Leptin Resistance and Inflammation

Leptin Resistance and Inflammation

References: Am Jr Coll CardVitamin HormonesCurr Immunol ReviewCell,

Leptin is the hormone that has several important functions. One is that it is secreted when your fat cells say they are full. It is a feedback loop that tells you that you have had enough to eat, so stop. Fine and dandy. But like everything else in your body, there are layers and layers of delicate complexity far exceeding the first layer of functionality. Another layer is that it essentially mediates the release of fat from fat cells, making it the guardian of your energy stores. When all is well and working properly, your leptin level falls when you don’t have food and your fat cells open up and share their calories. Women have more leptin than men. As a general rule, gaining weight results in a higher leptin level which should result in your feeling full and not eating. Something strange happens, however, when you get inflamed.
The fly in the ointment here is that there is an intersection between metabolism and inflammation. The leptin receptor in your hypothalamus appears to be a critical link. It turns the Proopiomelanocortin system and has you produce melanocortin. MSH. MSH is a potent down-regulator of appetite. With a nice high MSH, you don’t feel like eating. Low MSH, you don’t have a feedback loop. And just what happens with inflammation? Leptin plays a role in that it has a critical effect on innate and adaptive immune response. It promotes the secretion of cytokines like IL-6 and Tumor Necrosis Factor, and there you have it. It sets up the link between metabolism and inflammation. What you see is a dramatic dysregulation of inflammation in folks who become overweight, and thereby establishing the first step in increasing risk for Alzheimer’s, heart disease, cancer, autoimmune disease and just about everything else that ails us. The “Common Soil Hypothesis” is the concept that metabolism and inflammation came from the same source in evolution, way, way back. Here again, we see that nexus and it makes for problems.

What you see happen is as follows. Folks with inflammation, like low-grade mold exposure, have low MSH and high cytokines that damage the leptin receptor in the hypothalamus. Leptin drifts higher in response, trying to bring about control of calorie balance. The person gains weight. Leptin goes higher, but the receptor is damaged and the higher leptin then mediates more inflammation. Around and around you go. If you feel overweight and have chronic pain or chronic fatigue, you likely fit this model. Forget trying to lose weight until you lower your leptin.

How can you lower your leptin most effectively? I suspect the fast mimicking diet will do so, but that is not yet proven. The one good study that shows regeneration of the pancreas beta cell used mice with a genetic defect in their leptin receptor, so they couldn’t be used to proven leptin repair. Right now we can use pioglitizone (ACTOS) which is an old fashioned diabetes drug that has lots of side effects when used for too long, but is dandy at lowering leptin and MMP-9, two mold effects.

Can we reduce leptin with our own lifestyle? Well, quite a lot. If you focus on several key items, you can guide your leptin lower. Keep your daily sleep cycle to a regular pattern. That plays into your POMC system being played every day at the same time. Avoid sugar. Increase fat in your diet. Cut down on your evening meal and increase your daytime eating, making for at least 12 hours of fasting each night. Exercise. Sleep at least 8 hours, starting with at least 3 hours of no food before bed. Consider training yourself to enjoy a cold shower, particularly if you get a nice hot sauna just before. (The Finns had it right.)

WWW.What will work for me. I’m fascinated with leptin and mold illness. I keep seeing women in particular with not only high leptins but super high leptins levels. Just about every one of them has had low MSH levels, meaning some sort of mold or biotoxin exposure. Throw in stress, sugar, lack of exercise, lousy sleep and we make for a perfect storm to elevate leptin, and keep everyone overweight and inflamed.


Pop Quiz.

  1. Leptin helps you make MSH which suppresses your appetite. T or F                Answer: Almost right but backward. LACK of leptin results in hight MSH, and then weight loss and lack of appetite.
  2. Inflammation turns on leptin. T or F                                                                      Answer: I’m into backward today. It makes for leptin resistance, which then elevates leptin.
  3. Name a few means by which you can lower your leptin with lifestyle changes. Answer: Regular schedule, exercise, sleep, 12 hours of fasting, weight loss, less sugar….
  4. Leptin allows the release of MSH. What does MSH do?                                     Answer: It’s a potent appetite down-regulator.
  5. The cause of fibromyalgia is likely?                                                                    Answer…….. /biotoxin illness leading to damaged leptin receptors.