Author Archives: Dr John Whitcomb

About Dr John Whitcomb

Dr John Whitcomb is one of Milwaukee's premier functional medicine and Anti-Aging doctors. He is in private practice in Brookfield. He is board certified in Anti-Aging Medicine, Internal Medicine, Emergency Medicine and has a Masters Degree in Nutrition and Metabolic Medicine. He is also now developing Wellness University, an innovative course to teach the fundamentals of nutrition and self care to individuals and companies.

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Chondroitin; The Cure For Heart Disease, Right Before Our Eyes

References:  Exp Med Surg 1969Atherosclerosis 2017,Knowledge of HealthAngiology,

This is strong language. CURE for heart disease. But I think it’s real. What is fascinating to me is that this is not new. It was published in 1969 and disappeared. My eyes were opened when a new client came to me with a story of curing himself, following this method. He had catheterization data to prove it.

So, what’s the deal? It’s really the story of the life work of a cardiologist named Lester Morrison from Loma Linda, California. He was the head of the atherosclerosis research institute there, and dedicated his life to figuring out how to reverse heart disease. And in nut shell, he did. He figured it out and published it.

Here is his logic and his data. He used chondroitin sulfate, which he called the glue of life, because it was the substance that held cells together and appeared to be the first line of defense against the invasion of abnormal fat, or bacteria, or LDLs. He liked it because it appeared to make the arteries more stretchy when the problem was that they were stiff and hardened when they got invaded with LDLs full of fat. He first treated rats, then monkeys with high cholesterol diets and showed that their arteries got typical vascular disease (just like humans), a trouble that he could completely prevent with chondroitin.

He then moved on to humans. This study was published in Angiology in 1973. He had four groups of 60 patients each. First, heart attacks. Of 60 patients on chondroitin who had a heart attack, only 4 died. In 60 heart attacks of folks without chondroitin, 14 died. That’s a big drop. Then, comparing two groups of 60 men with or without chondroitin, he had 10 non-fatal heart attacks in the non-chondroitin group, and ZERO in the chondroitin group. Again, very impressive. The only folks on chondroitin who got in trouble were the four who had fatal heart attacks. The remainder of the chondroitin patients had no heart attacks at all.

Now that was data from the 1960s and 70s. It might have been forgotten had not recent research showed that folks with arthritis taking chondroitin had a 7 fold reduction in coronary events. That sparked interest. Bench research done looking at monocytes and endothelial cells shows that chondroitin dramatically downregulates the inflammatory markers that make all that happen. Those are the cells involved in the first stages of heart disease where lipid pools develop within the artery wall.

Is it registering with you how huge this might be? We can reverse coronary artery disease. Do you realize how significant a hit this will be on our health care industry? Might that be a clue to you about why it hasn’t been widely exposed and talked about before? If you have coronary artery disease, if you have high calcium on your CT scan, if you have angina, claudication, had a TIA, stroke….you should be holding this up to your spouse right now and talking about getting some chondroitin asap. How about you treating yourself. The regimen Dr. Morrison followed can be found in the case studies in the Knowledge of Health Link. Roughly speaking, you need to be on 6-10 grams a day of chondroitin sulfate for a couple of months, then gradually drop down. You might benefit by getting some lab tests to prove to yourself that you are getting better. If you can’t find anyone who will help you, I will. The only fly in the ointment was that this was one doctor, self reporting. A larger, multi-centered trial has not been conducted. Nor will it. This stuff is competing with expensive procedures and drugs. (Forgive me if I have a certain tone of righteous indignation.)

Where is chondroitin from? Most of it is obtained from beef tracheas, which aren’t used for much else. But it’s also the white stuff you see in a chicken’s breast bone and the end of a drum stick.

WWW.What will work for me. This changes my approach to heart disease. I’m chasing down source of good chondroitin sulfate and I will be using it in all my clients going forward. You should be thinking about what and when you will take too. And just because I’m a bit anxious about why this hasn’t been known and loudly recommended for the last 4 decades, doesn’t mean it isn’t true. I’m all in. Now, I have a habit of chewing the white cartilage off the ends of chicken bones. Guess what it contains……? You got it. It is a rich source of chondroitin.

Pop Quiz:

  1. Chondroitin Sulfate has been widely used for arthritis for the last 40 years. T or F

True

It has been shown that folks taking chondroitin for their achy joints has a 7 fold reduction in coronary artery disease. T or F Now isn’t that interesting!

Lester Morrison was a heart researcher in the 1950s-70s who showed that chondroitin had a very dramatic reduction in risk from heart attack death. T or F

That’s the key nugget

Dr Morrison showed that animals with experimental atherosclerosis had dramatic reductions in artery damage when they were treated with chondroitin. T or F

Exactly. That’s what justified his human work

You can get chondroitin from what fat food source?

