plays a key roll in cellular differentiation, proliferation, and finally apoptosis. Many cells secrete it and respond to it, so our understanding of it is just getting started. We do see it act badly in Marfan’s syndrome where folks are super stretchy and bendy and have a “wingspan” greater than their height. They often die from burst aortic aneurysms, caused by too much TGF-beta 1. In fact, someone whose wingspan is greater than their height is very likely to have an elevated TGFb1. Hmmm. Might you measure yours? If you have an autoimmune disease, know your wingspan, and your TGFb1, as fixing your mold illness may revert your BT illness. Cool, huh!
Levels of 5000 and below usually aren’t too sick but over 10,000 and you are almost certain to have some identifiable effect. Lung, joint, brain are common victims. For example, in the brain we know that glial cells put out Glial Fibrillatory Acidic Protein, that inhibits cell growth and axonal connections. In lungs we suspect that at many as 50% of adults developing new asthma are doing so from biotoxin illness with ‘TGF-beta 1 playing a leading roll.

TGF beta 1 drives the development of imbalance between T-regulatory CD4+CD25++ cells and TH-17 cells. This might be at the heart of autoimmunity. T-regulatory cells help prevent autoimmunity – the body attacking itself. In some with biotoxin illness, T-regulatory cells are improperly changed into pathogenic effector T-cells by TH-17 cells. The next effect is an endless positive feedback look driving more TGF beta 1. We can now measure CD4+CD25++ and CD4+CD25++127lo/- cells as one method of getting to the heart of this imbalance. Can you imagine if this works out to have a major impact on ALL autoimmune disease. That would be so amazing!

How do you fix it? Actually, it’s easy….well, sort of. Cozaar, or Losartan, yes – a high blood pressure mediation lowers TGFbeta 1. If it is above 2380, and particularly if T-regulatory CD4+CD25++ combo cell levels are less than 18, you need to be on Losartan. 25 mg twice a day will do most adults, but if blood pressure doesn’t drop too much, 50 mg a day will push it even faster. For how long? Until you are better. Not years, weeks. Maybe months. Provided you are out of the biotoxin environment and not being reignited with new inflammation. For those whose blood pressure is too low, VIP spray also works. (Next week).

What is it that Losartan does? Remember, you asked: here goes: “EXP3179, but not losartan and EXP3174, dose-dependently inhibited (P<0.05) phorbol myristate acetate and insulin-stimulated NADPH oxidase activity. EXP3179 also inhibited phorbol myristate acetate-induced NADPH oxidase in endothelial cells. In addition, EXP3179 inhibited (P<0.05) both phorbol myristate acetate-stimulated p47phox translocation from cytosol to membranes and protein kinase C activity.” Did you get that? I didn’t either till I read it three times. Remember, EXP3179 does it, not Losartan. But it does lower TGF-beta 1. Aren’t you relieved! Stupid little high blood pressure medicine, works wonders on TGFb1.

WWW.What will work for me. I’m seeing tons of folks with CIRS and mold illness with TGFb1 over 10,000. My highest has been 28,000 something and that person answered 29 symptoms on Shoemaker’s symptom list. Mostly they said their brain just didn’t work. Can you imagine the wonder I feel to see folks getting better from a mystery illness that heretofore went not only unrecognized, but blamed on the victim?  It’s like a Christmas present.

 

Pop Quiz:

1.     TGFb1 is ….?                                                                    Answer: a peptide cytokine that has regulatory properties for cell growth and differential, and eventually cell death. It plays a key role in facilitating autoimmune disease.

2.     It needs treatment to lower it when…?                       Answer If you feel sick and have levels over 2380,

3.     The best way to lower it is with a drug called…..?     Answer: Losartan

4.     How long do you have to treat for?                             Answer: until better with normal TGFb1, which might be a couple of weeks or months. Or VIP

5.     If you are “double jointed” and can bend your fingers back to your wrist or scratch the middle of our back easily, you might first want to measure what?                   Answer: Your wingspan, then your TGFb1.

