Biotoxin XII: Cleaning up C3a

References: Surviving Mold, Mold Warriors, p 396Jr of Immunology,

Ever heard of C3a? Bet you hadn’t. Ever heard of statins? Sure. That’s where statins work. And C3a is the heart of biotoxin illness. It is the nexus of the complement system. The complement system is the cascade of inflammation that fires off when your body sees and recognizes an outside invader. We have made the analogy of biotoxin setting off the 911 alarm system in your community with sirens blaring everywhere. C3a is the volume of the siren.

You can look at a diagram of the C3a activation system. and you see that the production of C3a is the first summary action. And uniquely, it plays in role in starting the inflammatory process, and then in modulating and reigning it in. Shoemaker has discovered that C3a is like the gift that keeps on giving in mold illness. When folks get sick, it’s C3a and C4a that go up right away. In Lyme disease, C3a is a unique marker for early Lyme and can skyrocket with two days of infected Lyme bite. The same happens with acute mold exposure. C3a rises as soon as within 4 hours of exposure to mold. In folks with the genetic HLA biotype for susceptibility to Lyme, the C3a doesn’t go back to normal with the proper antibiotics. In folks with a normal HLA genotype, their C3a goes back to normal. That explains the Lyme riddle of why some folks never get better with continued antibiotic.

What’s going on in mold with high C3a? The complement system continues to be activated. Low grade inflammation of the innate (lizard) system keeps happening and the involved person keeps feeling ill. What ever organ appears to be affected continues to be affected. For those with plaque developing in their brain, they keep developing plaque. For those getting asthma, they keep getting worse. For those getting coronary artery disease, they keep getting worse. C3a is the attack dog of the innate immune system, and it continues to rot you out from the inside.

Now, along comes a unique cure. Guess what lowers C3a and puts it to bed? Guess what resolves the inflammation and cures C3a, provided the mold exposure is gone? A high dose statin. For a month. Yes. A statin. Imagine, is this why statins work? You can search the internet and see lots of odd links, but Shoemaker has seen the clinical evidence of coronary artery disease and “cholesterol” normalizing with C3a normalizing. Now, you need to start CoQ10 at least a week before you start the statin, and push whatever statin you use to its upper limit, and then watch the C3a fall. And with the MMP9 coming down, and the PAI-1 coming to normal mean the illness was cured.

Can you imagine the scope of biotoxin illness if everyone developing coronary artery disease had their HLA typing and their C3a measured. This topic might have broader implications than anyone has imagined yes.

WWW.What will work for me. Well. Measuring C3a is turning out to be quite a challenge. I haven’t figured it out yet in Milwaukee. None of my labs have done it right, so we are in that stage of trying to navigate this journey. Once we can get the wheels greased for the lab evaluation, I have lots of folks pent up waiting to get better. But they only get better when their mold illness is fixed, and that starts with their homes and their workplaces. I got Sporocidin today and the sprayer is coming. I want my basement to smell pristine when I’m done. Sporocidin is the cleaning agent you want to use if you have a “moldy” smelling basement.


Pop Quiz

1.      C3a is the common instigating cytokine in the innate immune system? T or F                  Answer: That is about as accurate as you can be

2.      C3a both activates and modulates the innate immune response. T or F                           Answer. Again. Just about right.

3.     In acute mold illness, C3a rises very rapidly? T or F                                                                Answer: Bingo, you can prove it with reexposure.

4.      In Lyme Disease with the dreaded Lyme HLA phenotype, you get better in just two weeks. T or F       Answer: This was my dummy question. If you got this wrong, you didn’t read the column and skipped to the pop quiz. False.

5.     And you can cure high C3a, and in fact MUST cure high C3a, with what?                           Answer: High dose statins for a month, after meticulous removal from exposure.


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