KFC – chew the white stuff off the ends of the drumstick – it’s a rich source of chondroitin. Too bad it came with all sorts of other less beneficial stuff.

Magnesium: Supermineral for Bones

Magnesium: Super-mineral for Bones

References: European Jr Epid April 2017,

When you get to be 65, as a women, your highest risk of premature disability and death comes from a broken bone. Higher than heart disease and cancer. Tell me about it. Much the same for me as a male. At age 65.5, I have fallen and broken my calcaneus (heel bone) and five months later, am still limping around. We don’t die from all of our fractures, but hip fractures result in a huge mortality. About one in 8 women will have a fractured hip and as many as 30% of them will never return home once it happens. Again, I carry a personal grudge against fractured hips having lost my mother-in-law to that event. Her mail was still on the dining room table when she died, four months later. 
Hence, my intense interest in this research. Magnesium isn’t something we talk about much in traditional medicine. It’s hard to measure. Your bones contain about 50% of your bodies total magnesium supply, albeit it is only 1% of your bone’s content. Your serum magnesium only represents 1% of your total body reservoir, so that is just a tiny sample. By the time your serum magnesium is low, you have a massive deficit, and to get that deficit, your bones have to be awfully deprived. 
The core physiology of what happens with lower magnesium is that the crystals of calcium in your bone get larger and more brittle. Brittle isn’t good. Taking calcium won’t help. Nor will vitamin D help. There appears to be a spooky relationship between Vitamin D deficiency and magnesium. Your low Vitamin D status may be tied up with low magnesium. 
Through most of human history, where did we get our magnesium from? Green plants. Raw. When we cook plants, their cells break down and all the internal magnesium leaks out. When we eat bread and grains instead of vegetables, our magnesium intake drops. When we add animal and sugar, our magnesium drops further. When we deplete our soils with intensive industrial farming, forcing our plants to grow with large doses of fertilizer, our soil magnesium drops, and our food intake of magnesium drops further still. And when we measure our serum magnesium, we really don’t see the deficit until the cow is out of the barn and in the neighbors pasture. 
The study was fairly robust. It looked at 2,245 middle aged Finnish men and followed them for 20 years. They found that those with the lowest magnesium had 44% more hip fractures. Only 22 men had a serum magnesium about 2.3. None of them had a fracture. Notice, only 1% of the men had that blood level. And you should come back to me and say, “Serum doesn’t catch it until way too late.” 
I measure Red Cell Magnesium and rarely, ever, find someone over 6.0. Most of us are in the four range.  There are studies showing that magnesium supplementation helps prevent cognitive decline. And red cell magnesium of 5.5 and above is often the minimum recommended. I aim for 6. To date, of several hundred folks tested, I have only seen 2 who have come to me with a magnesium level of 6. Both were taking daily supplements of magnesium. 
What’s my conclusion? Over 95% of us are functionally low on magnesium. The very best way to get it is with a diet of abundant green vegetables. Or just buck it up and take a supplement. Magnesium threonate is the most recent popular model for brain health. Without good bones, your brains can’t get you anywhere.

WWW.What will work for me. I’m taking magnesium threonate every day. My red cell level was only 4.9 when I tested. Second test pending still. Your should know your red cell magnesium. Aim for 6. Eat more spinach.

Have a Sauna, Live Longer

Have a Sauna, Live Longer

References:  JAMA Internal MedDrSinatra,  TimeWikipediaToxic-Mold-SyndromeTownsend Letter,

Saunas make you live longer. Plain and simple. And where in the world do people take saunas? Finland! Lots of saunas. In fact in this current study, 2,315 men in Finland, ages 42-69, were queried as to their sauna habits and only 12 indicated that they never took a sauna. Just about every apartment building in Finland has a sauna built into its structure, just next to the shower and bathroom.

I first came across Finnish sauna when I visited Finland last year to meet my future daughter in law’s family. They live in southern Finland in the city of Salo, home to one of Nokia phone’s main manufacturing hubs 20 years ago. There, in their apartment, was a sauna. We then went on a drive to see their summer home, and in a lovely lakeside cabin, three more saunas, one indoors and two separate wood fired saunas in their own buildings. My take away message, saunas are common in Finland!

Why do you live longer when you take a sauna? Just in terms of cardiovascular deaths, the reductions were quite extraordinary. For those who took 1 sauna a week, 10% died over 22 years of follow up. If they took 2-3 saunas a week, 7.8 % had sudden cardiac death. Of those who took 4-7 a week, only 5% had sudden cardiac death. For all cause mortality, it was 295 (49.1%), 572 (37.8%), and 62 (30.8%). If you understand hazard ratio (the relationship of intervention to control), the benefit of 2-3 sauna a week over 1 a week was 22% better survival and 63% better survival for 4-7 a week. These are unbelievable numbers. Finally, compared to under 11 minute saunas, 11-19 minutes saunas added an extra 7 % benefit, and more than 19 minutes had an additional 52% reduction in mortality risk. So, longer and more frequent were both better.

