glutathione

Biotoxin Illness Part III: The Role of Glutathione

References: Toxins (2014)SciWorldJr,

So, you know about your immune system having two layers, the innate or lizard system, and the adaptive or precise mammalian system. A good analogy is like a bomb going off by a terrorist. Your city reacts with a curfew, 911 is activated, the police clear the streets, sirens are wailing. This is your innate immune system – “all hands on deck, but who is it that we are fighting?”. Nonspecific, system wide, reactive. Then, surveillance cameras pick up a suspicious character and his license plate is put out there with a sketch of what he looks like. Then his picture shows up from the driver’s license bureau. This is slower, your adaptive system, but it has precision and accuracy.

What are you using to clear the toxin, once you know what it is? The answer is glutathione. Glutathione is simply three amino acids tagged together but they have sulfur atoms in them, making it able to soak up loose electrons. Every cell in your body has it. It’s your natural defense, in effect, part of your 911 mop up system. It’s sort of like your fire hose cooling off the burning embers of the fire. And as you age you make less of it. Dramatically less.

Turns out, it is a critical player in Biotoxin illness. It enables your body to tag and dispose of mold toxins. The paper we review this week details how we make glutathione through a delicate dance with Nrf signaling and the protein GST or Glutathione S transferase (GsT) . There are 7 GsT types inside a cell, and the first and most common has many genetic variants. Half the adult population has a polymorphism that is dramatically less active. This has been associated with oxidative stress all over the body, most notably in the brain with Alzheimer’s. Mold toxins wreak some of their havoc by down regulating the level of glutathione production. And as we age, our levels of glutathione drop dramatically.

Well, well! If that’s what mold toxins do, what would happen if we gave glutathione to someone with all the symptoms of biotoxin illness, and positive markers of biotoxin disease? Here are two stories. A middle aged woman with three years of asthma symptoms not responsive to typical asthma therapy and cleared of asthma by the traditional medical system becomes symptomatic again. Treatment with one gram of IV glutathione for three days completely reverses her symptoms. In fact, her oxygen saturation surged from 95% to 98% within 10 minutes of treatment.
A second story. Multiple insect stings. A mid seventies women with over 15 hornet stings, treated with traditional Benadryl with only partial success. Insect stings are known to be another entry into the Biotoxin pathway. Two treatments with 1 gram IV glutathione result in dramatic and almost immediate, complete recovery.

Did you get that? Now, you can’t take oral glutathione easily as it is digested in your stomach like any other protein. And not everyone has access to IV glutathione. (It is just 3 amino acids long). But you can take it in “liposomal form” which is widely available in Supplement stores and on the net. And, more importantly, you can take N-acetyl cysteine or NAC and give yourself the rate limiting cysteine combination. NAC is a revolutionary supplement that has been around for 40 years. 40 years ago it revolutionized Tylenol overdoses. Prior to NAC, a Tylenol overdose was a guaranteed death sentence or liver transplant. NAC is so powerful that folks with Tylenol overdoses are now sent home from the hospital with NAC to take a couple of times a day. No wonder NAC makes Bredesen’s supplement list for Alzheimer’s prevention.

WWW.What will work for me. Well, I take NAC in my daily supplement list. If I was still an emergency physician, I would find a way to study glutathione for folks with nasty insect stings. But I’m now adding IV glutathione to my treatment regimen for everyone with Biotoxin illness. The jury is out about randomized, placebo controlled trials. But considering that glutathione is in you already, just less because you are old, means you and I should consider paying attention to our glutathione levels as we age.

Pop Quiz

  1. Glutathione is my natural antibody booster. T or F                                          Answer: False. Nothing to do with antibodies as that is the adaptive, more precise immune system. So called “glut” is your innate immune system’s fire hose. Just calming things down.
  2. As we age we make more glutathione. T or F                                                    Answer: Again, false. Testing to see if you actually red the article. Much, much less.
  3. Biotoxin illness down regulates your production of glutathione. T or F       Answer. Ok, we will give you a true
  4. There is a simple supplement that gives you the amino acid pieces to make your own glutathione. And it is called……………..                                                                 Answer: NAC or N-acetyl cysteine
  5. We all make pretty much the same amount of glutathione. T or F                 Answer: surprisingly false. There are 7 different forms of glutathione converting enzyme inside the human cell, and the first and most dominant one comes in form that is much less active in 50% of us. Why, we don’t know. But every protein has many slight alterations that we inherit in our gene mix called polymorphisms. That happens to be one that is curiously dysfunctional.

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