 

 

 

Birth Method, Gut Bacteria and Health Outcomes

Birth Method and Health Outcomes via the Gut

Reference: JAMA Pediatrics Jan 2016

When a baby is born naturally, it usually is facing downwards. That makes it easiest to flex and turn its head through the vaginal canal. Now, recalling the 20 or so babies I’ve delivered in my career, I do recall that most of them squeeze out a bit of stool from mom’s rectum just before delivery. Pretty quickly, the babies face then emerges and the baby takes a deep breath and yells. We wipe the blood and stool and messy vaginal juices off their face and hand them over to mom.

What just happened? Mom just did one of her more important actions. She passed on her bacterial biome to the baby to populate its intestinal tract. The vaginal bacterial are heavily weighted to lactobacillus that digest milk just fine. And the 30,000 different species in mom’s intestinal biome get gifted to baby. They all get a healthy start. Now that we know that our colonic biome is critically linked to many health outcomes. This is a good thing. Guess what happens when you get delivered via a sterile C-section. You got it! Your gut gets a whole different start. Then, guess what good things breast feeding does for your gut biome! You got it. Dramatically better diversity and balance of bacteria when vaginally delivered versus c-section delivered.

That’s what Dr. And her team discovered following 102 deliveries of which. 70 were natural vaginal deliveries and 32 Were c- sections. Then 70 women exclusively breastfed,   26 Women breast fed and supplemented with some formula and 6 exclusively bottle fed. At 6 weeks the babies had their colonic biome evaluated.

And this is where it gets really interesting. Being delivered vaginally results in 6 bacterial families having statistically different abundance. This constituted a greater change in abundance and distribution of bacterial families than breast feeding versus formula feeding. In that, there was difference enough.   Pure breastfeeding showed a different population of bacteria in the babies colonic biome than formula feeding. Interestingly enough, adding some formula in made if as though you were only formula feeding, losing the benefit of breast feeding.

Cesarean delivery has been associated with an increased risk for obesity, asthma, celiac disease, and type 1 diabetes mellitus. That is at least 3 autoimmune illnesses that have a connection to type of birth. Don’t you find that intriguing? It suggests that the cross talk between the bacteria in your colon and your immune system is far more complex, and more beneficial than we have understood to date. Our colon is emphatically not just an organ dedicated to conserving water, but rather a complicated, mutually beneficial arrangement with implications we have yet to fully understand.

The implication is pretty clear to me. If you are forced by circumstance to have a C-section for your baby’s delivery, you might be well served to make sure your baby gets a taste of your vaginal bacteria, and some of your stool. And then, breastfed, exclusively.   This study is in progress, and its results should be coming soon. How about a cotton swab?   We already know that kids who grow up on farms with early exposure to animal dander and poop have fewer allergies. Perhaps it’s all by the same route. More diversity.

www.What Will Work for me.   I’m getting a lot more casual about the dirt in my environment. I’m trying to still wash my hands and my fruit/vegetables, just to get off all the pesticides and viruses I picked up off the door nob. But the mud from my yard….may be just what I need. What I want to learn is how to interpret the variety of bacteria when I test it, and I haven’t found a good source to help me sort that out. That is still a work in progress.

 

Pop Quiz

 

  1. You get beneficial bacteria from your mother’s stool at the moment of birth. T or F

True, get over it.

  1. Vaginal delivery results in a very different bacterial biome from c-section delivery. T or F

True

  1. C-section babies get their bacteria from the nurses in the delivery suite, their husbands, the doctor and the nurses assistant, instead of from mom. T or F

True

  1. Breast feeding exclusively appears to provide added benefit for colonic diversity and abundance, a benefit lost with modest formula supplementation.   T or F

Again True

  1. In the future, it may be standard of care to swab a mother’s vagina and rectum to pass on bacteria to a baby at birth, if the baby was born by c-section.

May be. Makes perfect sense. And time is of the essence.