What specifically does a sauna do? They may do many things, but one thing we do know is that you sweat. Ok. That’s obvious. Why is sweating good for you? You get rid of toxins. In fact, measurements of mycotoxins in urine show you increase excretion of mold (mycotoxins) toxins 6 fold when you do a 20 minute infrared sauna. Pretty good, huh! Considering that many of us can be shown to have some 287 different toxins in us, thanks to research from the Environmental Working Group, most of us are living with a large toxin burden, stuck in our fat tissue. Saunas may be the best way to get rid of it. Do we know that for sure? Well, not sure sure. But we do know you get rid of a lot of gunk with infrared saunas. And that may be the key.

WWW. What will work for me. This data is so powerful, I’m seriously contemplating getting an infrared sauna. If I can clean up my basement enough to get space, this might be one of the best things we can do for ourselves. Having seen saunas in Finland, I now know that this research is very real, and has real implications. The survival data from this research is just about the most powerful intervention we can do for our personal health. Hmm. You can buy or build your own infrared sauna for under $ 1,000.

Pop Quiz

1. You have to get hot to get a benefit from a sauna. T or F Probably true. Sweating is a key feature. But an infrared sauna isn’t as hot as the traditional dry wood fired sauna.
2. More saunas are better than fewer? T or F True. The benefit keeps climbing up to one a day.
3. You only need to get in there for 5 minutes to benefit? T or F Well, we don’t know. Under 9 minutes had a benefit. Under 5 we don’t know. And more benefit with increments up to 30. So, longer is better.
4. It’s too expensive to get a sauna. T or F Well, if it’s true for you, I’m sorry. But you can do it for about $ 1000 if you do most of it yourself, or even less.
5. And just what is it that happens in a sauna.? A: Measurable dramatic reductions in sudden cardiac death, cardiac events, overall mortality with increasing benefit by frequency and length of sauna. 30 minutes 7 days a week is best.

 

Asparagus, Cure for Cancer

Asparagus, Cure for Cancer?

References:  Hope for CancerAICRSnopes,

Does asparagus cure cancer? Any cancer? No. And it might make leukemia worse. I’ve been asked twice this week about it, so it must be a hot topic out there in email-land. Repeat, it doesn’t cure cancer. By itself.

Is there a nugget of truth in it? Now that’s a whole other story. Yes! There is a nugget. There are several and this is important for you to know.

Nugget number one. Asparagus is a strongly alkaline vegetable. That means it has lots of magnesium and potassium in it, making for an alkaline effect. In simplest summary, if you ate only asparagus, your urine pH would be alkaline. Cancer cells don’t like alkali. They depend on lower acidic pH to facilitate blood vessel growth. More on this later.

Nugget number two. Asparagus has a very low glycemic index. That means it has virtually no effect on insulin. Considering that insulin is one of cancer’s most potent growth factors, the lower your insulin, the less intrinsic stimulation you will get. You are much better off eating all your calories in the form of asparagus rather than cookies and ice cream.

Nugget number three. Fiber. Asparagus has tons of fiber. Fiber pushes the calories down to your colon and nourishes all the biome in your colon. That’s good. Healthy gut biome means robust immune system. We like robust immune system.

Nugget number four. Glutathione. Asparagus is one of our best food sources of glutathione. Glutathione helps you rid yourself of all the negative ions that cancer seems to spew out, which help cancer growth. We like glutathione.

So, what’s the full story about alkalinity? Would asparagus apply and work if you only ate vegetables? The integrative cancer fellowship I took has alkalinity as one of its foundational principles, along with eating low insulin inducing foods. A first step in many cancer programs is to eat more vegetables with high “alkaline” qualities – mostly above ground green leafy type vegetables. Or, take two teaspoons of potassium bicarb a day. Measure your urine pH. You have enough vegetables when your pH gets to 7.0 on first morning void.

Mark Rosenberg, head of the University of South Florida Integrative Cancer Fellowship program, uses alkaline therapy strategies with dramatic effect. By combining the vulnerabilities of cancer cells to insulin, alkali, glucose and oxygen, he has demonstrated quite remarkable cancer burden reduction, and in some cases complete remission of Hospice care patients. His strategies will soon become standards of care. In his hospital in Columbia, South America, he combines heat therapy with high dose glucose and oxygen to ramp up cancer metabolism, then blocks acid excretion from cancer cells, forcing the cancer cell to become internally acidotic, and die. No side effects. No human toxicity. Cancer shrinks.

Alkaline therapy works, in the case of making it extreme, like Dr Rosenberg. It should be slightly effective in the single serving of asparagus. Will you be able to demonstrate a cure. No.

WWW.What will work for me. Many of these alleged cancer cures have a tiny nugget of truth. The devil is in the details. I eat asparagus with enthusiasm. But I also eat the widest variety of vegetables I can get, as long as they aren’t root veggies. The roots have too many carbs.

Pop Quiz

  1. You can cure cancer with asparagus? T or F                If you can find a real case, please call me. Until then, it’s false.
  2. Asparagus has some cancer fighting qualities? T or F                  True: here you can say true. To get to a cure, you might need to eat more than humanly possible.
  3. Alkaline therapy, which includes asparagus and other green vegetables, may have a dramatic impact on cancer.            T or F                          Now you are cooking. True. Maybe not yet fully appreciated.
  4. You will get less cancer if you weigh less. T or F                        This is generally true. Your insulin level is lower when your fat cells are smaller. Insulin is a growth factor for cancer cells.
  5. You can fight cancer by eating fat and less carbs. T or F                      This is also true, but it’s a whole other topic. Cancers can’t digest or metabolize fat. Simply that

 

 

 

 

 

 

 

 

VIP: Very Important Peptide

VIP: Very Important Peptide

References:  WikipediaBiotoxin Journey,

Actually it’s VASOACTIVE INTESTINAL PEPTIDE. That’s where it was discovered, in the gut. Though it was found in the gut and pancreas, it is also made, in abundance, in the hypothalamus. It has a huge library of effects from extra heart contractility to relaxation of capillaries to gut motility, gallbladder and trachea muscle relaxation, increasing water and electrolyte secretion into the gut. All of its effects on the gut are to increase its activity and movement. It also helps prolactin secretion, leading to breast feeding. It’s critical to the daily clock function in your brain. It helps women’s vaginas lubricate. It has a very potent effect on heart pumping and peripheral vascular relaxation. This is a huge portfolio of activity.

Did you know that it does one final good deed? Folks who have mold illness CIRS (Chronic Inflammatory Response Syndrome) who hurt all over, can’t sleep, can’t lose weight, have no energy and just plain feel miserable, will often have very low VIP levels, which, when replaced, can lead to almost immediate relief. Can you imagine that? Imagine a chronic fatigue patient who has been given pain pills for years, can’t hardly get out of bed, is way overweight and eats like a bird who rises out of their stuporous state to normalcy when they get VIP given to them.
Too good to be true? Well, possibly. For that sort of effect to happen, Shoemaker from SurvivingMold.com has given it to several thousand patients and found it to be the last step of his 11 step program, where it works with great results, if all the prior 10 steps have been followed. He contends that treating with VIP before you have taken the first 10 steps is somewhat akin to painting a burning house. You have to put out the fire first.
Just how is all that happening? CIRS happens in only 25% of the population. 75% of us can get away with being exposed chronically and not get sick to mold toxin. But of that 25%, 2% are wickedly prone to devastating illness. Ironically, their illness is all at the level of cytokines and brain peptides, with typical lab all looking normal. CIRS (Chronic Inflammatory Response Syndrome) only shows a few clues around the edges, like high CRP, of normally done lab tests. Routine doctors visits end up with, “You look great” and no answer to devastating fatigue, systemic aches, horrible sleep, lousy brain fog, no good memory and inability to exercise.
How do you put out the fire? Shoemaker’s 11 step list is pretty detailed.
1) You must remove ongoing sources of exposure. That’s absolute or everything else is a waste of time 2) Then reduce the body burden of toxin by binding it in the gut and getting it out by the use of cholestyramine 3) Clean up the nose where you likely have MRCoNS (methicillin coag-negative staph), 4) fix MSH, 5) fix MMP-9, 6) fix ADH/osmolality, 7) fix VEGF, 8) fix C4a, 8) fix TGF beta-1, 9) fix CD4+CD25+, 10) Finally, if VIP is low and symptoms still persist, replace it. That’s when the miracle occurs. Steps 4-9 all have clear methodologies to measure and repair their attendant problems. The treatment with VIP needs to be done with great care, following a careful protocol of treatment, monitoring and followup. It is possible to get pancreatitis from using it, so its use is not without risks.
Does this relate to you? It may not. But there folks who are just crippled with symptoms and nowhere else to turn. If you know one, forward this to them!

WWW.What will work for me. I’m deep into my mold certification. I’ve got the lab lined up and the first folks getting tested. There are more than just a few folks for whom this story rings true. Let’s see if we can bring them relief!