The Devil in Milk: The A1 Casein vs A2 Conundrum

The Devil In Milk: the A1 vs A2 Protein Story

Sept 21, 2015

Reference: The Devil in Milk by Keith Woodford Diabetologia Elliott

Did you know that there are several forms of milk? The protein casein is not the same in every cow. Most European cows have what is called A1 casein. Most Asian cows have A2 casein. Casein is about 30% of the protein in human milk, but 80% in cows’ milk. At position 67, A1 milk has a histidine amino acid, A2 has a proline amino acid.   Beta-casomorphine-7 (BCM-7) is a 7 amino acid peptide that is released when you eat A1 milk, but not when you eat A2 milk.   BCM-7 is a morphine type chemical that can be blocked by naloxone.

Now, there is all sorts of interesting epidemiology around milk. For example, you can show that populations that drink more A1 milk have more insulin dependent diabetes in them in children, and more heart disease in adults. You can also find that Samoan children, raised in Samoa don’t get insulin dependent diabetes, but raised in New Zealand, they do. If you take mice that are genetically sensitized to getting diabetes, and feed them either A1 or A2 milk, you can show that 47% of the mice fed A1 milk got insulin dependent diabetes, but non of the A2 fed mice did. And if you feed them A1 milk, but block BCM-7 with naloxone, they still don’t get the diabetes they otherwise would have developed.

Now, this is where this topic goes down a “rabbit hole” of controversy. Most of the big dairy money in the world that trades milk internationally, uses A1 milk. That means they are in deep trouble if this data is true. A1 milk might be dangerous for you. The dairy trade would collapse. That would mean it would be in “big milk’s” best interest to deny, degrade, denigrate, obfuscate and attack anything they can about this issue. And they have. It is possible to change over a dairy herd from A1 to A2, but it takes about 10 years of time to breed new cows and get the genes into them with proper breeding.   It can be done. It just takes 10 years.

And there continues to be data about the dangers of A1 milk. There was a patent application in New Zealand claiming that autism has a strong correlation to the consumption of A1 mild.   That application was made by the company denigrating the original research, and then withdrawn and never published in the medical literature. Oh, the intrigue!   So, more epidemiology: the Masai in Africa have A2 milk, and drink 7 liters a day. No heart disease. In Europe, the Finns drink only A1 milk and have lots of heart disease. The French have mostly A2 milk, and have half the heart disease. On and on…

What’s happening in Wisconsin?   There are some herds in Wisconsin that are being converted by using A2 bulls.   Some of the alternative media is beginning to run articles on it.   New Zealand seems to be leading the pack in developing an A2 herd. But there remains controversy. And some of that controversy appears to be research that proves the opposite, but was in fact, intentionally sabotaged with BCM7 protein, and should be actually takes as proof of the fact it was trying to unseat. Isn’t the intrigue a riot? Like a detective novel.

WWW.   What do I think of all this?   I believe there to be some truth to it all. Not certain how deep, but I trust passionate truth tellers more than corporate monied interests. Between Johne’s Disease in cows (paratuberculosis that I think may be the cause of Crohn’s Disease) and concerns about how proteins are altered with pasteurizing, I don’t drink much milk.   If I could find A2 milk from a single herd that was Johne’s free, I might reconsider.   I’m certainly going to think about it and pay attention to it. And likely to tell more clients to avoid milk, unless it’s A2.

 

Pop Quiz

  1. Our current milk supply in America is digested into a product that has morphine like qualities to it?   T or F

True

  1. American Milk is primarily A1 milk which is a genetic variation off the original aboriginal milk, now found in Asian and African cows, called A2 milk (even though it was the original).   T or F

True. You are now getting the gist of this article.

  1. There are epidemiological studies connecting A2 milk to heart disease and insulin dependent diabetes. T or F

False. That’s backwards, it’s A1 that is connected to those two.   And autism, and Crohns, and, and, and…

  1. You can convert a herd of cows to being A2 cows by using only an A2 bull for about 10 years.   T or F

True. And it’s happening right now in a bunch of Wisconsin herds.

  1. One little amino acid substitution at position 67 out of over 200 amino acids is all it takes to make this mystery mysterious?   T or F

True. Amazing, isn’t it. But the same can be said for Sickle Cell and many other conditions.