 

Pop Quiz

  1. CIRS stands for…?

A: Chronic Inflammatory Response Syndrome

Standard Lab tests show what in CIRS? A: Nothing. Maybe a high CRP

  1. VIP is a hormone with fantastic ability to improve fatigue, sleep, pain, brain fog, chronic pain, joint aches…. T or F

A: True, if the person has CIRS and has taken all prior 10 steps of the Shoemaker Protocol

  1. VIP is a widely active hormone: Name two of its actions.

A: Makes heart beat stronger, blood vessels relax, gut make more juice, gallbladder relax, vagina lubricate, brain calculate time….(probably more to come)

  1. VIP is very safe to use and has no side effects. T or F

Not true at all. It can cause pancreatic and requires careful lab and physician monitoring.

ProOpioMelanocortin

POMC: The God Protein

References: Wikipedia, Uniprot,

Proopiomelanocortin. Repeat after me. Proopiomelanocortin. Bet you never heard of that before. What is it? It’s the protein that runs you. It’s a large protein that is in your pituitary gland that is made from pre-pro-proopiomelanocortin, a 285 amino acid long peptide that is activated once the 44 amino acid activating fragment is removed. Then it is ready for activation. It’s all in its name, at least part of it. Opio – it has opioid activity in part of it. Melano – it has melatonin activity. Cortin – it has cortisol activity. The devil is in the details. It is the prototype-hormone that can be split in many directions, depending on what enzymes attack it and chop it up into other pieces. It is those other pieces that become the hormones that run your body. ACTH heads off to the adrenal glands, giving you cortisol for energy and stress response. MSH has all sorts of appetite and sexual activity implications. The appetite part works through leptin. Generally it suppresses appetite as does leptin, when you aren’t leptin resistant. Beta-endorphin manages pain perception and immune function.

The devil is in the details. POMC can be chopped up into at least 10 different hormones, depending on where it is chopped. All the regions are overlapping with each other so any one hormone that is created might nix the making of another. It all depends on which chopping enzyme gets activated, and the activation is managed by adding or subtracting marking sugars or acids attached on certain sites.

An example of how it works goes as follows. You go to the gym and exercise like crazy. Imagine a good Cross Fit workout, or a great tennis match, or a hard 5mile run. Your body is demanding more fuel so you put out the call for more cortisol to mobilize more fuel. To make more cortisol, you need ACTH. First you chop the pre-pro-proopiomelanocortin into proopiomelanocortin. From that you then chop it into ACTH. When you make ACTH, you also, by chance make beta-endorphin. That’s your natural opioid. Presto: you feel a warm glow of happy feelings. The runner’s high.

That’s what happens when it works well. Guess what happens when it gets screwed up? The CIRS (Chronic Inflammatory Response Syndrome) as typified by black mold attacks you right at POMC. By downregulating the natural ebb and flow of POMC, you block beta-endorphin, ACTH and leptin which results in your being utterly unable to lose weight, not sleeping well, hurting all over and having no energy. Sound like anyone you know? We shy away from all those folks because it is to awfully overwhelming. We call people with that “Chronic Fatigue” or “Fibromyalgia” and give them pain pills and usher them out as fast as possible.

It might be kinder to investigate why they are feeling so awful. Ritchie Shoemaker, the author of the web site www.survivingmold.com claims that 80% of folks with chronic fatigue actually have CIRS, and positive markers for mold. They represent as many as 25% of the population when you do genetic testing for those who are susceptible to mold toxins. All they need is repeated exposure. 2% of folks are exquisitely sensitive, and 5 minutes in a sick water damaged building will set them off. If you can fix their POMC and get it back to normal function, their suffering will be over and they will claim you were the dispenser of a real miracle: the God Protein.

WWW.what will work for me. I’m totally fascinated with POMC and have started working on being certified as a Black Mold specialist. It’s a couple hundred articles and pages of reading, but if I come out being able to fix those folks who have been blown off by 8 other physicians and given nothing but symptom relief, I’ll be pleased. I am getting awfully hyper about any water leaks in my house. There are roofers up on our roof right now making sure our house stays dry. Mold will happen anytime you let water leak in your house, and don’t fix it promptly.

Pop Quiz

‪1. POMC is the prohormone that modulates your sex drive. T or F

Well, part of it does. There are implications for sexual function in MSH but more of it’s components go to energy and pain control

‪2. POMC can be chopped up to make how many hormones?

A: At least 10 and maybe more

‪3. Can they all be made at the same time?

No, any given combination will only make 2 or 3 depending on where you cleave the protein. This means there is lots of overlap.

‪4. The toxins of mold do their dirty deed by disrupting POMC. T or F

A: Bingo

‪5. Mold illness is rare. T or F

Are you kidding? Probably as many as 25% of our population has the genetic tendency to be affected. Likely only 2% are exquisitely sensitized, but that is still a huge number. (6-7 million exquisitely sensitive, 90 million partially sensitive.)

IV Vitamin C Stops Sepsis Cold

IV Vitamin C Stops Sepsis in Its Tracks

Reference: NPR, Chest, Managed Care, Barry Fowler, Biofactors,

The number three cause of death in America today is the overwhelming infection that causes blood pressure collapse, kidney shut down and death called sepsis. Three hundred thousand people in America die from it each year. As far is deaths in hospitals, it’s number one. Sepsis is dangerous.

The cause of sepsis is still not exactly known, but it acts like a runaway train. “Cytokine storm” is the term used to describe the same process in severe influenza, where all your hormones of inflammation fire off in a cycle of uncontrolled and dysfunctional activation. One thing in known, there is a leaking of capillaries all over the body while alarmins (danger-associated molecular patterns (DAMPs)) are released. These DAMPs are nuclear, cytoplasmic, or mitochondria structures that acquire new functions outside the cell. Examples of DAMPs have great names like high mobility group box-1 protein HMGB1, S100 proteins, and mitochondrial DNA. And as a result of all that, you get organs shutting down one by one. Kidneys you can dialyze, lungs you can breathe for but once you hit three organ systems, you are done.

So, imagine the surprise when Intensivist Paul Marik from Norfolk, Virginia reported on 47 cases of sepsis in which only four died, but not one not from their sepsis. He compared that to 47 prior patients he had treated, 19 had died from the sepsis. What was the difference? IV Vitamin C. Dr Marik reports on his first case and decided to try the idea of IV vitamin C because he had heard promising case reports from Barry Fowler, and figured nothing else worked. His first patient already had her kidneys and lungs failing when he got to her and he fully expected her to die the first night in the ICU. Instead, after the IV Vitamin C, he came back in the morning to find her smiling, looking well and ready to get out of the ICU. He is now treating all his sepsis patients with IV vitamin C and some extra steroid and thiamine. He has now reached 150 patients with only one death from sepsis, far short of 30%.

Just what does IV Vitamin C do? We now know that something about sepsis depletes Vitamin C, and that depletion may be the tipping point in the accelerating vortex. When you take Vitamin C by mouth, you get a normal level of 3 all the way up to 6. That’s not much. When you take it by IV, you can get to a level of 3-500, depending how much you take. And that in 5 minutes after you stop the infusion. Complications from IV Vitamin C. Zero.

WWW.what will work for me. I’ve seen it myself. I’ve seen IV vitamin C heal severe pain from shingles. I’ve seen it fix cold and flu. And I’ve had dear close friends die from sepsis. This idea needs to get into our local hospitals so that you are protected if you get this wicked, spiraling, lethal vortex of cellular collapse. If you know an ICU doctor who would be amenable to training, have them call my office. I’ll teach them how to do it. One of my faculty had ecamplsia with twins. She was in shock and nothing was working. She chattered through shaking teeth: “Get me some IV C”. They did, and her eclampsia cooled off in under an hour. That’s just an anecdote, but that’s where progress starts.

Pop Quiz

‪1. The number one cause of death in hospitals is? Heart Attach, Cancer, Stroke, Sepsis.

Answer: Sepsis. Remember, I said, “In hospital”. Lots of heart attacks happen at home, on the way, in the nursing home, at sleep…..

‪2. We have about 70% chance of dying when we get sepsis? T or F

A: False. It’s about 30% but of a million cases in the USA every year, that’s a lot.

‪3. A cocktail of IV Vitamin C, steroid, thiamine reduced mortality to 1-2%. T or F

‪A.  One doctor study can’t really be quoted as evidence, but it sure catches your attention.

‪4. You are protected at hospitals in Milwaukee from death by sepsis. T or F

False

‪5. Infusion of IV Vitamin C is dangerous and must be supervised by a doctor. T or F.

Emphatically false unless you are really sloppy and let the IV infiltrate or don’t wash your hands or some other really stupid thing. I’ve done several thousand and have yet to see anything dangerous.

Eat to Optimize Your Connexins

Eat to Optimize Your Connexins

Reference: Holistic Primary Care, Remer and Mainz Jr Aced Nutr Diet, PRAL, Gap Junctions; Cold Spring Harbor,

We defined connexins two weeks ago as the links between cells that allow them to communicate rapidly and fluidly back and forth, leading to organs acting in similar coordinated fashion. Connexins allow multicellular organisms to exist, because individual organs can carry our separate functions. Liver cells act like liver cells, and blood vessel cells act like blood vessel cells, in part because they are connected to the cells next to them by connexins. Last week, we identified that many if not most diseases show reduction in connexin behavior and number. In particular, adult diabetes shows reduction in the ability to secrete insulin. There is evidence for many diseases that connexin disfunction is at the heart of the disease.

Now, can we change our connexins by lifestyle changes? To which the answer is an emphatic YES! What you eat, how you exercise and how you handle stress all have implications for connexins. That means the nature of the food we eat can get to the heart of healthy actions.