 

Nrf2

NRF2

Reference: NRF2.com, Pall in APS, Thieme, Wikipedia, Science Direct

August 3, 2015

Ever heard of Nrf? (Nuclear factor erythroid derived) I bet you thought Nerfs were some blue cartoon character, or better yet, a foam ball with which you could play office basketball. Not so. Nrf 2 is a protein that is in every tissue in your body, waiting in your cells to be activated. It has a controlling protein that limits its activity until something bad comes along to activate it.   It then travels into your cell nucleus and turns on all the processes that protect your cell from damage by binding to the hARE (human Antioxidant Response Element) region of DNA.   hARE is the uber regulator of all antioxidant response systems in your cell.

With such activation, your cells turn on a very wide array of cell protection pathways. This places NRF smack dab in the middle of your fundamental cell protection mechanisms. Its breakdown logically follows as being central to many illnesses.   Free radicals floating around in your blood appear to be some of the strongest activators of the NRF system suggesting that oxidative stress plays a huge role in many illnesses: Metabolic syndrome, Autoimmune, inflammatory bowel, HIV, MS, epilepsy, chronic kidney disease, asthma, pulmonary fibrosis, sepsis, atherosclerosis.   With that, it logically follows that raising NRF will help treat many of those illnesses.

This is not to claim that NRF is your sole cell protective mechanism. Glutathione is also critical.   What is interesting is the link between the two.   Each of the three genes that encode for the production of the glutathione producing enzymes are individually activated by NRF. As is the gene that turns on glutathione reductase, the enzyme that converts used glutathione back into activated glutathione. As is the gene that turns on the 8 steps to make NADH, the energy source for glutathione. This makes NRF2 and glutathione closely integrated into a system that handles “oxidative stress”.

What causes that stress?   There is increasing evidence that our lifestyle of highly refined carbohydrates, made into products like flour (from any source) which is quickly digested and stimulates the production of insulin, leads to oxidative stress. Once we are overweight, our fat cells then produce showers of activating chemicals that keep it going.   It’s not just being overweight that does it. We live in a sea of chemicals in our modern world, many of which contribute a small part and which, cumulatively add up to a lot of harm.   Heavy metals are particularly bad players.

The $ 64 question then remains, “How do we activate Nrf2 and turn all that bad stuff off?”.   Here is a partial list:   the phenolic antioxidants (code for spices and herbs like turmeric, rosemary, thyme,), the gamma-delta tocotrienols, the isothionates (code word for broccoli and other kale family plants), allyl sulfides (code word for garlic and onions) , carotenoids (lycopene in particular – aka carrots and tomatoes), fish oil, fasting and exercise.   Hmm.   Sounds like a healthy diet.     This sounds like how coffee, chocolate, turmeric, olive oil, broccoli, red hot peppers, green tea, resveratrol, garlic, blueberries, rosemary, oregano, sage all work to prevent diseases like cancer. And at last, I’ve figured out where peroxide (H202) works – it turns on Nrf2).

WWW. What will work for me?   I don’t know how to measure the effects of Nrf2 activation but I believe it is real. There are pills out there touting their ability to activate Nrf2. I’ve given peroxide IV for inflammation and seen great results.   I just want a test to show that it’s working. That doesn’t exist yet. Back to eating a meal packed with tomatoes, garlic, broccoli, hot peppers, turmeric and resveratrol. Sounds like curry with red wine.

 

Pop Quiz

  1. Nrf2 is the common pathway to turn on inflammation. T or F

False. That would be NFκB – another common pathway in every cell but it turns on the fire. Nrf turns it off.

  1. Nrf2 activation is turned off by our modern lifestyle. T or F

True – particularly our consumption of refined carbohydrates.

  1. Fasting turns on Nrf2. T or F

True

  1. Tomatoes and broccoli, blueberries, olive oil all turn it on? T or F

True

  1. We don’t have a good measure to see turned on Nrf2 is? T or F

True, except for how you feel when you have a chronic disease.