What is that nature? What makes the difference? Acid and alkali. What you eat has net acid or alkaline implications. Darrell Tanelian, MD’s book, Molecular Fitness details the implications. When you eat any food, your body digests it and the biological ash left over after you have used the food for what you use it for, is either acid or base. As a general rule, vegetables and fruits have magnesium and potassium salts which make for alkali. Meat and cheese makes for acid. You can see the sum of what you ate in the pH of your urine. As a general rule, Americans eat a lot of meat and cheese, and our urine is pH 5.5, slightly acid. Vegans tend to have less acid in their diet, and have more alkaline urine. Chimpanzees, gorillas, and monkeys are mostly vegetarian, and have quite alkaline urine.

As the acid passes through your body, your don’t change your pH in your blood. At least, not very much. Instead, you breathe differently and change the balance of pH buffers in your blood. Your serum pH doesn’t change but for a tiny bit, but your buffers change a lot as you balance out the acid passing through. And that has a huge impact on connexins. At a healthy pH of 7.4, the connexons, (the name for the link made by six connexin proteins assembled into a coating tube) are wide open. At a pH of 6.9, they are shut and cells aren’t talking to each other. Your body is shutting down. An example of that would be when you run and leg shin splints. Your muscles won’t work because you built up too much lactic acid in your leg muscles. At the molecular level, you have connexons failing. Now, in normal living your pH never ever goes below 7.3 from 7.365, but the trend line is there.

The implications of this are significant. In the long run, optimal health is going to come from a diet of abundant vegetables and fruits that makes you alkaline. Raisins, for example, are premier alkalizing foods. All vegetables have magnesium and potassium salts that participate in “alkalizing” you. That keeps your connexin proteins making open, functioning connexons.

What to do with a ketogenic diet that is higher acid? Losing weight and reducing blood glucose is so critically important that the cost benefit is clearly on the side of losing weight. Once your weight is lost, the more vegetables you eat, the better. Fat is pH neutral, so butter, coconut oil and olive oil are dandy.

www.What Will Work for me. I have diabetic genes, as do most of us. I’m finding lots of recipes that are rich in fat and vegetables. We went to an Indian restaurant this weekend and I had okra curry. Delicious. Hold the rice. I managed to make it through dinner and not mention connexins once to my table mates.

Pop Quiz

‪1. Connexins are the proteins that assemble together to make connexons, the communicating links between cells of similar types. T or F

True. Whew, you get it right, after three weeks.

‪2. Connexin proteins are necessary for animals to have multicellular structure that works in a coordinated fashion. T or F

True

‪3. We haven’t been able to identify changes in connexons with diseases making them an interesting oddity, but not clinically useful. T or F

Pants on fire, false. We don’t don’t know how to test them, but their are dramatically altered in just about every illness of any organ system.

‪4. We don’t know how to alter connexin function? T or F

Pants on fire again. Many supposedly “healthy” behaviors also have beneficial impacts on connexins. Exercise, stress reduction, good sleep, healthy eating all have beneficial impacts on connexins.

‪5. The most significant thing we can do improve connexin function is to eat what?

Answer: More alkalizing foods; rich in potassium and magnesium – fruits and vegetables.

Connexins and Diabetes

Connexins and Diabetes

References: J. Cell Biology, J Biol Chemistry, FEBS Letter,

Connexins. What we learned last week was basic. Connexins are the proteins that make for connections between cells. They exist in every creature with more than a few cells. For multicellular organisms to exist, connexins have to become part of the picture. And the management of fuel for cells in central to an organism that has specialized digestive processes. To have a gut, blood, central nervous system, bones, muscles and everything else means you have to have a centralized control system for fuel allocation. That central traffic cop is the pancreas gland with its beta cells. They produce insulin, and insulin is the key hormone used to signal storage of calories for future use. Traditional medicine calls insulin your blood sugar controlling hormone. A more inclusive vision would be to say that insulin rises in response to rising blood sugars which occurs during the time of year of calorie excess, just before the time of year of calorie deficit. It’s a good time to store calories.

The storing of calories as insurance against future starvation is a key feature of human survival (and all creatures). That’s insulin’s job. How do connexins play a part in all that? These articles this month go right to the heart of that role. When you knock out the ability of pancreas beta cells to make connexins, their ability to make insulin drops proportionately. This means for us to have a sensible, balanced and nuanced control of glucose, we have to have proper connexin function.

What happens in humans when we get overweight, and become diabetic? Our fat cells get bigger and we demand more and more insulin to keep glucose in a tight range. We can produce that extra insulin for a while, but eventually exhaust our ability to produce sufficient insulin to control blood glucose adequately enough. Glucose is a very reactive chemical. Granted, it is fuel to burn, which is why being reactive helps, but high levels of it stick to all sorts of places where it’s not meant to be. And that leads to disease too. Our body doesn’t like high glucose, and we frantically put out more insulin to regulate that. And what happens when we can’t make enough insulin any more? You got it, the first step is connexons between cells dropping off as we produce fewer and fewer connexins. This makes connexin dysfunction the first step in diabetes development. The ability of our beta cells in our pancreas to talk to each other via their connecting connexins is the first step to developing diabetes.

And guess what happens in heart disease, brain disease, muscle disease, kidney disease?…..Name an organ and I can show you references that demonstrate that connexins fall off and connexons (the name for the actual channel between cells) between cells decrease. The level to which all your organ types are connected to each other is the level to which you are healthy. This loss of intracellular connections via these proteins called connexins is the basis of much illness.

The $ 64 k question is, what can we do to alter our connexins? Is that something we have control over? And the answer is yes! Next week.

www.What will work for me. All right. I’ve learned that connexins are the protein channels between cells that allow communications between similar cell types, allowing different cells to act as coordinated organs. Muscles can contract together. Liver cells and digest together. Brains can think… etc. Sounds like this is at the heart of life of multicellular organs. I love getting down to the very basic facts. But I’m eager to know how I can alter it with my own behavior. I guess for that, I have to wait till next week.

 

Pop Quiz:

‪1. Connexins are the key mechanisms of different cell type to function as independent organs. T or F

Right on.

‪2. In diabetes, our pancreas beta cells have more connexins functioning with higher blood glucose. T or F

False.     That’s backwards.

‪3. Virtually every illness with organ dysfunction can demonstrate lousy connexins of the organ that’s not working. T or F

T.  Isn’t that fascinating?

‪4. Earth worms have connexins. T or F

True. They have muscles that work in a coordinated fashion. That wouldn’t happen without those links.

‪5. Our gut has connexins that get discombobulated with gluten. T or F

Bingo. You intuited that and you were right. Gluten disrupts connexins between gut cells.

 

Connexion Connection

Connexin Connection

References: Wikipedia, Molecular Fitness,Cell Science,

Ever heard of Connexins? I hadn’t. Until I read Darrell Tanelian’s book. Here is what they are. They are the proteins that make up the connecting channels between cells. Different organs in your body act together in concert because they know they are the same as their neighbor. A liver cell knows it is a liver cell because it has hundreds of connecting little passageways between itself and it’s neighbor. Those protein bridges are constructed of 6 identical proteins that fit together to make a cohesive channel that connects one cell to another. A brain cell knows it is a brain cell because it’s connections tell it that it is in a brain environment. Same with pancreas, gut, muscle, heart, kidney, bone…..you get the drift.

That channel can relax and open up, letting stuff through, or it can shut down and close off passage of any signaling messages. A healthy cell has a lot of connecting passages/links between itself and its neighbors. And an unhealthy cell has less and less connecting sites.

You will get the drift of the power of connexins with gut cells. Your intestine has a one cell layer between your food (the outside world) and your inner self, your immune system and blood supply. That cell layer is held together with three tiny bridges of connexins. Inflammatory bowel disease appears to be an illness of uncontrolled inflammation, in part because of dysfunctional connexin activity. This appears to be the cutting edge of gut research right now, as the functions of connexins, and their cousins, panexins, appears to be the mechanism behind most gut diseases. There are even some commercial companies selling the agents that pass back and forth between gut cells in their communications through their gap junctions as a means of fixing gluten and glyphosate injury to the gut.

The bottom line of connexins is that they allow multi-cellular organisms to exist. Without different tissues being able to differentiate themselves into organs with separate form and function, we wouldn’t benefit from being anything more than a big algae. The process of cellular evolution from single cell to human beings is founded on connexins. They had to come very early in the game of life on earth. Being that fundamental to human form, the well being of connexins and understanding their role in health for the greater organism might be a critical link to understanding. And that is about as state of the art as we can get.

WWW.What will work for me. I want to know more. I love getting down to the details, especially it it’s something I can change with lifestyle choices. I found the topic getting a sense that being overweight and insulin intolerant starts with dysfunctional connexins. I’m fascinated. More next week.

Pop Quiz

‪1. Connexins are proteins that allow cells to communicate with each other. T or F Bingo

Right on the money.

‪2. The ability of different tissues to act differently from other tissues depends on cells working together in a coordinated fashion, which requires connexins? T or F

Ok, now you are on a roll.

‪3. If I understand it, connexins might then be part of organ tissues repairing themselves, and keeping them selves happy? T or F

You are getting ahead but you got the drift. We are now researching how to repair damaged heart tissue with stem cells. Their ability to develop into new heart cells requires that they get their connexins right.

‪4. Single cell organisms have connexins. T or F Nope.

It’s connexins that define multi cell organisms, up to and including you.

‪5. Every organ in the human body has connexins. T or F True.

And their health depends on their having a good population of them.

 

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