The Trouble with Root Canals

The Trouble with Root Canals

Reference: Root Canal Coverup, Meinig

Ever had a toothache and ended up with a root canal?   Did it come back? Were you cured? Do you have a chronic, unexplained condition from which you can’t recover? An autoimmune disease? Are you losing weight, and don’t know why?

Westin Price was just fascinated with this problem. He was a dentist back in the 1920-30s in Cleveland who should be rated as one of America’s genius scientists.   Aside from that interest, he also traveled all over the world, taking pictures of peoples’ teeth and studying their diets, and concluding many of the findings of modern day nutrition 70 years before the rest of us caught up (He discovered Vitamin K2 15 years before the Nobel Prize folks gave it to someone else.). But he also did a huge body of research connecting inflamed, infected teeth with other medical conditions.

Many of his experiments involved removing infected teeth from folks with chronic medical conditions, and then observing their chronic medical condition improve dramatically. He then implanted those teeth into health rabbits and observed them to become ill also, with the equivalent illness the human had. And not just once or twice, but several thousand times. He produced a huge body of research that has laid undiscovered for some 50 years, and is only now being studied and found by credible dentists (Meinig was the president of the American Endodontal Association – and made his living for years doing root canals.)

Here are a few of the pertinent facts he worked with or “proved” that you should know.   Your teeth are not solid. Even the hard dentin is filled with miles of tiny channels that bacteria can hide in. When you have a root canal and have the tooth put back in, it’s still infected. You can’t fix it with antibiotics, as the antibiotics just don’t penetrate into the tooth. You may not be sick, after a root canal, but years later when you have extra stress in your life, like a car accident, a divorce, a death in the family, you are more likely to come down with a chronic disease. Modern dentists will tell you that the tooth is safe, and nothing can get out. It may be that the bacteria can’t get out, but Westin Price did elegant experiments that showed that the toxins get out.   Those toxins play havoc with your immune system, triggering exaggerated responses and thereby starting many other illnesses.

He also had pictures of bacteria in the dentin tubules of infected teeth in his textbook.   Price would take inflamed teeth out of folks, then cut open the dentin, culture the bacteria he found inside, filter the bacteria out but just leave the toxins in the fluid, and inject that fluid into rabbits. He did it over 1,600 times, and always found the same results. The rabbits got sick and died, or developed the same or equivalent illnesses the humans had.

One of the unique findings that I find fascinating is what sugar does to the flow of fluid in dentin. Usually the flow is outward from the inner body of the tooth. With sugar ingestion, your tooth reverses flow and dentin flow goes inward. That allows bacteria to penetrate and take up shop in your teeth. This was not discovered by Price but corroborates his findings and gives a credible explanation for how our modern diet causes so much tooth decay. He did show they then change from oxygen consuming to being able to live without oxygen, and start secreting toxins. And then, with enough of the right stress at the right time, you get sick.

WWW. What will work for me. If you have an unexplained illness, look at your teeth. Do you have gum disease? Are you losing weight and just can’t keep it on? Do you brush AND floss daily?   Are you going crazy with symptoms you can’t figure out?   If you are desperate and are grasping at straws, read this book. It may be a lifeline for you. This knowledge was discovered back in the 20s by one of our genius scientists, and got lost for 70 years. I’m certainly going to floss a lot more. And eat much less sugar.

 

Pop Quiz

  1. A diet heavy in sugar changes the flow of fluid in your teeth? T or F

True. It reverses it.

  1. If you have cavities, you have bacteria in your dentin (the foundation of your teeth) channels. T or F

True also.

  1. These bacteria are the same that are in your mouth at all times, but changed to being able to live without oxygen. T or F

Not fair, that’s in the book and not mentioned in this email

  1. Taking an infected tooth out of a human and culturing the dentin will results in positive bacterial growth, which, when implanted in rabbits, may duplicate the disease the human had. T or F

True

  1. Everyone with a root canal gets better, what’s the big deal? T or F

Maybe true in the short term, but there appears to be a strong correlation with systemic illness occurring when their immune system isn’t as robust as it is right now: after a big life stressor.